teratogenicity

简明释义

英[terətəʊdʒɪˈnɪsəti]美[ˌterətdʒəˈnɪsəti]

n. 致畸性；畸形形成性

英英释义

单词用法

同义词

反义词

例句

1.Say, read the book you see smoke on the fetal well, easy to teratogenicity.

就说你看到书上写着抽烟对胎儿不好，容易致畸。

2.Objective: To study the time-effect relationship of mice embryonic toxicity and teratogenicity induced by HCHO in vitro.

目的：探讨甲醛对植入后小鼠胚胎发育毒性及时间-效应关系。

3.Objective To study the teratogenicity and subacute toxicity of chlorine dioxide for its safety assessment.

目的研究二氧化氯消毒液的致畸性和亚急性毒性。

4.Opuntia milpa alta flower has no maternal toxicity, embryonic and teratogenicity under the experimental conditions.

在本实验剂量和条件下仙人掌粉未见有母体毒性、胚胎毒性和致畸作用。

5.OBJECTIVE to explore the toxicological effects of Slug capsule on teratogenicity and mutagenicity.

目的探讨蛞蝓胶囊是否具有致畸和致突变的毒理作用。

6.Objective To observe reproductive toxicity and teratogenicity of compound medlar oral solution in rats by intragastric administration.

目的观察复方枸杞子口服液经灌胃对大鼠的生殖毒性和胚胎致畸作用。

7.Standard toxicological assessments indicate no significant acute or chronic toxicity from PC, as well as no mutagenicity and no teratogenicity.

常规的毒理学试验没有发现PC有显著的长期或急性毒性，同时也没有发现PC具有致突变和致畸作用。

8.It is Colorless tasteless, non-toxic, non-stimulated, no residue, no resistance and no teratogenicity.

无色无味、无毒、无刺激、无残留、无耐药性、无致畸性；可入口入眼。

9.Researchers are investigating the teratogenicity of various chemicals in cosmetics.

研究人员正在调查化妆品中各种化学物质的致畸性。

10.Understanding the teratogenicity of environmental toxins is crucial for public health.

了解环境毒素的致畸性对公共健康至关重要。

11.Animal studies can provide insights into the teratogenicity of new drugs.

动物研究可以提供有关新药物的致畸性的见解。

12.The teratogenicity of alcohol consumption during pregnancy can lead to fetal alcohol syndrome.

怀孕期间饮酒的致畸性可能导致胎儿酒精综合症。

13.The study focused on the teratogenicity of certain medications during pregnancy.

这项研究集中于某些药物在怀孕期间的致畸性。

作文

Teratogenicity is a term used to describe the capability of a substance to cause malformation or abnormal development in a developing embryo or fetus. This concept is crucial in the fields of pharmacology, toxicology, and maternal-fetal medicine, as it helps researchers and healthcare professionals understand the risks associated with various drugs, chemicals, and environmental factors during pregnancy. The implications of teratogenicity (致畸性) are profound, as they can affect not only the health of the unborn child but also the well-being of the mother and family. One of the most well-known examples of teratogenic effects is the drug thalidomide, which was prescribed in the late 1950s and early 1960s to alleviate morning sickness in pregnant women. Unfortunately, it was later discovered that thalidomide had severe teratogenicity (致畸性), leading to thousands of babies being born with limb deformities and other serious health issues. This tragic episode highlighted the importance of rigorous testing for teratogenic effects before a drug is approved for use in pregnant women. In addition to pharmaceuticals, various environmental factors can also exhibit teratogenicity (致畸性). For instance, exposure to certain chemicals, such as heavy metals or pesticides, during pregnancy has been linked to developmental disorders in children. Alcohol consumption during pregnancy is another significant risk factor, leading to fetal alcohol spectrum disorders (FASDs), which encompass a range of physical, behavioral, and learning problems. These examples underscore the necessity for public health initiatives aimed at educating expectant mothers about potential teratogens in their environment. The study of teratogenicity (致畸性) involves various methodologies, including animal studies, epidemiological research, and in vitro experiments. Researchers often use animal models to assess the potential risks of substances on fetal development. For example, scientists may administer a compound to pregnant animals and observe any resulting abnormalities in the offspring. This data can then inform human risk assessments, although it is essential to remember that results from animal studies do not always directly translate to humans due to differences in physiology. Epidemiological studies also play a vital role in understanding teratogenicity (致畸性). By examining large populations of pregnant women and their children, researchers can identify patterns and correlations between exposure to specific substances and the incidence of birth defects. These studies can provide valuable insights into the safety of various drugs and environmental exposures during pregnancy. Furthermore, advancements in genetic research have opened new avenues for exploring teratogenicity (致畸性). Scientists are now investigating how genetic predispositions may interact with environmental factors to influence fetal development. This research could lead to more personalized approaches in assessing teratogenic risks, ultimately improving maternal and fetal health outcomes. In conclusion, understanding teratogenicity (致畸性) is essential for safeguarding the health of both mothers and their children. It requires a multidisciplinary approach involving pharmacology, toxicology, epidemiology, and genetics. By continuing to study and raise awareness about the risks associated with teratogenic substances, we can work towards ensuring healthier pregnancies and reducing the incidence of birth defects. As we advance our knowledge in this field, it is crucial for healthcare providers to communicate effectively with patients about potential risks and for regulatory agencies to enforce stringent safety measures regarding substances that may pose teratogenic threats.

