antiestrogen

简明释义

英[ˌæn.tiˈɛs.trə.dʒən]美[ˌæn.tiˈɛs.trə.dʒən]

n. [药] 抗雌激素（一种能抑制雌激素的产生、活动及作用的物质）

英英释义

单词用法

同义词

反义词

例句

1.The estrogen receptor modulator drugs launched or developed in recent years were reviewed, mainly including selective estrogen receptor modulators and pure antiestrogen.

综述近几年上市或开发中的雌激素受体调节剂类药物，主要包括选择性雌激素受体调节剂和纯抗雌激素药物。

2.The research advances on the antiestrogen compounds and their structure-activity relationships are reviewed.

本文重点综述近年来抗雌激素化合物的作用机制、构效关系及其研究进展。

3.The objective response to antiestrogen tamoxifen (TAM)in advanced breast cancer with respect to its estrogen receptor (ER) Status was studied in 55 patients.

在55例晚期乳癌病人中研究了抗雌激素他莫昔芬（TAM）治疗效果和乳癌雌激素受体（ER）状态的关系。

4.The estrogen receptor modulator drugs launched or developed in recent years were reviewed, mainly including selective estrogen receptor modulators and pure antiestrogen.

综述近几年上市或开发中的雌激素受体调节剂类药物，主要包括选择性雌激素受体调节剂和纯抗雌激素药物。

5.The side effects of antiestrogens 抗雌激素 can include hot flashes and mood swings.

使用抗雌激素 antiestrogens的副作用可能包括潮热和情绪波动。

6.Tamoxifen is a well-known antiestrogen 抗雌激素 used in the treatment of breast cancer.

他莫昔芬是一种广为人知的抗雌激素 antiestrogen，用于乳腺癌的治疗。

7.Some fertility treatments involve using antiestrogens 抗雌激素 to stimulate ovulation.

一些生育治疗涉及使用抗雌激素 antiestrogens来刺激排卵。

8.Research shows that antiestrogens 抗雌激素 can reduce the risk of recurrence in certain types of breast tumors.

研究表明，抗雌激素 antiestrogens可以降低某些类型乳腺肿瘤复发的风险。

9.The doctor prescribed an antiestrogen 抗雌激素 to help manage her hormone-sensitive breast cancer.

医生开了一种抗雌激素 antiestrogen来帮助控制她的激素敏感型乳腺癌。

作文

In recent years, the field of medicine has made significant advancements in understanding various hormonal therapies. One such area that has gained attention is the use of antiestrogen (抗雌激素) treatments, particularly in the management of hormone-sensitive cancers such as breast cancer. Antiestrogens are compounds that inhibit the effects of estrogen in the body, and they play a crucial role in the treatment protocols for patients diagnosed with these types of cancers.Estrogen is a hormone that can promote the growth of certain types of cancer cells. In breast cancer, for instance, some tumors have receptors that respond to estrogen, leading to accelerated growth and spread of the disease. This is where antiestrogen therapies become vital. By blocking estrogen from binding to its receptors, these treatments can slow down or even stop the progression of cancer.There are several types of antiestrogen medications available, including selective estrogen receptor modulators (SERMs) and aromatase inhibitors. SERMs, such as tamoxifen, work by binding to estrogen receptors on cancer cells, effectively preventing estrogen from exerting its effects. On the other hand, aromatase inhibitors, like anastrozole, reduce the overall levels of estrogen in the body by inhibiting the enzyme aromatase, which converts androgens into estrogens.The choice between using SERMs or aromatase inhibitors often depends on the specific characteristics of the cancer and the patient's overall health. For premenopausal women, tamoxifen is commonly prescribed, while postmenopausal women may benefit more from aromatase inhibitors. Both classes of antiestrogen drugs have been shown to significantly improve survival rates and reduce the risk of cancer recurrence.However, the use of antiestrogen therapies is not without side effects. Patients may experience symptoms such as hot flashes, mood swings, and vaginal dryness. Additionally, long-term use of some antiestrogen medications can lead to an increased risk of other health issues, such as blood clots or endometrial cancer. Therefore, it is essential for healthcare providers to monitor patients closely and adjust treatment plans as necessary.Research into antiestrogen therapies continues to evolve, with scientists exploring new compounds and treatment regimens that could enhance efficacy and minimize side effects. Clinical trials are ongoing to determine the best combinations of antiestrogen drugs with other therapies, such as chemotherapy or targeted therapies, to create a more comprehensive treatment approach.In conclusion, antiestrogen treatments represent a pivotal advancement in oncology, particularly for patients with hormone-sensitive cancers. By understanding how these therapies work and their potential benefits and risks, both patients and healthcare providers can make informed decisions about cancer treatment. As research progresses, the hope is that antiestrogen therapies will become even more effective, offering better outcomes and improved quality of life for those affected by hormone-related cancers.

近年来，医学领域在理解各种激素疗法方面取得了显著进展。其中一个备受关注的领域是使用抗雌激素（抗雌激素）治疗，特别是在管理激素敏感性癌症（如乳腺癌）方面。抗雌激素是一种抑制体内雌激素作用的化合物，它们在治疗这些类型癌症的患者中发挥着至关重要的作用。雌激素是一种可以促进某些类型癌细胞生长的激素。例如，在乳腺癌中，一些肿瘤具有对雌激素反应的受体，导致疾病的加速生长和扩散。这就是抗雌激素疗法变得至关重要的地方。通过阻止雌激素与其受体结合，这些治疗可以减缓甚至停止癌症的进展。目前有几种类型的抗雌激素药物，包括选择性雌激素受体调节剂（SERM）和芳香化酶抑制剂。SERM，如他莫昔芬，通过与癌细胞上的雌激素受体结合，有效地防止雌激素发挥其作用。另一方面，芳香化酶抑制剂，如阿那曲唑，通过抑制芳香化酶这一将雄激素转化为雌激素的酶，降低体内雌激素的总体水平。选择使用SERM还是芳香化酶抑制剂通常取决于癌症的具体特征和患者的整体健康状况。对于绝经前女性，通常会开处他莫昔芬，而绝经后女性可能更能从芳香化酶抑制剂中受益。这两类抗雌激素药物已被证明显著提高生存率并降低癌症复发的风险。然而，使用抗雌激素疗法并非没有副作用。患者可能会经历潮热、情绪波动和阴道干涩等症状。此外，某些抗雌激素药物的长期使用可能会导致其他健康问题的风险增加，例如血栓或子宫内膜癌。因此，医疗提供者密切监测患者并根据需要调整治疗方案至关重要。对抗雌激素疗法的研究持续发展，科学家们正在探索新的化合物和治疗方案，以增强疗效并最小化副作用。临床试验正在进行中，以确定最佳的抗雌激素药物与其他疗法（如化疗或靶向疗法）的组合，以创建更全面的治疗方法。总之，抗雌激素治疗代表了肿瘤学中的一个重要进展，特别是对于患有激素相关癌症的患者。通过理解这些疗法的工作原理及其潜在的益处和风险，患者和医疗提供者都可以就癌症治疗做出明智的决定。随着研究的进展，希望抗雌激素疗法能够变得更加有效，为那些受到激素相关癌症影响的人提供更好的结果和更高的生活质量。