mean lethal dose

简明释义

平均致死剂量

英英释义

例句

1.Understanding the mean lethal dose 平均致死剂量 is crucial for toxicology studies.

理解mean lethal dose 平均致死剂量对毒理学研究至关重要。

2.Pharmaceutical companies must determine the mean lethal dose 平均致死剂量 of new drugs during clinical trials.

制药公司在临床试验中必须确定新药的mean lethal dose 平均致死剂量。

3.The mean lethal dose 平均致死剂量 of arsenic was found to be significantly lower than previously thought.

发现砷的mean lethal dose 平均致死剂量明显低于之前的估计。

4.Environmental scientists often study the mean lethal dose 平均致死剂量 of pollutants to understand their effects on wildlife.

环境科学家经常研究污染物的mean lethal dose 平均致死剂量以了解其对野生动物的影响。

5.The researchers calculated the mean lethal dose 平均致死剂量 of the new pesticide to assess its safety.

研究人员计算了新农药的mean lethal dose 平均致死剂量以评估其安全性。

作文

In the study of toxicology, the term mean lethal dose refers to the amount of a substance that is sufficient to cause death in a certain percentage of a population. This measurement is crucial for understanding the potential dangers of various chemicals, drugs, and environmental toxins. The mean lethal dose is often abbreviated as LD50, which represents the dose required to kill half (50%) of a test population, usually laboratory animals like rats or mice. By determining the mean lethal dose, researchers can evaluate the toxicity of substances and establish safety guidelines for human exposure.The concept of mean lethal dose is essential in pharmacology, where it helps in assessing the safety of new medications before they are approved for public use. For instance, if a new drug shows a low mean lethal dose, it indicates a higher level of safety for patients. Conversely, a high mean lethal dose suggests that the drug could be dangerous if misused or taken in excessive amounts. Therefore, understanding this measurement is vital for both healthcare providers and patients.Moreover, the mean lethal dose is not only relevant in medicine but also in environmental science. It plays a significant role in evaluating the impact of pollutants on wildlife and ecosystems. For example, industrial waste or agricultural chemicals can have varying levels of toxicity, and knowing their mean lethal dose helps scientists predict how these substances might affect different species. This information is crucial for developing regulations to protect both human health and the environment.The methodology used to determine the mean lethal dose typically involves administering different doses of a substance to groups of test animals and observing the effects. Researchers calculate the mean lethal dose based on the dose at which 50% of the subjects die within a specified period. This process requires careful ethical considerations, as it involves the use of live animals and necessitates adherence to strict guidelines to minimize suffering.In addition to its application in toxicology, the mean lethal dose has implications in fields such as forensic science, where it can help determine the cause of death in poisoning cases. By comparing the levels of toxins found in a deceased individual with established mean lethal dose values, forensic experts can ascertain whether a substance contributed to the death and potentially identify foul play.Overall, the mean lethal dose is a vital concept that intersects various disciplines, from medicine to environmental science and forensic investigations. Its importance cannot be overstated, as it provides a quantitative measure of toxicity that aids in safeguarding public health and ensuring the responsible use of chemicals. As research continues to evolve, the methodologies for determining the mean lethal dose are likely to become more refined, leading to better safety protocols and a deeper understanding of the risks associated with different substances. Thus, grasping the implications of the mean lethal dose is essential for anyone involved in health sciences, environmental protection, or regulatory affairs.

在毒理学研究中，“mean lethal dose”一词指的是足以导致一定比例人群死亡的物质数量。这个测量对于理解各种化学品、药物和环境毒素的潜在危险至关重要。“mean lethal dose”通常缩写为LD50，表示杀死一半（50%）实验人群所需的剂量，通常是实验室动物如老鼠或小鼠。通过确定“mean lethal dose”，研究人员可以评估物质的毒性并建立人类接触的安全指南。“mean lethal dose”的概念在药理学中至关重要，它有助于在新药获得公众使用批准之前评估其安全性。例如，如果一种新药显示出较低的“mean lethal dose”，则表明对患者的安全性较高。相反，较高的“mean lethal dose”则表明该药物在误用或过量服用时可能是危险的。因此，理解这一测量对于医疗提供者和患者来说都是至关重要的。此外，“mean lethal dose”不仅在医学上相关，在环境科学中也发挥着重要作用。它在评估污染物对野生动物和生态系统影响方面起着重要作用。例如，工业废物或农业化学品可能具有不同的毒性水平，了解其“mean lethal dose”有助于科学家预测这些物质可能对不同物种造成的影响。这些信息对于制定保护人类健康和环境的法规至关重要。确定“mean lethal dose”的方法通常涉及将不同剂量的物质施加于实验动物组，并观察其效果。研究人员根据在特定时间内死亡的50%受试者的剂量计算“mean lethal dose”。这个过程需要仔细的伦理考虑，因为它涉及使用活体动物，并需要遵循严格的指南以尽量减少痛苦。除了在毒理学中的应用，“mean lethal dose”在法医学领域也有影响，它可以帮助确定中毒案件中的死亡原因。通过将发现的毒素水平与已建立的“mean lethal dose”值进行比较，法医专家可以确定某种物质是否导致了死亡，并可能识别出恶意行为。总之，“mean lethal dose”是一个至关重要的概念，交叉于多个学科，从医学到环境科学再到法医调查。它的重要性不容小觑，因为它提供了一种毒性的定量测量，有助于保护公众健康并确保化学品的负责任使用。随着研究的不断发展，确定“mean lethal dose”的方法可能会变得更加精细，从而导致更好的安全协议和对不同物质风险的更深刻理解。因此，掌握“mean lethal dose”的含义对于任何参与健康科学、环境保护或监管事务的人来说都是至关重要的。