bisphosphonates

简明释义

英[bɪsˈfɒsfəneɪts]美[bɪsˈfɑsfəˌneɪts]

二膦酸盐

英英释义

单词用法

同义词

反义词

例句

1.Oral bisphosphonates have become a mainstay of treatment, but concerns have emerged that long-term use of these drugs may suppress bone remodeling, leading to unusual fractures.

口服双磷酸盐类药物是治疗该病的主要方法，但长期使用这些药物可能会抑制骨重塑，从而导致罕见的骨折，其使用风险令人担忧。

2.She picked the drugs because of studies in humans that suggest bisphosphonates may help prevent cancer from spreading to the bone.

她之所以选择这些药物是因为在人类研究中表明双磷酸盐可以帮助阻止癌症扩散到骨骼。

3.Researchers studied women taking these medications – called bisphosphonates – who experienced some sort of fracture.

研究人员研究服用骨松药物- 成分为双磷酸盐 - 的妇女，这些妇女都经历过某种骨骼断裂。

4.Bisphosphonates is recommended for patients with bone metastases which can reduce the incidence of bone-related events.

伴有肾癌骨转移患者，推荐应用双膦酸盐药物，以减少骨相关事件的发生。

5.Context: Bisphosphonates have been widely used in the treatment of osteoporosis.

研究背景：双磷酸盐在骨质疏松中被广泛应用。

6.Tell your dentist if you take bisphosphonates.

如果你在使用这种药，去联系你的牙医吧。

7.Patients taking bisphosphonates should be aware of potential side effects, such as gastrointestinal issues.

服用二膦酸盐的患者应注意潜在的副作用，例如胃肠问题。

8.Patients should take bisphosphonates on an empty stomach to improve absorption.

患者应在空腹时服用二膦酸盐以提高吸收效果。

9.Long-term use of bisphosphonates may lead to rare but serious complications, including osteonecrosis of the jaw.

长期使用二膦酸盐可能导致罕见但严重的并发症，包括下颌骨坏死。

10.Doctors often prescribe bisphosphonates to help prevent bone loss in patients with osteoporosis.

医生通常会开处方二膦酸盐以帮助预防骨质疏松症患者的骨骼流失。

11.Research indicates that bisphosphonates can reduce the risk of fractures in postmenopausal women.

研究表明，二膦酸盐可以降低绝经后女性骨折的风险。

作文

Bisphosphonates are a class of medications that play a crucial role in the treatment of various bone disorders. These drugs are primarily used to prevent and treat osteoporosis, a condition characterized by weak and brittle bones. Osteoporosis is particularly common among postmenopausal women, but it can also affect men and individuals with certain medical conditions. The mechanism of action of bisphosphonates (双膦酸盐) involves inhibiting the activity of osteoclasts, the cells responsible for bone resorption. By doing so, bisphosphonates (双膦酸盐) help to maintain or increase bone density, thereby reducing the risk of fractures.One of the most significant advantages of bisphosphonates (双膦酸盐) is their ability to significantly decrease the incidence of hip and vertebral fractures in patients with osteoporosis. Clinical studies have demonstrated that patients who take these medications regularly experience fewer fractures compared to those who do not. This is particularly important as fractures can lead to severe complications, including loss of mobility and independence, which can drastically affect a person's quality of life.In addition to osteoporosis, bisphosphonates (双膦酸盐) are also used in the treatment of other bone-related diseases, such as Paget's disease and bone metastases from cancers. In patients with Paget's disease, the abnormal remodeling of bone can lead to pain and deformity, and bisphosphonates (双膦酸盐) can help normalize this process. For cancer patients, these medications can alleviate bone pain and reduce the risk of skeletal-related events, such as fractures and the need for radiation therapy.However, it is essential to be aware of the potential side effects associated with bisphosphonates (双膦酸盐). Some patients may experience gastrointestinal issues, such as nausea or abdominal pain. More serious but rare side effects include osteonecrosis of the jaw, particularly in patients receiving high doses for cancer treatment. Therefore, it is crucial for healthcare providers to assess the risks and benefits of bisphosphonates (双膦酸盐) before prescribing them.The administration of bisphosphonates (双膦酸盐) can vary; they are available in oral forms as well as intravenous formulations. Oral bisphosphonates (双膦酸盐) must be taken on an empty stomach, and patients are advised to remain upright for at least 30 minutes afterward to minimize the risk of esophageal irritation. On the other hand, intravenous bisphosphonates (双膦酸盐) are typically given in a clinical setting and can provide more immediate effects, especially in patients who may have difficulty swallowing pills.In conclusion, bisphosphonates (双膦酸盐) represent a vital therapeutic option for individuals suffering from various bone disorders. Their ability to enhance bone density and reduce fracture risk makes them an essential component of osteoporosis management. As research continues to advance, the understanding of bisphosphonates (双膦酸盐) will likely expand, leading to improved treatment protocols and outcomes for patients. It is imperative for patients to engage in discussions with their healthcare providers to determine the most appropriate treatment plan tailored to their specific needs.

双膦酸盐是一类在治疗各种骨骼疾病中发挥重要作用的药物。这些药物主要用于预防和治疗骨质疏松症，这是一种以骨骼脆弱和易碎为特征的疾病。骨质疏松症在绝经后女性中尤其常见，但也可能影响男性和某些医疗条件下的个体。双膦酸盐的作用机制是抑制破骨细胞的活性，破骨细胞是负责骨吸收的细胞。通过这样做，双膦酸盐有助于维持或增加骨密度，从而降低骨折的风险。双膦酸盐的一个显著优势是能够显著降低骨质疏松症患者的髋关节和椎骨骨折发生率。临床研究表明，定期服用这些药物的患者与不服用者相比，骨折发生率较低。这一点尤为重要，因为骨折可能导致严重的并发症，包括失去行动能力和独立性，这会极大地影响个人的生活质量。除了骨质疏松症，双膦酸盐还用于治疗其他与骨骼相关的疾病，如佩吉特病和癌症引起的骨转移。在佩吉特病患者中，骨骼的异常重塑可能导致疼痛和畸形，而双膦酸盐可以帮助正常化这一过程。对于癌症患者，这些药物可以缓解骨痛，并减少骨骼相关事件的风险，如骨折和放疗的需要。然而，了解与双膦酸盐相关的潜在副作用也至关重要。一些患者可能会经历胃肠问题，如恶心或腹痛。更严重但罕见的副作用包括颌骨坏死，尤其是在接受高剂量癌症治疗的患者中。因此，医疗提供者在开处方之前评估双膦酸盐的风险和收益至关重要。双膦酸盐的给药方式可以有所不同；它们有口服形式和静脉注射制剂。口服双膦酸盐必须在空腹时服用，建议患者在服药后保持直立至少30分钟，以减少食管刺激的风险。另一方面，静脉注射的双膦酸盐通常在临床环境中给予，可以在患者可能难以吞咽药片时提供更即时的效果。总之，双膦酸盐代表了对患有各种骨骼疾病的个体的重要治疗选择。它们增强骨密度和降低骨折风险的能力使其成为骨质疏松症管理的关键组成部分。随着研究的持续推进，对双膦酸盐的理解可能会扩展，从而改善治疗方案和患者的结果。患者与医疗提供者进行讨论，以确定最适合其特定需求的治疗计划，是至关重要的。