neuraminidase

简明释义

英[ˌnjʊərəˈmɪnɪdeɪz]美[ˌnʊrəˈmɪnɪˌdes;ˌnʊrəˈmɪnɪˌde

n. [生化] 神经氨酸苷酶，[生化] 唾液酸苷酶

英英释义

单词用法

同义词

反义词

例句

1.METHODS a series of pyrrolidine derivatives were synthesized from L-hydroxyproline, and the neuraminidase inhibitory activities of these compounds were tested using high throughput screening.

方法以L -羟脯氨酸为原料，合成一系列神经氨酸酶抑制剂，并用高通量活性筛选方法检测其对神经氨酸酶的抑制活性。

2.Neuraminidase (NA) is an important protein on the surface of virion and plays an important role in immune and lethality.

神经氨酸酶（NA）是流感病毒表面的一种重要蛋白质，在免疫和致病方面起重要作用。

3.The virus strain was identified Avian Influenza virus a, the sub-serotypes of hemagglutinin (ha) and neuraminidase (NA) were not determined. And the strain had excellent immunogenicity.

经血清学鉴定为A型禽流感病毒(HA、NA亚型未测定)，该病毒株具有良好的免疫原性。

4.After the virus infects the cells of the respiratory system and begins replicating, neuraminidase cuts the newly formed copies free to invade other cells.

呼吸系统内的细胞染上病毒，而且病毒开始复制之后，神经氨酸酵素会将新生的病毒切下以便侵犯其他细胞。

5.Objective: to select the peptide binding to influenza virus neuraminidase from phage display 12 peptide library.

目的：从噬菌体呈现12肽库中筛选与流感病毒神经氨酸酶特异性结合的肽。

6.Zanamivir and oseltamivir bind differently at the neuraminidase catalytic site and this contributes to different drug resistance profiles.

扎那米韦和奥塞·米韦结合在神经氨酸酶的不同催化位点，这就导致了这种耐药情况不同的发生。

7.METHODS a series of pyrrolidine derivatives were synthesized from L-hydroxyproline, and the neuraminidase inhibitory activities of these compounds were tested using high throughput screening.

方法以L -羟脯氨酸为原料，合成一系列神经氨酸酶抑制剂，并用高通量活性筛选方法检测其对神经氨酸酶的抑制活性。

8.The result show that, neuraminidase is one of the main immune protective antigen for the Hps, which provides a theoretical basis for further study of the Hps subunit vaccine.

结果表明神经氨酸酶是Hps的主要免疫保护性抗原之一，为进一步研究Hps亚单位疫苗提供理论依据。

9.The H5N1 virus is expected to be susceptible to the neuraminidase inhibitors.

H5N1病毒预期对神经氨酸酶抑制剂敏感。

10.The structure of neuraminidase is crucial for developing effective vaccines against influenza.

神经氨酸酶的结构对于开发有效的流感疫苗至关重要。

11.Inhibition of neuraminidase can lead to a reduction in viral replication.

抑制神经氨酸酶可以导致病毒复制的减少。

12.Researchers are studying the role of neuraminidase in the pathogenicity of certain strains of bacteria.

研究人员正在研究神经氨酸酶在某些细菌株致病性中的作用。

13.The influenza virus uses neuraminidase to help release new viral particles from infected cells.

流感病毒利用神经氨酸酶帮助释放感染细胞中的新病毒颗粒。

14.Antiviral medications like oseltamivir target neuraminidase to inhibit the spread of the flu virus.

