anaplerotic

简明释义

英[ˌænəpləˈrɑtɪk]美[ˌænəpləˈrɑtɪk]

补缺的

英英释义

单词用法

同义词

反义词

例句

1.In cells with high PHGDH expression, the serine synthesis pathway contributes approximately 50% of the total anaplerotic flux of glutamine into the TCA cycle.

在PHGDH高表达的细胞中，丝氨酸合成途径为三羧酸循环贡献了接近总量50%的谷氨酰胺回补通量。

2.In cells with high PHGDH expression, the serine synthesis pathway contributes approximately 50% of the total anaplerotic flux of glutamine into the TCA cycle.

在PHGDH高表达的细胞中，丝氨酸合成途径为三羧酸循环贡献了接近总量50%的谷氨酰胺回补通量。

3.In the liver, certain amino acids can act as Anaplerotic 补充代谢物 to support energy metabolism.

在肝脏中，某些氨基酸可以作为Anaplerotic 补充代谢物来支持能量代谢。

4.Certain dietary components can enhance Anaplerotic 补充代谢作用 in athletes, improving their performance.

某些膳食成分可以增强运动员的Anaplerotic 补充代谢作用，提高他们的表现。

5.The study found that succinate acts as an Anaplerotic 补充代谢物 in the heart during ischemia.

研究发现，在缺血状态下，琥珀酸在心脏中充当Anaplerotic 补充代谢物。

6.Fatty acid oxidation is considered an Anaplerotic 补充代谢反应 that contributes to the regeneration of TCA cycle intermediates.

脂肪酸氧化被认为是一种Anaplerotic 补充代谢反应，有助于TCA循环中间体的再生。

7.The process of gluconeogenesis serves as an important Anaplerotic 补充代谢途径 that replenishes citric acid cycle intermediates.

糖异生过程作为一个重要的Anaplerotic 补充代谢途径，补充了柠檬酸循环的中间体。

作文

The term anaplerotic refers to metabolic pathways that replenish intermediates in the citric acid cycle (CAC), which is crucial for cellular respiration and energy production. Understanding the role of anaplerotic reactions is essential for biochemists and physiologists, as they play a significant role in maintaining the balance of metabolites necessary for optimal cellular function. In essence, anaplerotic processes help to ensure that the cycle does not run out of key components, allowing it to continue functioning effectively.One of the most well-known anaplerotic reactions involves the conversion of pyruvate to oxaloacetate by the enzyme pyruvate carboxylase. This reaction is particularly important during periods of high energy demand, such as intense exercise or fasting, when the levels of certain intermediates may be depleted. By replenishing these intermediates, anaplerotic pathways enable the citric acid cycle to produce ATP efficiently, which is vital for sustaining cellular activities.Moreover, the significance of anaplerotic reactions extends beyond energy metabolism. They also play a critical role in amino acid biosynthesis and the synthesis of various biomolecules. For instance, the replenishment of α-ketoglutarate through anaplerotic pathways can facilitate the synthesis of glutamate, an important neurotransmitter in the brain. This connection highlights the intricate relationship between metabolism and neurological function, showcasing how anaplerotic reactions are intertwined with the overall health of an organism.In addition to their physiological relevance, anaplerotic reactions have gained attention in the context of disease. Alterations in anaplerotic metabolism can contribute to various pathologies, including cancer, where tumor cells often exhibit altered metabolic profiles. Many cancer cells rely heavily on anaplerotic pathways to support their rapid growth and proliferation. By understanding these mechanisms, researchers are exploring potential therapeutic strategies that target anaplerotic metabolism in cancer treatment, aiming to disrupt the metabolic flexibility that allows tumors to thrive.Furthermore, nutritional factors can influence anaplerotic processes. Certain diets rich in specific nutrients can enhance the efficiency of anaplerotic reactions, thereby supporting metabolic health. For example, diets high in carbohydrates can provide ample pyruvate for anaplerotic reactions, ensuring the citric acid cycle remains adequately supplied with intermediates. Conversely, deficiencies in key vitamins or minerals can impair these pathways, leading to metabolic dysfunction and associated health issues.In conclusion, the understanding of anaplerotic pathways is crucial for comprehending how cells maintain metabolic balance and energy production. These reactions not only support the citric acid cycle but also have far-reaching implications for overall health, disease, and nutrition. As research continues to unravel the complexities of metabolic pathways, the importance of anaplerotic processes will undoubtedly become more pronounced, emphasizing their role in both normal physiology and pathological conditions.

“anaplerotic”一词指的是补充三羧酸循环（CAC）中中间体的代谢途径，这对细胞呼吸和能量生产至关重要。理解anaplerotic反应的作用对于生物化学家和生理学家来说是必要的，因为它们在维持细胞功能所需的代谢物平衡方面发挥着重要作用。从本质上讲，anaplerotic过程有助于确保循环不会缺少关键成分，从而使其能够有效地继续运作。最著名的anaplerotic反应之一是通过丙酮酸羧化酶将丙酮酸转化为草酰乙酸。这个反应在高能需求期间尤为重要，例如剧烈运动或禁食时，当某些中间体的水平可能被耗尽。通过补充这些中间体，anaplerotic途径使三羧酸循环能够有效地产生ATP，这对于维持细胞活动至关重要。此外，anaplerotic反应的重要性不仅限于能量代谢。它们在氨基酸生物合成和各种生物分子的合成中也起着关键作用。例如，通过anaplerotic途径补充α-酮戊二酸可以促进谷氨酸的合成，而谷氨酸是大脑中一种重要的神经递质。这种联系突显了代谢与神经功能之间的复杂关系，展示了anaplerotic反应如何与生物体的整体健康交织在一起。除了生理相关性外，anaplerotic反应在疾病背景下也引起了关注。anaplerotic代谢的改变可能导致各种病理状况，包括癌症，其中肿瘤细胞通常表现出改变的代谢特征。许多癌细胞严重依赖anaplerotic途径来支持其快速生长和增殖。通过了解这些机制，研究人员正在探索针对癌症治疗中anaplerotic代谢的潜在治疗策略，旨在破坏允许肿瘤生存的代谢灵活性。此外，营养因素可以影响anaplerotic过程。某些富含特定营养素的饮食可以增强anaplerotic反应的效率，从而支持代谢健康。例如，富含碳水化合物的饮食可以为anaplerotic反应提供充足的丙酮酸，确保三羧酸循环保持适当的中间体供应。相反，关键维生素或矿物质的缺乏可能会损害这些途径，导致代谢功能障碍及相关健康问题。总之，理解anaplerotic途径对理解细胞如何维持代谢平衡和能量生产至关重要。这些反应不仅支持三羧酸循环，还有着深远的健康、疾病和营养影响。随着研究继续揭示代谢途径的复杂性，anaplerotic过程的重要性无疑会变得更加突出，强调其在正常生理和病理条件中的作用。