conformational

简明释义

英[/kənˈfɔr.məˌneɪ.ʃən.əl/]美[/kənˈfɔr.məˌneɪ.ʃən.əl/]

adj. 构象的

英英释义

单词用法

同义词

反义词

例句

1.In the new conformational model, a small number of minor conformational sub-states that resemble the ligand-bound conformations are already present in solution.

少量类似于配体结合构象的次要构象亚态已在新的构象模型中进行了解析。

2.ObjectiveTo search for the conformational changes of proteins in subretinal fluid (SRF) in retinal detachment.

目的探讨视网膜脱离患者血清及视网膜下积液（SRF）蛋白质结构改变。

3.Presently, there is no catalogue of the multiple isoforms and epitopic and conformational variants of AFP in the literature.

当前文献中未见有AFP同工型和AFP表位及构象变体的分类。

4.Effects of perturbing various model parameters on the equilibriums between native-like states with other conformational states were considered.

我们考虑扰动不同力场参数对天然态和其它构象态之间平衡的影响。

5.We use a uniformly rotating dipole, which represent the inner freedom, to describe conformational changes.

用一个匀速转动的偶极子来描述马达的构象变化，考虑了马达的内部自由度。

6.Children who have outgrown their milk allergies, however, usually have milk-specific IgE antibodies directed against conformational epitopes.

虽然有些儿童长大而不再对牛奶过敏，然而，他们一般有牛奶过敏免疫球蛋白e抗体针对抗原构象表位。

7.The algorithm can be applied to molecules with large (several hundred) conformational models.

该算法可以应用于分子大（几百个）构模型。

8.In certain cases, conformational entropy appears to play a role in cooperative binding and enzyme catalysis.

在某些情况下，似乎象熵中发挥作用的合作具有约束力和酶催化。

9.The prodrug exposed to strong acid is protonated and undergoes a conformational change to its active form which is capable of inhibiting the proton pump.

前药的接触了强酸后被质子化，并且经过结构的改变成为真正能够抑制质子泵的活化形式。

10.The protein's conformational structure is crucial for its biological function.

蛋白质的构象结构对其生物功能至关重要。

11.Researchers are studying the conformational changes that occur during enzyme catalysis.

研究人员正在研究酶催化过程中发生的构象变化。

12.Molecular dynamics simulations help predict conformational changes over time.

分子动力学模拟有助于预测随时间变化的构象变化。

13.X-ray crystallography can reveal the conformational details of complex molecules.

X射线晶体学可以揭示复杂分子的构象细节。

14.The drug's efficacy may depend on its conformational flexibility.

药物的有效性可能取决于其构象灵活性。

作文

In the field of molecular biology and chemistry, the term conformational refers to the different shapes that a molecule can adopt due to rotation around single bonds. Understanding these conformational changes is crucial for comprehending how molecules interact with each other and how they perform their biological functions. For instance, proteins are made up of long chains of amino acids that can fold into various three-dimensional shapes. These shapes are not just random; they are determined by the conformational dynamics of the peptide bonds between the amino acids. When proteins fold into their functional structures, they achieve a specific conformational state that allows them to interact effectively with other molecules, such as substrates, inhibitors, or other proteins. If a protein does not fold correctly, it may lose its function, leading to diseases such as Alzheimer's or cystic fibrosis. Therefore, studying the conformational aspects of proteins can provide insights into their functions and the mechanisms of various diseases.Moreover, the concept of conformational changes is not limited to proteins. Nucleic acids, such as DNA and RNA, also undergo conformational transitions. For example, the double helix structure of DNA can unwind during replication and transcription, allowing the necessary enzymes to access the genetic information. The ability of DNA to change its conformational state is essential for cellular processes such as gene expression and regulation.In addition to biological molecules, the term conformational is also used in materials science. Polymers, which are large molecules composed of repeating structural units, can exhibit various conformational states based on temperature, pressure, and other environmental factors. These changes in conformational states can significantly affect the mechanical properties of the material, such as its strength, elasticity, and durability. Understanding the conformational behavior of polymers is vital for designing new materials with specific characteristics for applications in industries ranging from packaging to aerospace.In conclusion, the concept of conformational changes is fundamental across various scientific disciplines. Whether it is in the context of biological macromolecules or synthetic materials, recognizing how and why these changes occur can lead to significant advancements in our understanding and manipulation of matter. The study of conformational dynamics not only enhances our knowledge of molecular interactions but also paves the way for innovative solutions to complex problems in health, technology, and beyond.

在分子生物学和化学领域，术语conformational指的是由于单键旋转而导致的分子可以采用的不同形状。理解这些conformational变化对于理解分子如何相互作用以及它们如何执行生物功能至关重要。例如，蛋白质由长链氨基酸组成，这些氨基酸可以折叠成各种三维形状。这些形状并不是随机的；它们是由氨基酸之间的肽键的conformational动态决定的。当蛋白质折叠成其功能结构时，它们达到特定的conformational状态，使其能够有效地与其他分子（如底物、抑制剂或其他蛋白质）相互作用。如果蛋白质没有正确折叠，它可能会失去功能，从而导致诸如阿尔茨海默病或囊性纤维化等疾病。因此，研究蛋白质的conformational方面可以提供对其功能和各种疾病机制的深入了解。此外，conformational变化的概念不仅限于蛋白质。核酸，如DNA和RNA，也会经历conformational转变。例如，DNA的双螺旋结构在复制和转录过程中可以解开，从而允许必要的酶访问遗传信息。DNA改变其conformational状态的能力对于细胞过程（如基因表达和调控）至关重要。除了生物分子，术语conformational在材料科学中也被使用。聚合物是由重复结构单元组成的大分子，基于温度、压力和其他环境因素，它们可以表现出各种conformational状态。这些conformational状态的变化可能会显著影响材料的机械性能，例如强度、弹性和耐久性。理解聚合物的conformational行为对于设计具有特定特性的应用于包装到航空航天等行业的新材料至关重要。总之，conformational变化的概念在各个科学学科中都是基础的。无论是在生物大分子的背景下还是在合成材料中，认识到这些变化如何以及为何发生可以为我们理解和操纵物质的重大进展铺平道路。对conformational动态的研究不仅增强了我们对分子相互作用的理解，而且为解决健康、技术等复杂问题提供了创新解决方案。