partition coefficient

简明释义

配分系数

英英释义

例句

1.In pharmacokinetics, the partition coefficient is used to estimate absorption rates.

在药代动力学中，分配系数用于估算吸收速率。

2.We calculated the partition coefficient to assess the environmental impact of the chemical.

我们计算了分配系数以评估该化学物质对环境的影响。

3.The partition coefficient helps predict how a substance will behave in different solvents.

通过分配系数可以预测物质在不同溶剂中的行为。

4.The partition coefficient is crucial in determining how a drug distributes in the body.

在确定药物在体内分布时，分配系数是至关重要的。

5.A higher partition coefficient usually indicates greater lipophilicity.

较高的分配系数通常表示更强的脂溶性。

作文

The concept of the partition coefficient is fundamental in various scientific fields, particularly in chemistry and pharmacology. It refers to the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium. This concept is crucial for understanding how substances distribute themselves in different environments. For instance, when a drug is administered into the body, its partition coefficient can determine how well it will permeate cell membranes and reach its target site. A higher partition coefficient indicates that a substance is more lipophilic (fat-loving), which often correlates with better absorption in biological systems.In practical applications, the partition coefficient is used to predict the behavior of chemicals in the environment. For example, if a pollutant has a high partition coefficient, it is likely to accumulate in fatty tissues of organisms or in sediments rather than remaining dissolved in water. This accumulation can lead to toxic effects in wildlife and humans alike, making the partition coefficient a critical parameter in environmental risk assessments.Moreover, the partition coefficient is also employed in the field of drug design. Pharmaceutical scientists utilize this parameter to optimize drug formulations. By adjusting the chemical structure of a drug molecule, they can enhance its partition coefficient, thereby improving its efficacy and reducing side effects. For example, a drug with an optimal partition coefficient will be able to cross the blood-brain barrier effectively, which is essential for treating neurological conditions.Understanding the partition coefficient also aids researchers in developing better methods for drug delivery. Nanoparticles, for instance, can be engineered to have specific partition coefficients to ensure that they deliver drugs to the right location within the body. This targeted approach not only enhances the therapeutic effect but also minimizes potential side effects associated with systemic drug distribution.In conclusion, the partition coefficient is a vital concept that spans multiple disciplines, from environmental science to pharmacology. Its implications are far-reaching, affecting everything from drug development to ecological assessments. As scientists continue to explore the intricacies of chemical behavior in various systems, the partition coefficient will remain a key factor in understanding and predicting outcomes in both health and environmental contexts.

“分配系数”的概念在多个科学领域中都是基础，特别是在化学和药理学中。它指的是在平衡状态下，两种不可混溶相中化合物浓度的比率。这个概念对于理解物质如何在不同环境中分布至关重要。例如，当药物被施用于体内时，它的“分配系数”可以决定它在细胞膜中的渗透能力以及到达目标部位的效果。较高的“分配系数”表明一种物质更具亲脂性（喜脂），这通常与生物系统中的更好吸收相关。在实际应用中，“分配系数”被用来预测化学物质在环境中的行为。例如，如果某种污染物具有较高的“分配系数”，那么它可能会在生物体的脂肪组织或沉积物中积累，而不是保持在水中溶解。这种积累可能导致野生动物和人类的毒性效应，使得“分配系数”成为环境风险评估中的关键参数。此外，“分配系数”也被用于药物设计领域。制药科学家利用这个参数来优化药物配方。通过调整药物分子的化学结构，他们可以增强其“分配系数”，从而提高疗效并减少副作用。例如，具有最佳“分配系数”的药物能够有效穿越血脑屏障，这对于治疗神经系统疾病至关重要。理解“分配系数”还帮助研究人员开发更好的药物递送方法。例如，纳米颗粒可以被设计成具有特定的“分配系数”，以确保它们将药物递送到体内的正确位置。这种靶向方法不仅增强了治疗效果，还最小化了与全身药物分布相关的潜在副作用。总之，“分配系数”是一个重要的概念，跨越多个学科，从环境科学到药理学。它的影响深远，涉及从药物开发到生态评估的方方面面。随着科学家们继续探索化学行为在各种系统中的复杂性，“分配系数”将在理解和预测健康与环境背景下的结果中保持关键作用。