racemate

简明释义

英[ˈræsɪmeɪt]美[ˈræsəmeɪt]

n. 外消旋酒石酸盐；外消旋酸盐；[植] 外消旋物

英英释义

单词用法

同义词

反义词

例句

1.Pharmacological interactions between the enantiomers may happen when a chiral drug was used as its racemate.

当手性药物以外消旋体供药用时，其对映体间就可能发生药效学和药代动力学的相互作用。

2.They are all chiral molecules and belong in the racemate.

它们都是手性分子，属于外消旋体。

3.Pharmacological interactions between the enantiomers may happen when a chiral drug was used as its racemate.

当手性药物以外消旋体供药用时，其对映体间就可能发生药效学和药代动力学的相互作用。

4.The chemist isolated the racemate 外消旋体 from the reaction mixture to study its properties.

化学家从反应混合物中分离出racemate 外消旋体以研究其性质。

5.The synthesis of the compound produced a racemate 外消旋体 that required further separation to obtain pure enantiomers.

该化合物的合成产生了一个racemate 外消旋体，需要进一步分离以获得纯净的对映体。

6.During the experiment, the researchers found that the racemate 外消旋体 had different solubility characteristics compared to its individual enantiomers.

在实验过程中，研究人员发现racemate 外消旋体与其各个对映体相比具有不同的溶解特性。

7.In asymmetric synthesis, it's crucial to avoid producing a racemate 外消旋体 that could complicate the purification process.

在不对称合成中，避免产生可能使纯化过程复杂化的racemate 外消旋体是至关重要的。

8.The pharmacologist noted that one enantiomer of the drug was effective, while the racemate 外消旋体 showed reduced efficacy.

药理学家指出，该药物的一种对映体有效，而racemate 外消旋体显示出降低的效力。

作文

In the realm of chemistry, particularly in the study of stereochemistry, the term racemate refers to a mixture of equal amounts of two enantiomers. Enantiomers are molecules that are mirror images of each other, much like how our left and right hands are similar yet distinctly different. The concept of racemate is crucial because it highlights the importance of molecular configuration in determining the properties and behaviors of substances. In many cases, one enantiomer can exhibit beneficial effects, while the other may be harmful or inactive. Therefore, understanding racemate mixtures is vital for pharmaceutical development, where the effectiveness and safety of drugs depend on their specific molecular structures.One of the most famous examples of a racemate is thalidomide, which was originally marketed as a sedative in the late 1950s. Thalidomide exists as a racemate, with one enantiomer providing the desired calming effects, while the other caused severe birth defects when taken by pregnant women. This tragic incident underscores the significance of stereochemistry in drug design and the necessity for rigorous testing of enantiomers individually rather than as a racemate. The process of separating enantiomers from a racemate can be quite challenging. Various techniques, such as chiral chromatography and crystallization, are employed to isolate the individual enantiomers for further study or application. By understanding how to manipulate racemate mixtures, chemists can create more effective and safer pharmaceutical products. Additionally, the study of racemate is not limited to pharmaceuticals; it extends to the fields of agriculture, food science, and even fragrance development, where the specific isomer of a compound can greatly influence the final product's effectiveness or appeal.Moreover, the concept of racemate also has implications in environmental science. Many natural compounds exist as racemates, and understanding their behavior in the environment can help us predict how they will interact with ecosystems. For instance, the breakdown of a racemate in soil or water can differ significantly depending on the specific enantiomer present, affecting both the environment and human health. In conclusion, the term racemate encapsulates a fundamental aspect of chemistry that has far-reaching implications across various fields. From its pivotal role in drug development to its influence on environmental interactions, understanding racemate mixtures allows scientists to harness the power of molecular diversity. As research continues to advance, the study of racemate will undoubtedly lead to new discoveries and innovations that can improve our lives and protect our planet. The importance of recognizing and analyzing racemate mixtures cannot be overstated, as they represent a key intersection of science, safety, and sustainability.

在化学领域，特别是在立体化学研究中，术语racemate指的是两种对映体的等量混合物。对映体是彼此的镜像分子，就像我们的左手和右手相似但又明显不同。racemate的概念至关重要，因为它强调了分子构型在决定物质性质和行为中的重要性。在许多情况下，一个对映体可能表现出有益的效果，而另一个则可能有害或无效。因此，理解racemate混合物对于制药开发至关重要，因为药物的有效性和安全性取决于其特定的分子结构。一个著名的racemate例子是沙利度胺，它最初在20世纪50年代末被作为镇静剂上市。沙利度胺以racemate的形式存在，其中一个对映体提供了所需的镇静效果，而另一个在孕妇服用时导致严重的出生缺陷。这一悲惨事件突显了药物设计中立体化学的重要性，以及对单个对映体进行严格测试的必要性，而不是将其作为racemate来处理。从racemate中分离对映体的过程可能相当具有挑战性。各种技术，如手性色谱法和结晶法，常用于分离单个对映体以便进一步研究或应用。通过理解如何操纵racemate混合物，化学家可以创造出更有效和更安全的药物产品。此外，racemate的研究不仅限于制药；它还扩展到农业、食品科学甚至香料开发等领域，在这些领域中，化合物的特定异构体可以极大地影响最终产品的有效性或吸引力。此外，racemate的概念在环境科学中也有重要意义。许多天然化合物以racemate的形式存在，了解它们在环境中的行为可以帮助我们预测它们与生态系统的相互作用。例如，racemate在土壤或水中的降解可能会因特定对映体的存在而显著不同，从而影响环境和人类健康。总之，术语racemate概括了化学的一个基本方面，这在各个领域都有深远的影响。从其在药物开发中的关键作用到对环境相互作用的影响，理解racemate混合物使科学家能够利用分子多样性的力量。随着研究的不断进展，racemate的研究无疑将带来新的发现和创新，改善我们的生活并保护我们的星球。认识和分析racemate混合物的重要性不容低估，因为它们代表了科学、安全和可持续发展的关键交汇点。