quinolinic acid

简明释义

喹啉酸

英英释义

例句

1.Increased production of quinolinic acid has been linked to inflammation in the brain.

增加的喹啉酸产生与大脑中的炎症有关。

2.The study suggested that quinolinic acid might play a role in the pathophysiology of schizophrenia.

该研究建议喹啉酸可能在精神分裂症的病理生理中发挥作用。

3.Therapeutic strategies targeting quinolinic acid metabolism may help alleviate symptoms of depression.

针对喹啉酸代谢的治疗策略可能有助于缓解抑郁症状。

4.Researchers found elevated levels of quinolinic acid in the cerebrospinal fluid of patients with neurodegenerative diseases.

研究人员发现神经退行性疾病患者的脑脊液中存在升高的喹啉酸水平。

5.The enzyme responsible for producing quinolinic acid is often overexpressed in certain cancers.

负责生成喹啉酸的酶在某些癌症中通常过度表达。

作文

Quinolinic acid, a metabolite of the amino acid tryptophan, has garnered significant attention in recent years due to its complex role in various biological processes. As a product of the kynurenine pathway, quinolinic acid is synthesized in the body and is involved in several neurological functions. It is known for its neurotoxic properties, which can contribute to the progression of neurodegenerative diseases such as Alzheimer’s and Huntington’s. Understanding quinolinic acid is crucial for researchers aiming to develop therapeutic strategies against these debilitating conditions.The biosynthesis of quinolinic acid begins with tryptophan, which is converted into kynurenine through the action of the enzyme indoleamine 2,3-dioxygenase (IDO). This process is tightly regulated and can be influenced by various factors, including inflammation and stress. Once kynurenine is formed, it can be further metabolized into several other compounds, including quinolinic acid. The accumulation of quinolinic acid in the brain has been linked to excitotoxicity, a process where excessive stimulation of neurons leads to cell damage and death.Research has indicated that elevated levels of quinolinic acid may play a role in the pathogenesis of psychiatric disorders as well. For instance, increased concentrations have been observed in patients suffering from depression and schizophrenia. This correlation suggests that quinolinic acid could be a potential biomarker for mental health conditions, providing insights into their underlying mechanisms and aiding in the development of targeted treatments.Moreover, quinolinic acid acts as an agonist for the NMDA receptor, which is critical for synaptic plasticity and memory function. While this receptor activity is essential for normal cognitive processes, excessive activation by quinolinic acid can lead to detrimental effects, exacerbating conditions like dementia. Therefore, understanding the dual nature of quinolinic acid—as both a necessary component of brain function and a potential neurotoxin—is vital for advancing our knowledge in neuroscience.In conclusion, quinolinic acid is a compound that exemplifies the intricate balance between beneficial and harmful effects within the human body. Ongoing research is necessary to fully elucidate its roles in both neurological and psychiatric disorders. By exploring the pathways and mechanisms associated with quinolinic acid, scientists hope to pave the way for innovative treatments that can mitigate its neurotoxic effects while harnessing its potential benefits. As we continue to unravel the complexities of this enigmatic molecule, we move closer to understanding the delicate interplay of metabolites in maintaining brain health and addressing neurodegenerative diseases.

喹啉酸是氨基酸色氨酸的代谢产物，近年来由于其在多种生物过程中的复杂作用而引起了广泛关注。作为犬尿喹啉途径的产物，喹啉酸在体内合成，并参与多种神经功能。它以其神经毒性著称，这可能会促进阿尔茨海默病和亨廷顿病等神经退行性疾病的进展。理解喹啉酸对研究人员开发针对这些严重疾病的治疗策略至关重要。喹啉酸的生物合成始于色氨酸，通过酶色氨酸-2,3-双加氧酶（IDO）的作用转化为犬尿喹啉。这个过程受到严格调控，并且可以受到炎症和压力等多种因素的影响。一旦形成犬尿喹啉，它可以进一步代谢为其他几种化合物，包括喹啉酸。喹啉酸在大脑中的积累与兴奋性毒性相关，这一过程是指神经元的过度刺激导致细胞损伤和死亡。研究表明，升高的喹啉酸水平可能在精神疾病的发病机制中发挥作用。例如，抑郁症和精神分裂症患者的体内观察到了浓度增加。这一相关性表明，喹啉酸可能成为心理健康状况的潜在生物标志物，为揭示其潜在机制提供了见解，并有助于开发针对性的治疗方案。此外，喹啉酸作为NMDA受体的激动剂，该受体对于突触可塑性和记忆功能至关重要。尽管这种受体活性对于正常的认知过程是必需的，但喹啉酸的过度激活可能导致有害的后果，加剧痴呆等疾病。因此，理解喹啉酸的双重性质——既是大脑功能的必要组成部分，又可能是神经毒素——对于推进我们在神经科学领域的知识至关重要。总之，喹啉酸是一个展示人体内有益与有害效应之间微妙平衡的化合物。继续研究是完全阐明其在神经和精神疾病中作用的必要条件。通过探索与喹啉酸相关的途径和机制，科学家们希望为创新治疗铺平道路，以减轻其神经毒性效应，同时利用其潜在的益处。随着我们继续揭开这一神秘分子的复杂性，我们离理解代谢物在维持大脑健康和应对神经退行性疾病中的微妙相互作用又近了一步。