metachromatic stain

简明释义

异染性染料

英英释义

例句

1.Researchers often rely on metachromatic stains to differentiate between different types of cells in a sample.

研究人员通常依赖于变色染色来区分样本中的不同类型细胞。

2.The laboratory protocol included using a metachromatic stain for identifying nucleic acids.

实验室协议中包括使用变色染色来识别核酸。

3.In microbiology, a metachromatic stain can help visualize bacterial structures that are otherwise difficult to see.

在微生物学中，变色染色可以帮助可视化其他难以看到的细菌结构。

4.During the experiment, we observed that the metachromatic stain changed color when applied to certain tissues.

在实验过程中，我们观察到当应用于某些组织时，变色染色会改变颜色。

5.The histologist used a metachromatic stain to highlight the presence of mast cells in the tissue sample.

组织学家使用了变色染色来突出组织样本中肥大细胞的存在。

作文

In the field of histology, one of the most fascinating techniques used for visualizing cellular structures is the application of a metachromatic stain. This type of staining is particularly important because it allows scientists to distinguish different types of cells and their components based on their chemical properties. The term metachromatic stain refers to a specific category of dyes that change color when they bind to certain cellular components, providing a contrast that is essential for microscopic examination. The principle behind metachromatic stain lies in its interaction with polyanionic substances, such as nucleic acids and glycosaminoglycans. When these substances are present in a tissue sample, they can cause the dye to exhibit a color shift, which is the hallmark of metachromasia. For instance, the well-known dye toluidine blue O is often used as a metachromatic stain because it can appear blue when bound to certain tissues but may shift to purple or even red depending on the concentration of the binding sites. This property makes it an invaluable tool for pathologists and researchers alike.One of the most significant applications of metachromatic stain is in the study of mast cells, which are known for their role in allergic reactions and inflammation. These cells contain granules filled with heparin and histamine, both of which are polyanionic in nature. When a tissue section containing mast cells is stained with a metachromatic stain, the granules change color, allowing for easy identification under a microscope. This ability to visualize mast cells is crucial for understanding various medical conditions, including allergies and autoimmune diseases.Furthermore, metachromatic stain has applications beyond just mast cell identification. It is also used in the detection of other cell types and structures, such as cartilage and certain types of tumors. For example, in the diagnosis of certain cancers, pathologists may use metachromatic stain to highlight the presence of mucins, which are often produced in excess by malignant cells. By examining the color changes induced by the stain, they can gain insights into the nature of the tumor and its potential behavior.In addition to its diagnostic applications, the use of metachromatic stain in research has expanded our understanding of cellular biology. Researchers utilize this staining technique to investigate the distribution and localization of specific molecules within cells. By employing metachromatic stain in combination with other techniques, such as immunofluorescence, scientists can create a more comprehensive picture of cellular function and organization.In conclusion, the metachromatic stain is an essential tool in both clinical and research settings. Its unique ability to change color in response to specific cellular components not only aids in the identification of various cell types but also enhances our understanding of complex biological processes. As techniques continue to evolve, the significance of metachromatic stain will undoubtedly remain a cornerstone in the study of histology and pathology, contributing to advancements in medical science and diagnostics.

在组织学领域，用于可视化细胞结构的最迷人技术之一是应用变色染色。这种类型的染色特别重要，因为它使科学家能够根据细胞及其成分的化学性质区分不同类型的细胞。术语变色染色指的是一种特定类别的染料，当它与某些细胞成分结合时会改变颜色，从而提供显微镜检查所需的对比。变色染色的原理在于其与多阴离子物质（如核酸和糖胺聚糖）的相互作用。当这些物质存在于组织样本中时，它们可以导致染料表现出颜色变化，这就是变色性的标志。例如，著名的染料美蓝O常被用作变色染色，因为它在与某些组织结合时可能呈现蓝色，但根据结合位点的浓度可能会转变为紫色甚至红色。这种特性使其成为病理学家和研究人员不可或缺的工具。变色染色的一个重要应用是在肥大细胞的研究中，这些细胞因其在过敏反应和炎症中的作用而闻名。这些细胞含有充满肝素和组胺的颗粒，这两者都是多阴离子性质的。当含有肥大细胞的组织切片用变色染色染色时，颗粒会改变颜色，从而便于在显微镜下识别。可视化肥大细胞的能力对于理解各种医学条件，包括过敏和自身免疫疾病至关重要。此外，变色染色的应用不仅限于肥大细胞识别。它还用于检测其他细胞类型和结构，如软骨和某些类型的肿瘤。例如，在某些癌症的诊断中，病理学家可能使用变色染色来突出黏蛋白的存在，这通常由恶性细胞过量产生。通过检查染色引起的颜色变化，他们可以深入了解肿瘤的性质及其潜在行为。除了其诊断应用外，变色染色在研究中的使用也扩大了我们对细胞生物学的理解。研究人员利用这种染色技术调查特定分子在细胞内的分布和定位。通过将变色染色与其他技术（如免疫荧光）结合使用，科学家可以更全面地了解细胞功能和组织。总之，变色染色是临床和研究环境中必不可少的工具。其独特的能力在于响应特定细胞成分而改变颜色，不仅有助于识别各种细胞类型，还增强了我们对复杂生物过程的理解。随着技术的不断发展，变色染色的重要性无疑将继续作为组织学和病理学研究的基石，为医学科学和诊断的进步做出贡献。