proviral

简明释义

英[proʊˈvaɪrəl]美[proʊˈvaɪrəl]

adj. 前病毒的

英英释义

单词用法

同义词

反义词

例句

1.Topical to the discussion of HIV eradication is the biology behind latent infection as well as models for the study of latency and pharmacological approaches to stimulate proviral gene expression.

局部的讨论根除是生物体hiv潜伏感染后的模型，具有多种药理作用的研究方法延迟刺激原病毒基因的表达。

2.Topical to the discussion of HIV eradication is the biology behind latent infection as well as models for the study of latency and pharmacological approaches to stimulate proviral gene expression.

局部的讨论根除是生物体hiv潜伏感染后的模型，具有多种药理作用的研究方法延迟刺激原病毒基因的表达。

3.Objective To assess the feasibility of detection of HIV-1 proviral DNA on Dried Blood Spot (DBS) samples by nested-PCR assay.

目的研究干血斑(DBS)样本用于人类免疫缺陷病毒1型(HIV - 1)感染前病毒DNA基因诊断的可行性。

4.Understanding the proviral 前病毒的 integration process is crucial for developing effective treatments.

理解前病毒的整合过程对开发有效治疗至关重要。

5.The drug targets proviral 前病毒的 pathways to inhibit viral replication.

这种药物针对前病毒的途径以抑制病毒复制。

6.In HIV research, proviral 前病毒的 DNA serves as a reservoir for the virus.

在HIV研究中，前病毒的 DNA作为病毒的储库。

7.Scientists discovered that certain genes can enhance proviral 前病毒的 activity in host cells.

科学家发现某些基因可以增强宿主细胞中前病毒的活性。

8.The research focused on the role of proviral 前病毒的 DNA in the replication of the virus.

这项研究集中于前病毒的 DNA 在病毒复制中的作用。

作文

In the study of virology, the term proviral refers to the state of a viral genome that has integrated into the host cell's DNA. This integration can lead to various outcomes for both the virus and the host. Understanding the concept of proviral states is crucial for researchers who are developing treatments for viral infections, particularly in cases like HIV, where the virus can remain dormant within the host's genome for extended periods. When a virus infects a cell, it typically hijacks the cellular machinery to replicate itself. In some cases, however, the viral genetic material becomes integrated into the host's DNA, resulting in a proviral form. This means that the virus can remain hidden from the immune system and persist within the host for years without causing any symptoms. This long-term persistence poses significant challenges for treatment, as the proviral DNA can reactivate and produce new viral particles when conditions are favorable.The implications of proviral states extend beyond just the persistence of the virus. It also affects how the immune system responds to the infection. The presence of proviral DNA can lead to an incomplete immune response, allowing the virus to evade detection. This is particularly problematic in chronic infections, where the immune system is unable to clear the virus effectively. Researchers are exploring various strategies to target proviral reservoirs in order to eliminate latent infections and achieve a functional cure.Moreover, understanding the mechanisms that govern proviral integration can provide insights into viral evolution and pathogenesis. For example, certain viral proteins play a critical role in facilitating the integration process, and studying these proteins can reveal potential targets for antiviral therapies. By disrupting the lifecycle of the virus at the proviral stage, scientists hope to develop more effective treatments that can eradicate the virus from infected individuals.In addition to therapeutic applications, the concept of proviral states is also relevant in the field of gene therapy. Scientists have been investigating the use of proviral vectors to deliver therapeutic genes into host cells. By leveraging the ability of certain viruses to integrate their genetic material into the host genome, researchers aim to develop innovative treatments for genetic disorders and other diseases.In conclusion, the term proviral encapsulates a significant aspect of viral behavior and interaction with host cells. Its implications stretch across various fields of research, including virology, immunology, and gene therapy. A deeper understanding of proviral states will not only aid in the development of more effective antiviral therapies but also enhance our overall comprehension of viral biology and its impact on human health. As we continue to advance our knowledge in this area, the fight against viral infections will become increasingly sophisticated, paving the way for improved outcomes for patients worldwide.

在病毒学研究中，术语proviral指的是病毒基因组整合到宿主细胞DNA中的状态。这种整合可能导致病毒和宿主的多种结果。理解proviral状态的概念对开发病毒感染治疗的研究人员至关重要，尤其是在HIV等病例中，病毒可以在宿主基因组中保持休眠很长时间。当病毒感染细胞时，通常会劫持细胞机制来复制自身。然而，在某些情况下，病毒遗传物质会整合到宿主DNA中，形成proviral形式。这意味着病毒可以在免疫系统的隐蔽下存活，并在宿主体内持续多年而不引起任何症状。这种长期的持续性给治疗带来了重大挑战，因为proviral DNA可以在有利条件下重新激活并产生新的病毒颗粒。proviral状态的影响不仅限于病毒的持续性。它还影响免疫系统对感染的反应。proviral DNA的存在可能导致免疫反应不完全，使病毒能够逃避检测。这在慢性感染中尤为成问题，免疫系统无法有效清除病毒。研究人员正在探索各种策略，以针对proviral储存库，从而消除潜伏感染，实现功能性治愈。此外，理解控制proviral整合的机制可以提供有关病毒进化和致病性的见解。例如，某些病毒蛋白在促进整合过程中发挥关键作用，研究这些蛋白可以揭示抗病毒疗法的潜在靶点。通过在proviral阶段破坏病毒的生命周期，科学家希望开发出更有效的治疗方法，以根除感染个体体内的病毒。除了治疗应用外，proviral状态的概念在基因治疗领域也具有相关性。科学家们一直在研究使用proviral载体将治疗基因递送到宿主细胞中。通过利用某些病毒将其遗传物质整合到宿主基因组中的能力，研究人员旨在开发用于遗传疾病和其他疾病的创新治疗方法。总之，术语proviral概括了病毒行为及其与宿主细胞相互作用的重要方面。它的影响跨越病毒学、免疫学和基因治疗等多个研究领域。对proviral状态的深入理解不仅将有助于开发更有效的抗病毒疗法，还将增强我们对病毒生物学及其对人类健康影响的整体理解。随着我们在这一领域知识的不断进步，对抗病毒感染的斗争将变得越来越复杂，为全球患者改善结果铺平道路。