polymyxin

简明释义

英[/ˌpɑːlɪˈmɪksɪn/]美[/ˌpɑːlɪˈmɪksɪn/]

n. [药][微] 多粘菌素

英英释义

单词用法

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例句

1.While most surveillance studies demonstrated high rates of susceptibility, several reports noted the emergence of polymyxin-resistant nosocomial pathogens.

很多监测研究证明的高敏感性，个别报告有医院获得性耐药株。

2.Conclusions Polymyxin was effective in the management of MDRP pulmonary infections in patient with avian influenza.

结论多黏菌素能有效治疗禽流感患者继发mdrp的感染。

3.Objective To observe the antimicrobial activity of immobilized polymyxin sulfate in vitro.

目的观察固定化硫酸多粘菌素体外抗微生物的效果。

4.Comparison on the effect of polymyxin B nonapeptide, lipid A structure antagonist, anti-LPS antibody and immune therapy, anti-endotoxin polypeptide and function of Chinese herb medicines on endotoxin.

分析了多粘菌素B九肽、类脂A结构拮抗剂、抗脂多糖抗体及免疫治疗、抗内毒素多肽以及中药对内毒素的作用。

5.Comparison on the effect of polymyxin B nonapeptide, lipid A structure antagonist, anti-LPS antibody and immune therapy, anti-endotoxin polypeptide and function of Chinese herb medicines on endotoxin.

分析了多粘菌素B九肽、类脂A结构拮抗剂、抗脂多糖抗体及免疫治疗、抗内毒素多肽以及中药对内毒素的作用。

6.Researchers are studying the effectiveness of polymyxin 多粘菌素 against antibiotic-resistant bacteria.

研究人员正在研究多粘菌素对抗生素耐药细菌的有效性。

7.The side effects of polymyxin 多粘菌素 can include nephrotoxicity and neurotoxicity.

使用多粘菌素的副作用可能包括肾毒性和神经毒性。

8.The use of polymyxin 多粘菌素 in clinical settings has increased due to rising resistance rates.

由于抗药性上升，多粘菌素在临床环境中的使用增加了。

9.In cases of multidrug-resistant infections, polymyxin 多粘菌素 may be one of the few treatment options available.

在多重耐药感染的情况下，多粘菌素可能是为数不多的可用治疗选择之一。

10.The doctor prescribed polymyxin 多粘菌素 to treat the patient's severe infection.

医生开了多粘菌素来治疗患者的严重感染。

作文

Polymyxins are a class of antibiotics that have been widely used to treat infections caused by Gram-negative bacteria. These antibiotics, particularly polymyxin B and colistin, have gained attention due to their effectiveness against multidrug-resistant strains of bacteria. The rise in antibiotic resistance has led to a resurgence in the use of polymyxin, which was once considered a last-resort treatment. Understanding how polymyxin works is essential for healthcare professionals, especially in the face of increasing bacterial resistance.The mechanism of action of polymyxin involves disrupting the bacterial cell membrane. By binding to the lipopolysaccharide molecules in the outer membrane of Gram-negative bacteria, polymyxin alters the permeability of the membrane, leading to cell death. This unique mechanism makes polymyxin effective against bacteria that are resistant to other classes of antibiotics. However, its use is not without risks; nephrotoxicity and neurotoxicity are significant concerns when administering polymyxin, particularly in patients with pre-existing conditions.As the medical community faces the challenge of antibiotic resistance, the role of polymyxin becomes increasingly important. Studies have shown that combination therapy, using polymyxin alongside other antibiotics, can enhance efficacy and reduce toxicity. This approach allows for a more comprehensive treatment strategy against resistant infections while minimizing the adverse effects associated with high doses of polymyxin alone.In addition to its clinical applications, research on polymyxin has also expanded into understanding its environmental impact. As these antibiotics are used in agriculture, they can enter the ecosystem, potentially contributing to the development of resistant bacterial strains in the environment. This raises concerns about the long-term sustainability of using polymyxin and similar antibiotics in both human medicine and veterinary practices.The future of polymyxin usage will likely involve careful consideration of its benefits and risks. As new alternatives are developed, including novel antibiotics and bacteriophage therapy, polymyxin may be used more selectively. Education and awareness among healthcare providers about the appropriate use of polymyxin are crucial to preserving its effectiveness and preventing further resistance.In conclusion, polymyxin represents a vital tool in our antibiotic arsenal, particularly against resistant Gram-negative infections. Its unique mechanism of action and ability to target difficult pathogens make it invaluable in modern medicine. However, the potential for toxicity and environmental impact necessitates cautious use and ongoing research. By understanding and respecting the power of polymyxin, we can better navigate the challenges posed by antibiotic resistance and ensure effective treatment options for future generations.

多粘菌素是一类广泛用于治疗由革兰氏阴性细菌引起的感染的抗生素。这些抗生素，特别是多粘菌素B和胶质菌素，由于其对多重耐药菌株的有效性而受到关注。抗生素耐药性的上升使得多粘菌素的使用重新受到重视，这种药物曾被认为是最后的治疗手段。理解多粘菌素的作用机制对于医疗专业人士尤其重要，特别是在细菌耐药性日益增加的情况下。多粘菌素的作用机制涉及破坏细菌的细胞膜。通过与革兰氏阴性细菌外膜中的脂多糖分子结合，多粘菌素改变了膜的通透性，从而导致细胞死亡。这一独特的机制使得多粘菌素对其他类别抗生素耐药的细菌有效。然而，其使用并非没有风险；肾毒性和神经毒性在给药时是显著的担忧，尤其是在有既往病史的患者中。随着医学界面临抗生素耐药性的挑战，多粘菌素的角色变得愈加重要。研究表明，使用多粘菌素与其他抗生素联合治疗可以增强疗效并减少毒性。这种方法允许更全面的治疗策略来应对耐药性感染，同时最小化单独高剂量使用多粘菌素所带来的不良反应。除了临床应用外，对多粘菌素的研究也扩展到理解其环境影响。由于这些抗生素在农业中的使用，它们可能进入生态系统，潜在地导致环境中耐药细菌株的发展。这引发了对在人体医学和兽医实践中使用多粘菌素和类似抗生素的长期可持续性的担忧。多粘菌素使用的未来可能会涉及对其益处和风险的仔细考虑。随着新替代品的开发，包括新型抗生素和噬菌体疗法，多粘菌素的使用可能会更加选择性。提高医疗提供者对适当使用多粘菌素的认识和教育对于保护其有效性和防止进一步耐药至关重要。总之，多粘菌素代表了我们抗生素武器库中的一个重要工具，尤其是在对抗耐药的革兰氏阴性感染方面。其独特的作用机制和针对难治病原体的能力使其在现代医学中不可或缺。然而，潜在的毒性和环境影响要求谨慎使用和持续研究。通过理解和尊重多粘菌素的力量，我们可以更好地应对抗生素耐药性带来的挑战，并确保未来几代人有效的治疗选择。