致畸性是一个用于描述某种物质导致发育中的胚胎或胎儿发生畸形或异常发育能力的术语。这个概念在药理学、毒理学和母胎医学领域至关重要，因为它帮助研究人员和医疗专业人员理解怀孕期间各种药物、化学物质和环境因素的风险。致畸性的影响深远，因为它不仅可能影响未出生孩子的健康，还可能影响母亲和家庭的幸福。最著名的致畸效应例子之一是药物沙利度胺，它在1950年代末和1960年代初被开给孕妇以缓解晨吐。不幸的是，后来发现沙利度胺具有严重的致畸性，导致数千名婴儿出生时四肢畸形和其他严重健康问题。这一悲惨事件突显了在药物获准用于孕妇之前进行严格测试以评估其致畸效应的重要性。除了药物，许多环境因素也可能表现出致畸性。例如，在怀孕期间接触某些化学物质，如重金属或农药，已与儿童发育障碍有关。怀孕期间饮酒是另一个重要的风险因素，导致胎儿酒精谱系障碍（FASD），这包括一系列身体、行为和学习问题。这些例子强调了公共卫生倡议的必要性，旨在教育准妈妈们了解潜在的环境致畸因子。对致畸性的研究涉及多种方法，包括动物研究、流行病学研究和体外实验。研究人员通常使用动物模型来评估物质对胎儿发育的潜在风险。例如，科学家可能会将一种化合物施用给怀孕的动物，并观察后代是否出现任何异常。这些数据可以为人类风险评估提供信息，尽管需要记住的是，动物研究的结果并不总是能直接转化为人类，因为生理差异。流行病学研究在理解致畸性方面也发挥着重要作用。通过检查大量孕妇及其子女，研究人员可以识别暴露于特定物质与出生缺陷发生率之间的模式和关联。这些研究能够提供关于怀孕期间各种药物和环境暴露安全性的宝贵见解。此外，遗传研究的进展为探索致畸性开辟了新的途径。科学家们现在正在研究遗传易感性如何与环境因素相互作用，从而影响胎儿发育。这项研究可能导致更个性化的评估致畸风险的方法，最终改善母婴健康结果。总之，理解致畸性对于保护母亲和孩子的健康至关重要。它需要药理学、毒理学、流行病学和遗传学等多学科的综合方法。通过继续研究并提高对致畸物质相关风险的认识，我们可以努力确保更健康的妊娠，减少出生缺陷的发生率。随着我们在这一领域知识的不断进步，医疗服务提供者与患者之间有效沟通潜在风险，以及监管机构对可能构成致畸威胁的物质实施严格安全措施，都是至关重要的。