spironolactone

简明释义

英[ˌspaɪrənəʊˈlæktəʊn]美[spaɪˈrɑːnəˈlækˌtoʊn]

n. [药] 安体舒通；螺内酯；螺旋内酯甾酮（一种利尿药）

英英释义

单词用法

同义词

反义词

例句

1.Aim to evaluate the effects of aldosterone (ald) and spironolactone (spi, one of the aldosterone receptor antagonists) on proliferation and cell cycle phase of cultured rat mesangial cells in vitro.

目的研究醛固酮(ald)及其受体拮抗剂螺内酯(SPI)对大鼠肾小球系膜细胞增殖和细胞周期的影响。

2.Background: Add-on spironolactone therapy substantially improves clinical outcomes among patients with severe heart failure (HF) on standard therapy.

背景：接受标准治疗的重度心力衰竭(HF)患者加用螺内酯可以明显改善其临床预后。

3.The advent of spironolactone laid the anticancer drug in China's leading position in the international arena.

安体舒的问世，奠定了我国抗肿瘤药物在国际上的领先地位。

4.Spironolactone (Aldactone) is a diuretic that can help ease some of the symptoms of PMS.

安体舒通(阿尔达克通)就是一种利尿剂，可帮助缓解PMS的一些症状。

5.Objective: to observe the effects of spironolactone on right ventricular myocardial collagen in rats chronically exposed to hypoxia hypercapnia and to investigate the significance of aldosterone.

观察安体舒通对慢性低氧高二氧化碳大鼠右心室肌间质胶原的影响，探讨醛固酮在心肌间质增生中的意义。

6.At a mean follow-up of slightly more than 5 years, 3 losartan patients and 22 spironolactone patients had developed type 2 diabetes.

平均随访5年以上，三名应用洛沙坦的患者以及22名应用螺内酯的患者出现了二型糖尿病。

7.The first involves the use of the drugs lisinopril, carvedilol, spironolactone, and losartan to enhance reverse remodelling.

第一个阶段包括药物赖诺普利，卡维地洛、螺内酯和洛沙坦的应用，以提高逆转重塑。

8.The first involves the use of the drugs lisinopril carvedilol spironolactone and losartan to enhance reverse remodel ling.

第一个阶段包括药物赖诺普利，卡维地洛、螺内酯和洛沙坦的应用，以提高逆转重塑。

9.He was advised to avoid potassium-rich foods while on spironolactone.

他被建议在服用螺内酯期间避免富含钾的食物。

10.The doctor prescribed spironolactone for her high blood pressure.

医生为她的高血压开了螺内酯。

11.Patients taking spironolactone should have their potassium levels monitored regularly.

服用螺内酯的患者应定期监测钾水平。

12.The side effects of spironolactone can include dizziness and fatigue.

服用螺内酯的副作用可能包括头晕和疲劳。

13.After starting spironolactone, she noticed a decrease in swelling.

开始服用螺内酯后，她注意到肿胀减轻了。

作文

Spironolactone is a medication that plays a vital role in the treatment of various medical conditions, particularly those related to the heart and kidneys. It is classified as a potassium-sparing diuretic, which means that it helps the body get rid of excess fluid while retaining potassium. This unique property makes spironolactone an essential drug for patients suffering from conditions such as heart failure, high blood pressure, and certain types of edema. The mechanism of action of spironolactone involves blocking the effects of aldosterone, a hormone that can cause the body to retain sodium and water. By inhibiting this hormone, spironolactone promotes the excretion of sodium and water, leading to a decrease in blood volume and, consequently, lower blood pressure.In addition to its use in managing heart-related issues, spironolactone has also gained recognition for its effectiveness in treating hormonal imbalances. For instance, it is often prescribed for women with polycystic ovary syndrome (PCOS), a condition characterized by irregular menstrual cycles and excessive hair growth. In such cases, spironolactone helps to reduce androgen levels, thereby alleviating symptoms associated with this hormonal disorder.The versatility of spironolactone extends beyond just diuretic effects. It is also used in the management of acne and other skin conditions due to its ability to regulate hormonal activity. Many dermatologists prescribe spironolactone off-label for treating acne in women, as it can effectively reduce oil production and improve skin texture.Despite its numerous benefits, spironolactone is not without potential side effects. Patients taking this medication may experience dizziness, fatigue, or gastrointestinal disturbances. Additionally, because it is a potassium-sparing diuretic, there is a risk of hyperkalemia, a condition characterized by elevated potassium levels in the blood. Therefore, regular monitoring of potassium levels is essential for individuals on spironolactone therapy.It is crucial for patients to have open discussions with their healthcare providers about the risks and benefits of spironolactone. This ensures that they are well-informed about how the medication works and what to expect during treatment. Furthermore, lifestyle modifications, such as maintaining a balanced diet and staying hydrated, can enhance the effectiveness of spironolactone while minimizing potential side effects.In conclusion, spironolactone is a multifaceted medication that serves various purposes in modern medicine. Its ability to manage fluid retention, lower blood pressure, and address hormonal imbalances makes it a valuable tool for healthcare professionals. As research continues to explore the full range of benefits associated with spironolactone, it remains important for patients to engage actively in their treatment plans, ensuring that they receive the best possible care. Understanding the role of spironolactone in their health journey empowers patients to make informed decisions and fosters a collaborative relationship with their healthcare team.

螺内酯是一种在治疗各种医疗条件中发挥重要作用的药物，特别是与心脏和肾脏相关的疾病。它被归类为保钾利尿剂，这意味着它有助于身体排除多余的液体，同时保留钾。这种独特的特性使得螺内酯成为患有心力衰竭、高血压和某些类型水肿的患者的重要药物。螺内酯的作用机制涉及阻断醛固酮的作用，醛固酮是一种可能导致身体保留钠和水的激素。通过抑制这种激素，螺内酯促进钠和水的排泄，从而降低血容量，并因此降低血压。除了用于管理与心脏相关的问题外，螺内酯还因其在治疗激素失衡方面的有效性而受到认可。例如，它通常被开给患有多囊卵巢综合症（PCOS）的女性，这是一种以月经周期不规律和多毛症为特征的疾病。在这种情况下，螺内酯有助于降低雄激素水平，从而缓解与这种激素紊乱相关的症状。螺内酯的多功能性不仅限于利尿作用。由于其调节激素活动的能力，它也被用于管理痤疮和其他皮肤病。许多皮肤科医生会为女性开具螺内酯以治疗痤疮，因为它可以有效减少油脂分泌并改善皮肤质地。尽管有许多好处，螺内酯并非没有潜在的副作用。服用此药物的患者可能会经历头晕、疲劳或胃肠不适。此外，由于它是一种保钾利尿剂，存在高钾血症的风险，这是一种以血液中钾水平升高为特征的疾病。因此，定期监测血钾水平对使用螺内酯治疗的个体至关重要。患者与医疗服务提供者之间进行开放讨论关于螺内酯的风险和收益至关重要。这确保他们充分了解药物的作用及治疗期间的预期。此外，保持均衡饮食和保持水分等生活方式的调整可以增强螺内酯的效果，同时最小化潜在的副作用。总之，螺内酯是一种多面向的药物，在现代医学中发挥着多种作用。它管理液体潴留、降低血压和解决激素失衡的能力使其成为医疗专业人员的一项宝贵工具。随着研究继续探索与螺内酯相关的全部益处，患者主动参与其治疗计划仍然很重要，以确保他们获得最佳护理。理解螺内酯在健康旅程中的作用使患者能够做出明智的决定，并促进与医疗团队的合作关系。