racemize

简明释义

英[ˈræsɪmaɪz]美[reˈsiz]

vt. 外消旋；使外消旋

第 三 人 称 单 数 r a c e m i z e s

现 在 分 词 r a c e m i z i n g

过 去 式 r a c e m i z e d

过 去 分 词 r a c e m i z e d

英英释义

单词用法

同义词

反义词

例句

1.In organic synthesis, it is often necessary to racemize a product to obtain a desired ratio of isomers.

在有机合成中，通常需要使产物形成外消旋体以获得所需的异构体比例。

2.The process to racemize the chiral molecule was complicated and required precise conditions.

将手性分子转化为外消旋体的过程复杂且需要精确的条件。

3.During the reaction, the temperature increased, causing the substance to racemize unexpectedly.

在反应过程中，温度升高，导致该物质意外地形成外消旋体。

4.The chemist was able to racemize the compound to produce both enantiomers.

化学家能够使该化合物形成外消旋体，以产生两种对映体。

5.Researchers are studying how to racemize certain drugs to enhance their efficacy.

研究人员正在研究如何使某些药物形成外消旋体以增强其效力。

作文

In the field of chemistry, the term racemize refers to the process by which an optically active compound is converted into a racemic mixture. This means that a substance that has the ability to rotate plane-polarized light in one direction can be transformed into a mixture containing equal amounts of its enantiomers, which are mirror-image forms of the compound. Understanding the concept of racemize is essential for chemists, especially those working in organic synthesis and pharmaceuticals.The significance of racemize lies in its implications for drug development. Many pharmaceutical compounds are chiral, meaning they exist in two forms that are non-superimposable mirror images of each other. These enantiomers can have very different biological activities. For example, one enantiomer might be therapeutically beneficial, while the other could be inactive or even harmful. When a chiral drug is racemized, the resulting racemic mixture may not exhibit the desired therapeutic effects, leading to complications in treatment.To illustrate this further, consider the case of the drug thalidomide. Initially marketed as a sedative, thalidomide was found to be effective for morning sickness in pregnant women. However, one enantiomer of thalidomide caused severe birth defects, while the other did not. This tragic outcome highlighted the importance of understanding chirality and the potential consequences of racemized compounds in medicine.Moreover, the process of racemizeation can occur unintentionally during chemical reactions or storage. For instance, if a chiral compound is exposed to certain conditions, such as heat or light, it may undergo racemizeation, resulting in a loss of its optical activity. This phenomenon poses challenges for chemists who strive to maintain the integrity of their chiral products throughout the synthesis and storage phases.In laboratory settings, controlling racemizeation is crucial. Chemists employ various strategies to minimize the risk of racemizeation, such as conducting reactions under specific conditions (e.g., low temperatures or inert atmospheres) or using catalysts that favor the formation of one enantiomer over the other. By optimizing these conditions, chemists can enhance the yield of the desired enantiomer and reduce the formation of unwanted racemic mixtures.In summary, the term racemize plays a vital role in the field of chemistry, particularly in the context of chiral compounds and their applications in pharmaceuticals. Understanding the process of racemizeation is essential for chemists to ensure the efficacy and safety of drugs. As we continue to explore the complexities of chiral molecules, the need for precise control over racemizeation will remain a key focus in the development of new therapeutic agents.In conclusion, the concept of racemize is not merely a technical term; it embodies the challenges and responsibilities faced by chemists in their quest to create effective and safe medications. The consequences of racemizeation extend beyond the laboratory, impacting patient care and public health. Therefore, a thorough understanding of this process is imperative for anyone involved in the fields of chemistry and pharmacology.

在化学领域，术语racemize指的是一种光学活性化合物被转化为外消旋混合物的过程。这意味着一种能够以一个方向旋转平面偏振光的物质可以被转化为含有等量其对映体的混合物，而这些对映体是该化合物的镜像形式。理解racemize的概念对于化学家尤其是从事有机合成和制药工作的人来说至关重要。racemize的重要性在于它对药物开发的影响。许多药物化合物是手性的，这意味着它们存在两种形式，这两种形式是不可叠加的镜像。 这些对映体可能具有截然不同的生物活性。例如，一个对映体可能具有治疗效果，而另一个可能无效甚至有害。当一个手性药物被racemize时，所产生的外消旋混合物可能不会表现出所需的治疗效果，从而导致治疗中的并发症。为了进一步说明这一点，考虑一下药物沙利度胺的案例。最初作为镇静剂上市，沙利度胺被发现对孕妇的晨吐有效。然而，沙利度胺的一个对映体导致严重的出生缺陷，而另一个则没有。这一悲惨的结果突显了理解手性及其在医学上racemize化合物潜在后果的重要性。此外，racemize过程可能在化学反应或储存过程中无意中发生。例如，如果一个手性化合物暴露在某些条件下，如热或光，它可能会经历racemize，导致其光学活性的丧失。这种现象给努力在合成和储存阶段保持手性产品完整性的化学家带来了挑战。在实验室环境中，控制racemize至关重要。化学家采用各种策略来最小化racemize的风险，例如在特定条件（例如低温或惰性气氛）下进行反应或使用促进一个对映体形成而非另一个的催化剂。通过优化这些条件，化学家可以提高所需对映体的产率，并减少不必要的外消旋混合物的形成。总之，术语racemize在化学领域中扮演着重要角色，特别是在手性化合物及其在制药中的应用背景下。理解racemize过程对于化学家确保药物的有效性和安全性至关重要。随着我们继续探索手性分子的复杂性，对racemize的精确控制的需求将始终是新治疗剂开发中的关键焦点。最后，racemize的概念不仅仅是一个技术术语；它体现了化学家在创造有效和安全药物方面面临的挑战和责任。racemize的后果超越了实验室，影响着病人护理和公共健康。因此，对于任何参与化学和药理学领域的人来说，深入理解这一过程都是必不可少的。