pentamidine

简明释义

英[penˈtæmɪˌdiːn]美[penˈtæməˌdin]

n. [药] 戊烷脒

英英释义

单词用法

同义词

反义词

例句

1.The disease is endemic to Africa; two geographically isolated strains are known. Treatment for this disease includes using suramin or pentamidine; both are fairly toxic.

这种疾病在非洲区域有两种锥虫为患，通常用苏拉明或喷他脒来治疗，两者都具有相当的毒性。

2.The disease is endemic to Africa; two geographically isolated strains are known. Treatment for this disease includes using suramin or pentamidine; both are fairly toxic.

这种疾病在非洲区域有两种锥虫为患，通常用苏拉明或喷他脒来治疗，两者都具有相当的毒性。

3.Patients receiving pentamidine should be monitored for potential side effects.

接受潘托米定治疗的患者应监测潜在的副作用。

4.The administration of pentamidine can be done via inhalation or intravenous injection.

可以通过吸入或静脉注射来给药潘托米定。

5.Healthcare providers need to educate patients about the use of pentamidine and its potential risks.

医疗提供者需要教育患者关于潘托米定的使用及其潜在风险。

6.In clinical trials, pentamidine showed effectiveness against certain fungal infections.

在临床试验中，潘托米定对某些真菌感染显示出有效性。

7.The doctor prescribed pentamidine for the treatment of pneumonia caused by Pneumocystis jirovecii.

医生开了潘托米定用于治疗由肺囊虫引起的肺炎。

作文

Pentamidine is a medication that has been used for several decades to treat various parasitic infections, particularly those caused by the protozoan parasite known as Trypanosoma brucei, which is responsible for African sleeping sickness. This disease can be fatal if not treated promptly, making the role of pentamidine crucial in public health, especially in endemic regions of Africa. The use of pentamidine has evolved over the years, and it is now also utilized in the treatment of Pneumocystis pneumonia, a common opportunistic infection in individuals with weakened immune systems, such as those living with HIV/AIDS.The mechanism of action of pentamidine involves interference with the parasite's DNA and RNA synthesis, thereby inhibiting its growth and replication. While effective, pentamidine is not without side effects. Patients may experience adverse reactions including hypotension, hypoglycemia, and renal toxicity. Therefore, monitoring during treatment is essential to mitigate these risks. Despite its potential dangers, the benefits of pentamidine in saving lives from serious infections cannot be overstated.In clinical settings, healthcare providers must weigh the risks and benefits of using pentamidine. For example, in cases of African sleeping sickness, the choice of therapy may depend on the stage of the disease and the patient's overall health. While there are alternative treatments available, pentamidine remains an important option, particularly when other medications are ineffective or contraindicated.Moreover, the availability of pentamidine can vary significantly across different regions. In some areas, access to this medication is limited due to logistical challenges, regulatory issues, or economic constraints. This disparity highlights the need for global health initiatives focused on improving access to essential medications like pentamidine, especially in low-resource settings where infectious diseases are prevalent.Research continues to explore new formulations and delivery methods for pentamidine to enhance its efficacy and reduce side effects. Innovations in drug delivery systems, such as liposomal formulations, aim to improve the therapeutic index of pentamidine while minimizing toxicity. As our understanding of pharmacology and parasitology advances, there is hope for even more effective treatments for diseases traditionally managed with pentamidine.In conclusion, pentamidine plays a vital role in the treatment of specific parasitic infections and remains a cornerstone in the fight against diseases like African sleeping sickness and Pneumocystis pneumonia. While challenges exist regarding its use and accessibility, ongoing research and public health efforts aim to ensure that this important medication remains available to those who need it most. As we continue to combat infectious diseases worldwide, the importance of pentamidine in our medical arsenal cannot be overlooked.

潘托米定是一种药物，几十年来用于治疗各种寄生虫感染，特别是由原生动物寄生虫引起的感染，这种寄生虫被称为锥虫（Trypanosoma brucei），它是导致非洲睡眠病的元凶。如果不及时治疗，这种疾病可能致命，因此pentamidine在公共卫生中的作用至关重要，尤其是在非洲的流行地区。pentamidine的使用随着时间的推移而发展，现在也用于治疗肺囊虫肺炎，这是一种常见的机会性感染，发生在免疫系统虚弱的个体中，比如那些感染HIV/AIDS的人。pentamidine的作用机制涉及干扰寄生虫的DNA和RNA合成，从而抑制其生长和复制。尽管有效，但pentamidine并非没有副作用。患者可能会经历不良反应，包括低血压、低血糖和肾毒性。因此，在治疗期间进行监测对于减轻这些风险至关重要。尽管存在潜在危险，但pentamidine在挽救严重感染生命方面的益处不可低估。在临床环境中，医疗提供者必须权衡使用pentamidine的风险和收益。例如，在非洲睡眠病的病例中，治疗选择可能取决于疾病的阶段和患者的整体健康状况。虽然有其他替代治疗可用，但pentamidine仍然是一个重要的选择，特别是在其他药物无效或禁忌的情况下。此外，pentamidine的可获得性在不同地区之间可能有显著差异。在某些地区，由于后勤挑战、监管问题或经济限制，该药物的获取受到限制。这种差距突显了全球卫生倡议的必要性，重点改善对像pentamidine这样基本药物的获取，特别是在寄生虫病流行的低资源环境中。研究仍在探索新的配方和给药方法，以增强pentamidine的疗效并减少副作用。药物输送系统的创新，例如脂质体配方，旨在提高pentamidine的治疗指数，同时最小化毒性。随着我们对药理学和寄生虫学的理解不断加深，人们对传统上用pentamidine管理的疾病有望获得更有效的治疗。总之，pentamidine在特定寄生虫感染的治疗中发挥着至关重要的作用，并且在对抗非洲睡眠病和肺囊虫肺炎等疾病的斗争中仍然是基石。尽管在使用和可及性方面存在挑战，但持续的研究和公共卫生努力旨在确保这种重要药物继续可供最需要的人使用。在我们继续与全球传染病作斗争的过程中，pentamidine在我们医疗武器库中的重要性不容忽视。