tacrine

简明释义

英[ˈtækriːn]美[tækˈraɪn]

n. 他克林（用于治疗轻中度老年痴呆症的药物）

英英释义

单词用法

同义词

反义词

例句

1.Aim to synthesize acylated prodrug of tacrine hydrochloride (THA) to improve the infiltration ability across the blood brain barrier (BBB).

目的制备盐酸他克林(THA)的酰化前体药物以提高其透过血脑屏障(BBB)的能力。

2.Aim to synthesize acylated prodrug of tacrine hydrochloride (THA) to improve the infiltration ability across the blood brain barrier (BBB).

目的制备盐酸他克林(THA)的酰化前体药物以提高其透过血脑屏障(BBB)的能力。

3.The doctor prescribed tacrine to help manage the symptoms of Alzheimer's disease.

医生开了他克林来帮助控制阿尔茨海默病的症状。

4.Patients taking tacrine need regular liver function tests.

服用他克林的患者需要定期进行肝功能检测。

5.After starting tacrine, the patient's memory showed noticeable improvement.

在开始服用他克林后，患者的记忆显著改善。

6.Research shows that tacrine can improve cognitive function in some patients.

研究表明，他克林可以改善一些患者的认知功能。

7.The side effects of tacrine may include nausea and diarrhea.

服用他克林的副作用可能包括恶心和腹泻。

作文

Tacrine, a drug that was once used in the treatment of Alzheimer's disease, represents an important chapter in the history of pharmacology. Introduced in the early 1990s, tacrine (他克林) was one of the first medications approved to help manage symptoms associated with this debilitating condition. The drug works by inhibiting the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. By preventing this breakdown, tacrine increases the levels of acetylcholine in the brain, thereby enhancing communication between nerve cells. This mechanism is crucial because Alzheimer’s disease is characterized by a decline in acetylcholine levels, leading to memory loss and cognitive decline.Despite its initial promise, the use of tacrine has been largely overshadowed by newer medications that offer similar benefits with fewer side effects. Patients taking tacrine often experienced gastrointestinal issues, liver toxicity, and other adverse reactions, which limited its appeal. As research progressed, it became clear that while tacrine could provide some symptomatic relief, it did not alter the underlying progression of Alzheimer's disease.The story of tacrine serves as a reminder of the complexities involved in developing effective treatments for neurodegenerative diseases. It highlights the importance of understanding both the pharmacological mechanisms and the potential side effects of any medication. In the years following tacrine's introduction, scientists have worked diligently to discover safer and more effective alternatives. Medications such as donepezil and rivastigmine have since become more popular, offering improved safety profiles and efficacy.Additionally, the journey of tacrine underscores the need for ongoing research in the field of neuroscience. Alzheimer's disease affects millions of individuals worldwide, and the search for effective treatments remains a top priority for researchers. The lessons learned from the development and eventual decline in the use of tacrine continue to inform current studies and clinical trials.In conclusion, tacrine may no longer be a frontline treatment for Alzheimer's disease, but its legacy endures in the annals of medical history. It paved the way for a better understanding of cholinergic therapies and the challenges faced in treating complex neurological conditions. As we move forward, the experiences gained from tacrine will undoubtedly contribute to future innovations in medicine, ultimately benefiting those affected by Alzheimer's and similar disorders.

他克林（tacrine）是一种曾用于治疗阿尔茨海默病的药物，代表了药理学历史中的一个重要篇章。它于1990年代初期推出，是第一批获得批准用于帮助管理这种衰弱性疾病相关症状的药物之一。这种药物通过抑制酶乙酰胆碱酯酶的作用来工作，该酶负责分解神经递质乙酰胆碱。通过防止这种分解，tacrine提高了大脑中乙酰胆碱的水平，从而增强神经细胞之间的沟通。这一机制至关重要，因为阿尔茨海默病的特征是乙酰胆碱水平的下降，导致记忆丧失和认知能力下降。尽管起初前景看好，但由于副作用较少的新药物出现，tacrine的使用在很大程度上被掩盖。服用tacrine的患者通常会经历胃肠问题、肝毒性和其他不良反应，这限制了其吸引力。随着研究的进展，越来越清楚的是，虽然tacrine可以提供一些症状缓解，但并不能改变阿尔茨海默病的根本进程。tacrine的故事提醒我们，在开发有效的神经退行性疾病治疗方法时所涉及的复杂性。它强调了理解药理机制和任何药物潜在副作用的重要性。在tacrine推出后的几年里，科学家们努力寻找更安全、更有效的替代品。像多奈哌齐和利伐斯的明等药物因此变得更受欢迎，提供了更好的安全性和疗效。此外，tacrine的历程突显了神经科学领域持续研究的必要性。阿尔茨海默病影响着全球数百万人，而寻找有效治疗方法仍然是研究人员的首要任务。从tacrine的开发和最终使用减少中获得的经验教训将继续为当前的研究和临床试验提供信息。总之，虽然tacrine可能不再是阿尔茨海默病的一线治疗药物，但它的遗产在医学历史中依然存在。它为我们更好地理解胆碱能治疗和治疗复杂神经系统疾病面临的挑战铺平了道路。随着我们向前迈进，从tacrine中获得的经验无疑将为未来的医学创新做出贡献，最终使受阿尔茨海默病和类似疾病影响的人受益。