propositus

简明释义

英[prəˈpɒzɪtəs]美[proˈpɑzətəs]

n. 先证者；祖先；直接受影响之人

复 数 p r o p o s i t i

英英释义

单词用法

同义词

反义词

例句

1.By PCR-SSCP analysis, 17 PCR products were identified with different mobility of single strand DNA in propositus. 9 suspectable mutations were revealed with DNA sequencing analysis.

SSCP分析发现17个外显子pcr产物单链dna迁移率异常，通过DNA直接测序发现9个外显子可疑突变，但反向测序均未能证实。

2.By PCR-SSCP analysis, 17 PCR products were identified with different mobility of single strand DNA in propositus. 9 suspectable mutations were revealed with DNA sequencing analysis.

SSCP分析发现17个外显子pcr产物单链dna迁移率异常，通过DNA直接测序发现9个外显子可疑突变，但反向测序均未能证实。

3.The propositus was a healthy Han ethnic newborn female.

先证者为一健康汉族女性新生儿。

4.The propositus was a young man of Li ethnic group, belonging to heterozygote.

先证者为黎族男青年，属杂合子。

5.The case study focused on the propositus and their immediate family members.

案例研究集中在被提议者及其直系亲属身上。

6.The scientist presented a study on the genetic traits of the propositus.

科学家展示了一项关于被提议者遗传特征的研究。

7.During the meeting, we discussed the implications of the findings related to the propositus.

在会议期间，我们讨论了与被提议者相关的发现的影响。

8.In this family tree, the propositus is marked to show the starting point of the research.

在这个家谱中，被提议者被标记以显示研究的起点。

9.The doctor examined the propositus to gather more information about the hereditary disease.

医生检查了被提议者以收集更多关于遗传疾病的信息。

作文

In the realm of genetics and family studies, the term propositus refers to an individual who is the subject of a genetic study or pedigree analysis. This term is vital for understanding hereditary conditions and tracking genetic traits through generations. The propositus serves as the starting point from which researchers can trace lineage and determine how certain traits are passed down. For instance, if a particular genetic disorder is identified in a family, the propositus would be the first person in that family to be studied in-depth to understand the inheritance pattern.When conducting a genetic study, identifying the propositus is crucial because they provide a clear point of reference. Researchers often gather detailed medical histories, perform genetic testing, and analyze family trees to see how the condition has manifested in relatives. This process helps in determining whether the trait is dominant, recessive, or linked to sex chromosomes. Moreover, the information gathered from the propositus can be used to inform other family members about their risks of inheriting similar traits or conditions.The significance of the propositus extends beyond just genetic research; it also plays a role in counseling and prevention strategies. By understanding the genetic background of the propositus, healthcare professionals can offer tailored advice to family members, potentially leading to early interventions or lifestyle changes that might mitigate the effects of hereditary conditions. For example, if the propositus is found to carry a gene associated with a high risk of breast cancer, other female relatives may be advised to undergo regular screenings or consider preventive measures.Furthermore, the concept of the propositus highlights the importance of familial connections in genetics. Each propositus is not merely an isolated case but part of a larger family narrative that reflects shared genetic heritage. This interconnectedness can be particularly poignant in cultures that place a strong emphasis on family lineage and ancestry. Understanding the propositus allows families to appreciate their genetic history and its implications for future generations.In conclusion, the term propositus is more than just a technical term in genetics; it embodies the intricate relationship between individuals and their families. By studying the propositus, researchers can unlock valuable insights into genetic disorders, paving the way for better health outcomes and informed decision-making. As we continue to explore the complexities of human genetics, the role of the propositus will remain central to our understanding of heredity and its impact on health and well-being.

在遗传学和家族研究的领域中，术语propositus指的是在遗传研究或谱系分析中作为研究对象的个体。这个术语对于理解遗传性疾病和追踪代际遗传特征至关重要。propositus是研究者追踪血统和确定某些特征如何传递的起点。例如，如果在一个家庭中发现了特定的遗传疾病，propositus将是第一个被深入研究的人，以了解遗传模式。在进行遗传研究时，识别propositus至关重要，因为它们提供了一个明确的参考点。研究人员通常会收集详细的病史，进行基因检测，并分析家谱，以查看该病症在亲属中的表现。这一过程有助于确定特征是显性、隐性还是与性染色体相关。此外，从propositus那里获得的信息可以用于告知其他家庭成员他们继承类似特征或疾病的风险。propositus的重要性不仅仅局限于遗传研究；它在咨询和预防策略中也发挥着作用。通过了解propositus的遗传背景，医疗专业人员可以为家庭成员提供量身定制的建议，从而可能导致早期干预或生活方式的改变，以减轻遗传疾病的影响。例如，如果发现propositus携带与乳腺癌高风险相关的基因，其他女性亲属可能会被建议进行定期筛查或考虑预防措施。此外，propositus的概念突显了遗传学中家庭联系的重要性。每个propositus不仅仅是一个孤立的案例，而是反映共享遗传遗产的更大家庭叙事的一部分。这种相互联系在强调家庭血统和祖先的文化中尤为深刻。理解propositus使家庭能够欣赏他们的遗传历史及其对未来几代人的影响。总之，术语propositus不仅仅是遗传学中的一个技术术语；它体现了个体与家庭之间错综复杂的关系。通过研究propositus，研究人员可以揭示有关遗传疾病的宝贵见解，为更好的健康结果和知情决策铺平道路。随着我们继续探索人类遗传学的复杂性，propositus的角色将在我们理解遗传及其对健康和福祉的影响中保持核心地位。