dicumarol

简明释义

英[/ˌdaɪ.kjuˈmɑː.rɒl/]美[/ˌdaɪ.kjuˈmɑː.rɒl/]

n. 双香豆素

英英释义

单词用法

同义词

反义词

例句

1.Warfarin a synthesized version of dicumarol is5to10times stronger than the original compound and is the most commonly used oral anticoagulant.

华法令是目前最常用的此类药物，它是一种合成的双香豆素类，比天然复合物强5-10倍。

2.Warfarin a synthesized version of dicumarol is5to10times stronger than the original compound and is the most commonly used oral anticoagulant.

华法令是目前最常用的此类药物，它是一种合成的双香豆素类，比天然复合物强5-10倍。

3.Warfarin, a synthesized version of dicumarol, is 5 to 10 times stronger than the original compound.

华法令是一种合成的双香豆素，比原始复合物强5到10倍。

4.After the surgery, the patient was advised to take dicumarol to reduce the risk of thrombosis.

手术后，病人被建议服用dicumarol以降低血栓的风险。

5.The effectiveness of dicumarol in anticoagulation therapy is well-documented.

dicumarol在抗凝治疗中的有效性是有充分记录的。

6.It is important to follow the dosage instructions when taking dicumarol.

服用dicumarol时遵循剂量说明是很重要的。

7.Patients on dicumarol need regular blood tests to monitor their INR levels.

服用dicumarol的病人需要定期进行血液检查以监测他们的INR水平。

8.The doctor prescribed dicumarol for the patient to prevent blood clots.

医生给病人开了dicumarol以防止血栓。

作文

Dicumarol is an anticoagulant that has played a significant role in the medical field since its discovery. Originally derived from spoiled sweet clover, it was first identified in the 1940s as a substance that could prevent blood clotting. This property makes dicumarol an essential medication for patients at risk of thrombosis, a condition where blood clots form inappropriately within blood vessels. The mechanism of action of dicumarol involves the inhibition of vitamin K epoxide reductase, an enzyme critical for the synthesis of certain clotting factors in the liver. By blocking this enzyme, dicumarol effectively reduces the levels of these factors, thereby decreasing the blood's ability to clot.The importance of dicumarol cannot be overstated, especially in the context of modern medicine. Patients who have undergone surgeries, particularly orthopedic procedures, or those suffering from conditions such as atrial fibrillation, often require anticoagulation therapy to minimize the risk of stroke or deep vein thrombosis. In such cases, dicumarol serves as a valuable tool in the management of these risks. However, it is crucial to monitor patients closely, as the therapeutic window for dicumarol is quite narrow; too little can lead to ineffective treatment, while too much can result in excessive bleeding.In addition to its clinical uses, the historical context of dicumarol is fascinating. Its discovery was somewhat serendipitous, arising from agricultural practices involving livestock. Farmers noticed that cattle consuming spoiled sweet clover were developing unusual bleeding disorders. This led researchers to investigate the compound responsible for this effect, ultimately leading to the identification of dicumarol and its anticoagulant properties. This story highlights the interconnectedness of agriculture and medicine, showcasing how natural substances can lead to significant medical advancements.Despite its benefits, dicumarol is not without risks and limitations. Patients on dicumarol therapy must adhere to strict dietary guidelines, particularly concerning vitamin K intake, as fluctuations in vitamin K levels can affect the efficacy of the drug. Additionally, there are potential interactions with other medications that can either potentiate or diminish the effects of dicumarol. Therefore, healthcare providers must conduct thorough assessments and provide comprehensive education to patients regarding their treatment.In conclusion, dicumarol is an important anticoagulant that has significantly impacted patient care, particularly in preventing thromboembolic events. Its unique origins and mechanism of action illustrate the importance of research and innovation in medicine. While it offers substantial benefits, careful management and monitoring are essential to ensure patient safety and therapeutic effectiveness. As we continue to advance our understanding of anticoagulants, dicumarol remains a vital part of the pharmacological landscape, reminding us of the delicate balance between treatment efficacy and safety.

双香豆素是一种抗凝剂，自发现以来在医学领域发挥了重要作用。最初来源于变质的甜苜蓿，它在20世纪40年代首次被确定为一种可以防止血液凝固的物质。这种特性使得双香豆素成为高风险血栓形成患者的重要药物，血栓形成是指血液在血管内不适当地形成血块。双香豆素的作用机制涉及对维生素K环氧化还原酶的抑制，这是一种在肝脏合成某些凝血因子所必需的酶。通过阻断这种酶，双香豆素有效降低这些因子的水平，从而减少血液的凝固能力。双香豆素的重要性不容小觑，特别是在现代医学的背景下。接受手术的患者，特别是骨科手术患者，或那些患有心房颤动等疾病的患者，通常需要抗凝治疗以降低中风或深静脉血栓的风险。在这种情况下，双香豆素作为管理这些风险的宝贵工具。然而，密切监测患者至关重要，因为双香豆素的治疗窗口相当狭窄；剂量过少可能导致治疗无效，而剂量过多则可能导致过度出血。除了临床用途外，双香豆素的历史背景也令人着迷。它的发现过程有些偶然，源于与牲畜的农业实践。农民注意到，食用变质甜苜蓿的牛出现了异常出血的疾病。这促使研究人员调查这种效应背后的化合物，最终确定了双香豆素及其抗凝特性。这个故事突显了农业和医学之间的相互联系，展示了天然物质如何导致重大的医学进步。尽管有其好处，双香豆素并非没有风险和局限性。接受双香豆素治疗的患者必须遵循严格的饮食指南，特别是关于维生素K的摄入，因为维生素K水平的波动会影响药物的有效性。此外，与其他药物的潜在相互作用可能会增强或减弱双香豆素的效果。因此，医疗提供者必须进行全面评估，并向患者提供有关其治疗的全面教育。总之，双香豆素是一种重要的抗凝剂，对患者护理产生了重大影响，特别是在预防血栓栓塞事件方面。它独特的起源和作用机制说明了研究和创新在医学中的重要性。虽然它提供了可观的益处，但谨慎管理和监测对于确保患者安全和治疗有效性至关重要。随着我们对抗凝剂理解的不断深入，双香豆素仍然是药理学领域的重要组成部分，提醒我们在治疗效果和安全性之间保持微妙的平衡。