matrix effect

简明释义

基体效应

英英释义

例句

1.The presence of other compounds in the sample can lead to a significant matrix effect (基质效应) that alters the accuracy of the analytical results.

样品中其他化合物的存在可能导致显著的基质效应，这会改变分析结果的准确性。

2.In mass spectrometry, the matrix effect (基质效应) can enhance or suppress ionization of target analytes.

在质谱分析中，基质效应可以增强或抑制目标分析物的电离。

3.Researchers need to account for the matrix effect (基质效应) when developing new testing methodologies.

研究人员在开发新测试方法时需要考虑基质效应。

4.The matrix effect (基质效应) was observed in the calibration curves, indicating interference from sample components.

在标定曲线中观察到了基质效应，这表明样品成分的干扰。

5.To minimize the matrix effect (基质效应), sample preparation protocols were optimized.

为了最小化基质效应，优化了样品准备流程。

作文

The term matrix effect refers to the influence that the surrounding environment or matrix has on the measurement of a particular analyte in analytical chemistry. This phenomenon can significantly alter the results obtained from various analytical techniques, leading to potential inaccuracies. In many cases, the matrix effect can either enhance or suppress the signal of the analyte being measured, making it crucial for chemists and analysts to understand and account for this effect in their work. For instance, when analyzing a complex biological sample such as blood or urine, the presence of other substances can interfere with the detection of specific drugs or metabolites. The matrix effect can arise from various components in the sample, including proteins, salts, and other small molecules that may compete with the analyte for detection. As a result, without proper calibration and validation, the measured concentration of the target analyte may not accurately reflect its true level in the sample. To mitigate the impact of the matrix effect, analysts often employ several strategies. One common approach is the use of standard addition methods, where known quantities of the analyte are added to the sample to assess how the matrix influences the measurement. By comparing the response of the sample with and without the added analyte, analysts can better understand the extent of the matrix effect and make necessary adjustments to their calculations. Another strategy involves the use of matrix-matched calibrators, which are samples that closely resemble the composition of the actual samples being analyzed. By preparing calibration standards that mimic the matrix of the sample, analysts can obtain more accurate readings that account for the matrix effect. This practice is particularly important in fields such as pharmacokinetics and toxicology, where precise measurements are essential for patient safety and effective treatment. Moreover, the matrix effect is not limited to biological samples; it can also occur in environmental analysis, food testing, and other areas where complex matrices are involved. For example, when assessing the levels of contaminants in soil or water, the presence of various organic and inorganic substances can skew the results. Understanding the matrix effect in these contexts is vital for regulatory compliance and environmental protection. In conclusion, the matrix effect is a critical concept in analytical chemistry that highlights the importance of recognizing and addressing the influences of the sample matrix on measurement outcomes. By employing appropriate strategies to minimize the impact of the matrix effect, analysts can ensure more reliable and accurate results, ultimately leading to better decision-making in various scientific and practical applications. The awareness and understanding of the matrix effect are essential for anyone working in analytical laboratories, as it plays a significant role in the validity of their findings and the integrity of their work.

术语matrix effect指的是周围环境或基质对分析化学中特定分析物测量的影响。这种现象可以显著改变从各种分析技术中获得的结果，导致潜在的不准确性。在许多情况下，matrix effect可以增强或抑制被测分析物的信号，因此化学家和分析师必须理解并考虑这一效应。例如，在分析复杂的生物样品，如血液或尿液时，其他物质的存在可能会干扰特定药物或代谢物的检测。matrix effect可能来自样品中的各种成分，包括蛋白质、盐和其他小分子，这些成分可能与分析物竞争检测。因此，如果没有适当的校准和验证，测得的目标分析物浓度可能无法准确反映其在样品中的真实水平。为了减轻matrix effect的影响，分析师通常采用几种策略。一种常见的方法是使用标准加入法，即向样品中添加已知数量的分析物，以评估基质对测量的影响。通过比较样品中添加和未添加分析物的响应，分析师可以更好地理解matrix effect的程度，并对其计算进行必要的调整。另一种策略是使用与样品矩阵匹配的校准剂，这些样品与被分析的实际样品的成分非常相似。通过准备与样品矩阵相似的校准标准，分析师可以获得更准确的读数，从而考虑到matrix effect。这种做法在药代动力学和毒理学等领域尤其重要，因为精确的测量对患者安全和有效治疗至关重要。此外，matrix effect不仅限于生物样品；它也可能发生在环境分析、食品检测和其他涉及复杂基质的领域。例如，在评估土壤或水中污染物的水平时，各种有机和无机物质的存在可能会扭曲结果。在这些背景下理解matrix effect对于合规性和环境保护至关重要。总之，matrix effect是分析化学中的一个关键概念，强调了认识和处理样品基质对测量结果影响的重要性。通过采用适当的策略来最小化matrix effect的影响，分析师可以确保更可靠和准确的结果，最终在各种科学和实际应用中做出更好的决策。对matrix effect的意识和理解对于任何在分析实验室工作的人来说都是必不可少的，因为它在发现的有效性和工作的完整性中发挥着重要作用。