oxalacetate

简明释义

英[ˌɑksəˈlæsəˌteɪt]美[ˌɑksəˈlæsəˌteɪt]

草乙酸盐

英英释义

单词用法

同义词

反义词

例句

1.This paper reports the improvement on the synthesis of 5 methylisoxazol 3 formamide by Claisen condensation of diethyl oxalacetate followed by cyclization and ammonolysis.

讨论了以草酸二乙酯为原料，经过克莱森缩合、环合、氨解反应合成5甲基异唑3甲酰胺工艺的改进。

2.This paper reports the improvement on the synthesis of 5 methylisoxazol 3 formamide by Claisen condensation of diethyl oxalacetate followed by cyclization and ammonolysis.

讨论了以草酸二乙酯为原料，经过克莱森缩合、环合、氨解反应合成5甲基异唑3甲酰胺工艺的改进。

3.The concentration of oxalacetate can affect the rate of cellular respiration.

草酰乙酸的浓度可以影响细胞呼吸的速度。

4.Researchers are studying the role of oxalacetate in metabolic disorders.

研究人员正在研究草酰乙酸在代谢紊乱中的作用。

5.During gluconeogenesis, oxalacetate is converted into phosphoenolpyruvate.

在糖异生过程中，草酰乙酸被转化为磷酸烯醇丙酮酸。

6.In the Krebs cycle, oxalacetate is crucial for the regeneration of citric acid.

在克雷布斯循环中，草酰乙酸对柠檬酸的再生至关重要。

7.A deficiency in oxalacetate can lead to energy production issues in cells.

草酰乙酸的缺乏可能导致细胞能量生产问题。

作文

In the realm of biochemistry, understanding metabolic pathways is crucial for comprehending how living organisms function at a molecular level. One important molecule in these pathways is oxalacetate, which plays a significant role in the Krebs cycle, also known as the citric acid cycle. This cycle is essential for cellular respiration, where cells convert nutrients into energy. Oxalacetate is a four-carbon dicarboxylic acid that acts as a key intermediate in this cycle. It is formed from the reaction of acetyl-CoA and oxaloacetate, catalyzed by the enzyme citrate synthase. The presence of oxalacetate is vital because it combines with acetyl-CoA to form citrate, initiating the series of reactions that ultimately lead to the production of ATP, the energy currency of the cell.Moreover, oxalacetate is not only involved in the Krebs cycle but also plays a role in gluconeogenesis, the process by which glucose is synthesized from non-carbohydrate sources. This is particularly important during fasting or intense exercise when the body needs to maintain blood glucose levels. In gluconeogenesis, oxalacetate is converted to phosphoenolpyruvate (PEP) by the enzyme PEP carboxykinase. This step is critical as it helps regulate blood sugar levels and provides energy substrates for various tissues.The importance of oxalacetate extends beyond energy production; it also participates in amino acid synthesis. For instance, oxalacetate can be transaminated to form aspartate, an amino acid that is a building block for proteins. This illustrates the interconnectedness of metabolic pathways, where one molecule can serve multiple functions within the cell.In addition to its biological significance, abnormalities in oxalacetate metabolism can lead to various health issues. For example, excessive accumulation of oxalate, a derivative of oxalacetate, can result in kidney stones and other renal complications. Understanding the role of oxalacetate in these processes is crucial for developing therapeutic strategies to address such conditions.In conclusion, oxalacetate is a multifaceted molecule that plays a pivotal role in energy metabolism, gluconeogenesis, and amino acid synthesis. Its involvement in the Krebs cycle highlights its importance in cellular respiration, while its role in gluconeogenesis underscores its significance in maintaining glucose homeostasis. Furthermore, the implications of oxalacetate in health and disease make it a vital subject of study in biochemistry and medicine. By deepening our understanding of oxalacetate and its functions, we can better appreciate the intricate biochemical networks that sustain life and potentially uncover new avenues for medical intervention.

在生物化学的领域中，理解代谢途径对于理解生物体在分子水平上的功能至关重要。一个在这些途径中重要的分子是草酰乙酸，它在克雷布斯循环中发挥着重要作用，也被称为柠檬酸循环。这个循环对细胞呼吸至关重要，细胞将营养物质转化为能量。草酰乙酸是一种四碳二羧酸，在这个循环中作为关键中间体。它是由乙酰辅酶A和草酰乙酸反应形成的，该反应由柠檬酸合成酶催化。草酰乙酸的存在至关重要，因为它与乙酰辅酶A结合形成柠檬酸，启动一系列反应，最终导致ATP的产生，ATP是细胞的能量货币。此外，草酰乙酸不仅参与克雷布斯循环，还在糖异生中发挥作用，这个过程是指从非碳水化合物来源合成葡萄糖。这在禁食或剧烈运动期间尤为重要，此时身体需要维持血糖水平。在糖异生中，草酰乙酸通过酶PEP羧激酶转化为磷酸烯醇丙酮酸（PEP）。这一步骤至关重要，因为它有助于调节血糖水平，并为各种组织提供能量底物。草酰乙酸的重要性不仅体现在能量生产上，它还参与氨基酸的合成。例如，草酰乙酸可以通过转氨基化反应形成天冬氨酸，这是一种蛋白质的构建块。这说明了代谢途径之间的相互联系，一个分子可以在细胞内发挥多重功能。除了其生物学意义外，草酰乙酸代谢异常可能导致各种健康问题。例如，草酰乙酸的过度积累会导致肾结石和其他肾脏并发症。理解草酰乙酸在这些过程中的作用对于开发治疗策略以解决此类情况至关重要。总之，草酰乙酸是一种多面分子，在能量代谢、糖异生和氨基酸合成中发挥着关键作用。它在克雷布斯循环中的参与突显了它在细胞呼吸中的重要性，而它在糖异生中的作用则强调了它在维持葡萄糖稳态中的重要性。此外，草酰乙酸在健康和疾病中的影响使其成为生物化学和医学研究的重要课题。通过加深对草酰乙酸及其功能的理解，我们可以更好地欣赏维持生命的复杂生化网络，并可能发现新的医学干预途径。