hydroxylating

简明释义

英[haɪˈdrɒksɪleɪtɪŋ]美[haɪˈdrɑksəˌleɪtɪŋ]

羟基化

羟基化的

英英释义

单词用法

同义词

反义词

例句

1.Research and development for fhe production of pyrocatechol and hydroquinone by reaction of phenol with hydrogen peroxide and percarboxylic acid as hydroxylating reagent are introduced.

着重介绍用过氧化氢和过氧化羧酸作羟基化剂，使苯酚羟基化生成邻苯二酚和对苯二酚的研究开发进展。

2.Research and development for fhe production of pyrocatechol and hydroquinone by reaction of phenol with hydrogen peroxide and percarboxylic acid as hydroxylating reagent are introduced.

着重介绍用过氧化氢和过氧化羧酸作羟基化剂，使苯酚羟基化生成邻苯二酚和对苯二酚的研究开发进展。

3.By hydroxylating the substrate, the reaction rate was significantly increased.

通过羟基化底物，反应速率显著提高。

4.The process of hydroxylating phenols is crucial in organic synthesis.

在有机合成中，羟基化酚类的过程至关重要。

5.Researchers discovered that hydroxylating certain aromatic compounds can improve their biological activity.

研究人员发现，羟基化某些芳香化合物可以提高它们的生物活性。

6.The enzyme is responsible for hydroxylating compounds to enhance their solubility.

该酶负责羟基化化合物以增强其溶解性。

7.During the metabolic process, the liver cells are hydroxylating steroids to regulate their activity.

在代谢过程中，肝细胞正在羟基化类固醇以调节其活性。

作文

The process of drug metabolism is a complex and fascinating subject that involves various biochemical reactions. One of the critical reactions in this process is known as hydroxylating, which refers to the addition of a hydroxyl group (-OH) to a molecule. This reaction plays a significant role in transforming lipophilic compounds into more hydrophilic forms, making them easier for the body to excrete. The importance of hydroxylating cannot be overstated, as it affects the pharmacokinetics of many drugs and can influence their efficacy and safety.In the human body, enzymes known as cytochrome P450s are primarily responsible for hydroxylating various substrates. These enzymes are found predominantly in the liver, where they catalyze the oxidation of organic substances. For instance, when a person ingests a medication, the liver enzymes may hydroxylate the drug, altering its structure and function. This modification can either activate the drug, making it effective, or deactivate it, leading to its elimination from the system.Moreover, the hydroxylating process can vary significantly among individuals due to genetic differences, environmental factors, and the presence of other substances. This variability highlights the importance of personalized medicine, where understanding a patient's unique metabolic profile can lead to more effective treatment plans. For example, some patients may metabolize a drug too quickly due to enhanced hydroxylating activity, resulting in subtherapeutic levels, while others may have reduced activity, leading to toxicity.The implications of hydroxylating extend beyond drug metabolism. In the field of environmental science, hydroxylating reactions also play a pivotal role in the degradation of pollutants. Many environmental contaminants undergo hydroxylating transformations, which can render them less harmful or facilitate their removal from ecosystems. Understanding these processes is crucial for developing strategies to mitigate pollution and protect public health.In conclusion, hydroxylating is a vital biochemical reaction that significantly impacts drug metabolism and environmental chemistry. As research continues to uncover the intricacies of this process, it becomes increasingly clear that both pharmacology and toxicology are deeply intertwined with the principles of hydroxylating. Future studies will likely focus on elucidating the mechanisms behind this reaction and exploring its potential applications in drug development and environmental remediation. By enhancing our understanding of hydroxylating, we can pave the way for innovative therapeutic approaches and more effective strategies for addressing environmental challenges.

药物代谢的过程是一个复杂而迷人的主题，涉及各种生化反应。在这个过程中，一个关键的反应被称为羟基化，指的是向分子中添加羟基（-OH）基团。这个反应在将脂溶性化合物转化为更亲水的形式方面发挥着重要作用，使它们更容易被身体排出。羟基化的重要性不容小觑，因为它影响许多药物的药代动力学，并可能影响其功效和安全性。在人体内，主要负责羟基化各种底物的酶被称为细胞色素P450。这些酶主要存在于肝脏中，在那里它们催化有机物质的氧化。例如，当一个人摄入药物时，肝脏酶可能会对药物进行羟基化，改变其结构和功能。这种修饰可以激活药物，使其有效，或者使其失活，从而导致其从体内排除。此外，由于遗传差异、环境因素和其他物质的存在，羟基化过程在个体之间可能存在显著差异。这种变异性突显了个性化医学的重要性，了解患者独特的代谢特征可以制定更有效的治疗方案。例如，一些患者可能由于增强的羟基化活性而过快代谢药物，导致药物浓度不足，而另一些患者则可能活性降低，导致毒性。羟基化的影响不仅限于药物代谢。在环境科学领域，羟基化反应也在污染物降解中发挥着关键作用。许多环境污染物经历羟基化转化，这可以使它们变得不那么有害或促进其从生态系统中的去除。理解这些过程对于制定减轻污染和保护公众健康的策略至关重要。总之，羟基化是一个重要的生化反应，对药物代谢和环境化学具有重要影响。随着研究不断揭示这一过程的复杂性，越来越清楚的是药理学和毒理学与羟基化的原理深深交织在一起。未来的研究可能将集中于阐明这一反应背后的机制，并探索其在药物开发和环境修复中的潜在应用。通过增强我们对羟基化的理解，我们可以为创新的治疗方法和更有效的应对环境挑战的策略铺平道路。