methotrexate

简明释义

英[ˌmeθəʊˈtrekseɪt]美[ˌmeθəˈtrekseɪt]

n. 甲氨蝶呤，[药] 氨甲叶酸，[药] 氨甲蝶呤

英英释义

单词用法

同义词

反义词

例句

1.You should be particularly cautious about drinking alcohol if you take methotrexate.

如果你服用甲氨蝶呤的话，还得对饮酒格外小心。

2.Objective: To establish the in vitro release method of the sustained-release implant of methotrexate.

目的：建立甲氨蝶呤缓释植入剂体外释放方法。

3.Objective To discuss the practicability of high-dose methotrexate (HD-MTX) in treatment of acute lymphoblastic leukemia (ALL) in children in basic-level hospitals.

目的探讨大剂量甲氨蝶呤(HD -MTX)治疗急性淋巴细胞白血病(all)在基层医院的可行性。

4.This is important, as people prescribed methotrexate are often advised to limit their alcohol intake to avoid possible liver problems.

这点很重要，因为根据规定，甲氨蝶呤服用过程中要限制酒精的摄入以避免可能引起的肝脏损伤。

5.Objective To observe the effect of methotrexate injection through intubation by hysteroscopy.

目的观察宫腔镜插管注入氨甲蝶呤治疗输卵管妊娠的疗效。

6.Objective To study the clinic features and the mechanism of skin damage induced by high-dose methotrexate (HD-MTX).

目的了解大剂量氨甲蝶呤(HD - MTX)化疗引起皮肤损伤的临床特征，并探讨其发生机制。

7.Conclusion High performance capillary zone electrophoresis is a simple, rapid, and economic method for the chiral resolution of methotrexate.

结论高效毛细管区带电泳法拆分氨甲蝶呤手性对映体简单、快速、经济。

8.Intraspinal commonly used drug methotrexate and cytarabine.

椎管内常用的药物有甲氨喋呤及阿糖胞苷。

9.The doctor prescribed methotrexate for the patient's rheumatoid arthritis.

医生为患者的类风湿关节炎开了甲氨蝶呤。

10.In some cases, methotrexate is used to treat certain types of cancer.

在某些情况下，甲氨蝶呤用于治疗某些类型的癌症。

11.Before starting methotrexate, the patient was informed about potential risks.

在开始使用甲氨蝶呤之前，患者被告知潜在风险。

12.Side effects of methotrexate may include nausea and fatigue.

使用甲氨蝶呤的副作用可能包括恶心和疲劳。

13.Patients taking methotrexate should have regular blood tests to monitor liver function.

服用甲氨蝶呤的患者应定期进行血液检查以监测肝功能。

作文

Methotrexate is a medication that has been widely used in the treatment of various medical conditions, particularly in oncology and rheumatology. It is classified as an antimetabolite and works by inhibiting the metabolism of folic acid, which is essential for the synthesis of DNA and RNA. This mechanism makes methotrexate an effective drug for treating certain types of cancer, such as leukemia and lymphoma, as well as autoimmune diseases like rheumatoid arthritis and psoriasis.The history of methotrexate dates back to the 1940s when it was initially developed as a chemotherapy agent. Its ability to interfere with cellular reproduction made it a crucial component in cancer treatment protocols. Over the years, research has shown that methotrexate can also be beneficial in lower doses for non-cancerous conditions. For instance, patients suffering from rheumatoid arthritis often experience significant relief from joint pain and inflammation when treated with this drug.Despite its effectiveness, the use of methotrexate is not without risks. Common side effects include nausea, fatigue, and increased susceptibility to infections due to its immunosuppressive properties. More serious complications can arise, such as liver damage and lung toxicity, especially when used at high doses or for extended periods. Therefore, patients receiving methotrexate must be closely monitored by their healthcare providers to manage any potential adverse effects.One of the critical aspects of methotrexate therapy is the importance of adherence to prescribed dosages and schedules. Patients are often advised to take the medication once a week rather than daily, which can help minimize side effects while still providing therapeutic benefits. Additionally, folic acid supplements are frequently recommended to mitigate some of the side effects associated with methotrexate.Furthermore, ongoing research continues to explore the full potential of methotrexate in various clinical settings. Studies are investigating its use in combination with other therapies to enhance efficacy and reduce resistance in cancer treatment. Additionally, researchers are looking into its role in treating other conditions, such as inflammatory bowel disease and certain skin disorders, expanding the horizons of this versatile drug.In conclusion, methotrexate is a powerful medication that plays a vital role in modern medicine, particularly in oncology and rheumatology. While it offers significant benefits in treating various diseases, its potential side effects necessitate careful management and monitoring. As our understanding of methotrexate continues to evolve, it remains an essential tool in the fight against cancer and autoimmune diseases, highlighting the importance of ongoing research and patient education in maximizing its benefits while minimizing risks.

甲氨蝶呤是一种广泛用于治疗各种医疗条件的药物，特别是在肿瘤学和风湿病学中。它被归类为抗代谢药物，通过抑制叶酸的代谢来发挥作用，而叶酸是合成DNA和RNA所必需的。这一机制使得甲氨蝶呤成为治疗某些类型癌症（如白血病和淋巴瘤）以及自身免疫性疾病（如类风湿关节炎和银屑病）的有效药物。甲氨蝶呤的历史可以追溯到20世纪40年代，当时它最初被开发为化疗药物。它干扰细胞繁殖的能力使其成为癌症治疗方案中的关键组成部分。多年来，研究表明，甲氨蝶呤在较低剂量下也可以对非癌症状况有益。例如，患有类风湿关节炎的患者在接受这种药物治疗时，通常会显著缓解关节疼痛和炎症。尽管效果显著，使用甲氨蝶呤并非没有风险。常见的副作用包括恶心、疲劳和由于其免疫抑制特性而导致的感染易感性增加。更严重的并发症可能出现，例如肝损伤和肺毒性，尤其是在高剂量或长期使用时。因此，接受甲氨蝶呤治疗的患者必须由医疗提供者密切监测，以管理任何潜在的不良反应。甲氨蝶呤治疗的一个关键方面是遵循处方剂量和时间表的重要性。患者通常被建议每周服用一次该药物，而不是每天服用，这有助于最小化副作用，同时仍提供治疗益处。此外，通常建议补充叶酸，以减轻与甲氨蝶呤相关的一些副作用。此外，持续的研究继续探索甲氨蝶呤在各种临床环境中的全部潜力。研究正在调查其与其他疗法联合使用以增强疗效和减少癌症治疗中的耐药性。此外，研究人员还在研究其在治疗其他疾病（如炎症性肠病和某些皮肤疾病）中的作用，扩大了这种多功能药物的视野。总之，甲氨蝶呤是一种强效药物，在现代医学中发挥着重要作用，特别是在肿瘤学和风湿病学中。虽然它在治疗各种疾病方面提供了显著的益处，但其潜在的副作用需要仔细管理和监测。随着我们对甲氨蝶呤的理解不断发展，它仍然是抗击癌症和自身免疫性疾病的重要工具，突显了持续研究和患者教育在最大化其益处同时最小化风险中的重要性。