像奥司他韦这样的抗病毒药物针对神经氨酸酶以抑制流感病毒的传播。

作文

The study of viruses has revealed many fascinating aspects of their biology, particularly the mechanisms they use to infect host cells. One critical enzyme involved in this process is neuraminidase, which plays a vital role in the life cycle of influenza viruses. Understanding neuraminidase is essential for developing effective antiviral drugs and vaccines, as it directly influences the spread of the virus within the host. Neuraminidase is an enzyme that catalyzes the hydrolysis of sialic acid residues from glycoproteins and glycolipids on the surface of host cells. This action is crucial during the viral replication cycle because it facilitates the release of newly formed viral particles from infected cells. Without the activity of neuraminidase, the virus would remain attached to the cell membrane, preventing the spread of infection to neighboring cells. Therefore, neuraminidase is a target for antiviral drugs, such as oseltamivir (Tamiflu) and zanamivir (Relenza), which inhibit its function and help control the severity and duration of influenza infections.In addition to its role in viral replication, neuraminidase is also involved in the immune response to influenza. When the virus infects a host, it triggers an immune response that aims to eliminate the virus. The presence of neuraminidase on the viral surface can influence how effectively the immune system recognizes and responds to the virus. Some studies suggest that variations in neuraminidase may affect the virulence of different influenza strains, leading to more severe outbreaks in certain populations.Moreover, the genetic variability of neuraminidase contributes to the challenges faced in vaccine development. Influenza viruses are known for their ability to mutate rapidly, which can result in changes to the structure of neuraminidase. These mutations can lead to the emergence of new viral strains that may escape recognition by the immune system, rendering existing vaccines less effective. Thus, continuous monitoring of neuraminidase and other viral components is necessary to ensure that vaccines remain effective against circulating strains.In conclusion, neuraminidase is a crucial enzyme in the biology of influenza viruses, influencing both viral replication and the host's immune response. Its role as a target for antiviral therapies highlights its importance in managing influenza outbreaks. As researchers continue to study neuraminidase and its variants, we gain valuable insights that could lead to improved strategies for combating influenza and potentially other viral infections. The ongoing exploration of neuraminidase not only enhances our understanding of viral pathogenesis but also paves the way for advancements in public health and disease prevention strategies.

病毒的研究揭示了它们生物学的许多迷人方面，特别是它们用来感染宿主细胞的机制。一个关键的酶在这个过程中发挥着重要作用，那就是神经氨酸酶，它在流感病毒的生命周期中扮演着至关重要的角色。理解神经氨酸酶对于开发有效的抗病毒药物和疫苗至关重要，因为它直接影响病毒在宿主内的传播。神经氨酸酶是一种催化宿主细胞表面糖蛋白和糖脂上唾液酸残基水解的酶。这一作用在病毒复制周期中至关重要，因为它促进新形成的病毒颗粒从感染的细胞中释放出来。如果没有神经氨酸酶的活性，病毒将会附着在细胞膜上，阻止感染传播到邻近的细胞。因此，神经氨酸酶成为抗病毒药物的目标，如奥司他韦（Tamiflu）和扎那米韦（Relenza），这些药物抑制其功能，帮助控制流感感染的严重程度和持续时间。除了在病毒复制中的作用外，神经氨酸酶还参与流感的免疫反应。当病毒感染宿主时，它会触发一种旨在消除病毒的免疫反应。病毒表面存在的神经氨酸酶可能会影响免疫系统识别和应对病毒的有效性。一些研究表明，神经氨酸酶的变异可能影响不同流感株的毒力，导致某些人群中更严重的疫情爆发。此外，神经氨酸酶的遗传变异性给疫苗开发带来了挑战。流感病毒以其快速突变的能力而闻名，这可能导致神经氨酸酶结构的变化。这些突变可能导致新病毒株的出现，从而逃避免疫系统的识别，使现有疫苗的效果降低。因此，持续监测神经氨酸酶和其他病毒成分是必要的，以确保疫苗对流行株保持有效。总之，神经氨酸酶是在流感病毒生物学中至关重要的酶，影响病毒复制和宿主的免疫反应。它作为抗病毒治疗的目标，突显了其在管理流感疫情中的重要性。随着研究人员继续研究神经氨酸酶及其变体，我们获得了宝贵的见解，这可能导致改善对抗流感和潜在其他病毒感染的策略。对神经氨酸酶的持续探索不仅增强了我们对病毒致病机制的理解，还为公共卫生和疾病预防策略的进步铺平了道路。