aristolochic acid

简明释义

马兜铃酸

英英释义

例句

1.The herbal remedy contained aristolochic acid 马兜铃酸, which raised concerns among health professionals.

这种草药疗法含有马兜铃酸，引起了健康专业人士的担忧。

2.The research focused on the toxic effects of aristolochic acid 马兜铃酸 in kidney cells.

该研究集中于马兜铃酸在肾细胞中的毒性影响。

3.Regulatory agencies have banned products containing aristolochic acid 马兜铃酸 due to safety concerns.

由于安全原因，监管机构已禁止含有马兜铃酸的产品。

4.Studies indicate that long-term consumption of aristolochic acid 马兜铃酸 can lead to cancer.

研究表明，长期消费马兜铃酸可能导致癌症。

5.Patients exposed to aristolochic acid 马兜铃酸 have shown signs of nephropathy.

接触过马兜铃酸的患者表现出肾病的迹象。

作文

Aristolochic acid, a naturally occurring compound found in several plants of the Aristolochia genus, has gained significant attention in the fields of medicine and toxicology. This compound is particularly notable for its nephrotoxic and carcinogenic properties. In recent years, research has revealed that exposure to aristolochic acid can lead to serious health issues, including kidney damage and an increased risk of cancer. The history of aristolochic acid usage dates back centuries, where it was commonly used in traditional medicine systems, particularly in Asian cultures. However, as scientific understanding of its effects has evolved, many countries have restricted or banned the use of plants containing this compound.The mechanism by which aristolochic acid exerts its toxic effects involves the formation of DNA adducts, which are pieces of DNA covalently bonded to a cancer-causing chemical. This interaction can lead to mutations and ultimately, tumor formation. Studies have shown that individuals who have ingested herbal products containing aristolochic acid are at a higher risk for developing urothelial carcinoma, a type of cancer affecting the urinary tract. Furthermore, the nephrotoxic effects of aristolochic acid can manifest as chronic kidney disease, leading to severe health complications and even renal failure.Despite its dangers, aristolochic acid continues to be of interest in pharmacological research due to its unique chemical structure and potential therapeutic applications. Some researchers are investigating whether modified forms of aristolochic acid could be utilized in drug development, aiming to harness its properties while minimizing toxicity. This highlights the delicate balance in pharmacology between utilizing natural compounds for their benefits while being mindful of their potential risks.Public awareness surrounding aristolochic acid has increased, prompting discussions about the safety of herbal medicines. Many people assume that natural products are inherently safe; however, the case of aristolochic acid serves as a cautionary tale. It underscores the importance of rigorous scientific evaluation of herbal remedies and the need for regulatory oversight to protect consumers from harmful substances.In conclusion, aristolochic acid is a potent compound with significant implications for human health. While it has a historical context in traditional medicine, modern science has revealed its potential dangers, necessitating a careful approach to its use. As research continues, it is crucial to educate the public about the risks associated with aristolochic acid and to promote safe practices when it comes to herbal medicine consumption. Only through informed choices can we ensure our health and well-being in an increasingly complex world of natural products and pharmaceuticals.

马兜铃酸是几种马兜铃属植物中发现的一种天然化合物，在医学和毒理学领域引起了显著关注。这种化合物因其肾毒性和致癌特性而尤其引人注目。近年来，研究表明，接触马兜铃酸可能导致严重的健康问题，包括肾脏损伤和癌症风险增加。马兜铃酸的使用历史可以追溯到几个世纪以前，当时它在传统医学体系中被广泛使用，特别是在亚洲文化中。然而，随着对其影响的科学理解的发展，许多国家已限制或禁止使用含有该化合物的植物。马兜铃酸的毒性作用机制涉及DNA加合物的形成，即与致癌化学物质共价结合的DNA片段。这种相互作用可能导致突变，最终形成肿瘤。研究表明，摄入含有马兜铃酸的草药产品的人群，患上尿路上皮癌的风险更高，这是一种影响尿道的癌症。此外，马兜铃酸的肾毒性效应可能表现为慢性肾病，导致严重的健康并发症甚至肾功能衰竭。尽管存在危险，马兜铃酸在药理学研究中仍然受到关注，因为它独特的化学结构和潜在的治疗应用。一些研究人员正在调查改良形式的马兜铃酸是否可以用于药物开发，旨在利用其特性，同时最小化毒性。这突显了药理学中利用天然化合物的益处与关注其潜在风险之间的微妙平衡。公众对马兜铃酸的认识有所提高，促使人们讨论草药的安全性。许多人认为天然产品天生安全；然而，马兜铃酸的案例则是一个警示故事。它强调了对草药疗法进行严格科学评估的重要性，以及需要监管监督以保护消费者免受有害物质侵害。总之，马兜铃酸是一种对人类健康具有重大影响的强效化合物。虽然它在传统医学中有历史背景，但现代科学揭示了其潜在危险，因此对其使用需要谨慎处理。随着研究的继续，教育公众关于马兜铃酸相关风险是至关重要的，并促进安全的草药消费实践。只有通过明智的选择，我们才能确保在日益复杂的自然产品和药物世界中保持健康和福祉。