threshold dose

简明释义

临界剂量

英英释义

例句

1.Researchers are investigating the threshold dose that triggers a response in the immune system.

研究人员正在调查触发免疫系统反应的阈值剂量。

2.It is crucial to identify the threshold dose for safe medication administration.

确定安全用药的阈值剂量至关重要。

3.The study determined the threshold dose for the drug to be effective in treating the condition.

研究确定该药物在治疗该病症时的阈值剂量。

4.The threshold dose for toxicity varies between individuals.

毒性阈值剂量因个体而异。

5.Patients should not exceed the threshold dose to avoid adverse effects.

患者不应超过阈值剂量以避免不良反应。

作文

In the field of pharmacology and toxicology, the term threshold dose refers to the minimum amount of a substance that produces a noticeable effect in an organism. Understanding this concept is crucial for both drug development and safety assessments. The threshold dose can vary significantly among different individuals due to factors such as age, sex, genetic predisposition, and overall health. For instance, what may be a safe threshold dose for one person could be harmful to another due to differences in metabolism and sensitivity to certain compounds.The significance of identifying the threshold dose lies not only in therapeutic contexts but also in environmental health. For example, when assessing the risks associated with exposure to pollutants, scientists often determine the threshold dose at which adverse effects begin to occur. This helps regulatory agencies set safety standards to protect public health. If the exposure level remains below the threshold dose, individuals are generally considered to be at low risk of experiencing negative health effects.Moreover, the concept of the threshold dose is essential when it comes to understanding how certain drugs work. Many medications have a specific threshold dose that must be reached to achieve therapeutic effects. For example, antibiotics need to be taken at doses that exceed the threshold dose to effectively eliminate bacterial infections. Conversely, taking doses below the threshold dose may not only fail to provide the desired outcome but could also contribute to the development of antibiotic resistance.In clinical trials, establishing the threshold dose is a critical step in determining the efficacy and safety of new medications. Researchers conduct various studies to find the threshold dose that maximizes therapeutic benefits while minimizing side effects. This process often involves a range of doses to ascertain where the body begins to respond positively to the treatment and where adverse reactions might occur.Understanding the threshold dose also plays a vital role in the field of nutrition. Nutrients, vitamins, and minerals all have specific threshold doses necessary for optimal health. For instance, while vitamin D is essential for bone health, excessive intake can lead to toxicity. Therefore, knowing the threshold dose for each nutrient helps individuals maintain a balanced diet without risking their health.In conclusion, the concept of threshold dose is fundamental across various disciplines, including medicine, environmental science, and nutrition. By comprehending the threshold dose, we can make informed decisions about drug usage, environmental exposure, and dietary choices. This knowledge ultimately contributes to better health outcomes and enhances our understanding of how substances interact with biological systems. As research continues to evolve, the importance of accurately determining the threshold dose will remain a priority in ensuring safety and efficacy in health-related fields.

在药理学和毒理学领域，术语阈值剂量指的是产生明显效果所需的最小物质量。理解这一概念对药物开发和安全评估至关重要。阈值剂量因个体差异而异，受年龄、性别、遗传倾向和整体健康状况等因素的影响。例如，对一个人来说安全的阈值剂量可能对另一个人有害，因为他们在代谢和对某些化合物的敏感性方面存在差异。确定阈值剂量的重要性不仅体现在治疗背景中，也体现在环境健康中。例如，在评估污染物暴露相关风险时，科学家通常会确定不良影响开始发生的阈值剂量。这有助于监管机构设定安全标准，以保护公众健康。如果暴露水平保持在阈值剂量以下，通常认为个体面临的负面健康影响风险较低。此外，阈值剂量的概念在理解某些药物的作用机制时也至关重要。许多药物都有特定的阈值剂量，必须达到才能实现治疗效果。例如，抗生素需要以超过阈值剂量的剂量服用，才能有效消除细菌感染。相反，服用低于阈值剂量的剂量不仅可能无法提供预期的结果，还可能导致抗生素耐药性的产生。在临床试验中，建立阈值剂量是确定新药物疗效和安全性的关键步骤。研究人员进行各种研究，以找出最大化治疗效果并最小化副作用的阈值剂量。这个过程通常涉及一系列剂量，以确定身体在何处开始对治疗产生积极反应，以及何处可能出现不良反应。理解阈值剂量在营养学领域同样扮演着重要角色。营养素、维生素和矿物质都有特定的阈值剂量，对于最佳健康至关重要。例如，虽然维生素D对骨骼健康很重要，但过量摄入可能导致毒性。因此，了解每种营养素的阈值剂量有助于个人保持均衡饮食，而不危及健康。总之，阈值剂量的概念在医学、环境科学和营养等多个学科中都是基础。通过理解阈值剂量，我们可以就药物使用、环境暴露和饮食选择做出明智的决策。这种知识最终有助于改善健康结果，并增强我们对物质与生物系统相互作用的理解。随着研究的不断发展，准确确定阈值剂量的重要性将始终是确保健康相关领域安全性和有效性的优先事项。