ionotropic

简明释义

英[ˌaɪəˈnɒtrəpɪk]美[ˌaɪəˈnɑtrəpɪk]

[化学] 离子移变的

英英释义

单词用法

同义词

反义词

例句

1.Explore the application of the two-electrode voltage-clamp technique in the studies of the extrinsic ionotropic receptor expressed.

探索两电极电压钳技术在外源性促离子型受体表达研究中的应用。

2.Objective To explore the application of the two-electrode voltage-clamp technique in the studies of the extrinsic ionotropic receptor expressed by living oocytes.

目的探讨双极电压钳技术在促离子型受体研究中的应用。

3.Objective To explore the application of the two-electrode voltage-clamp technique in the studies of the extrinsic ionotropic receptor expressed by living oocytes.

目的探讨双极电压钳技术在促离子型受体研究中的应用。

4.Explore the application of the two-electrode voltage-clamp technique in the studies of the extrinsic ionotropic receptor.

探索两电极电压钳技术在非本征离子受体研究中的应用。

5.Calcium ions flow through ionotropic receptors during muscle contraction.

肌肉收缩期间，钙离子通过离子型受体流动。

6.The study focused on the role of ionotropic glutamate receptors in synaptic plasticity.

该研究集中于离子型谷氨酸受体在突触可塑性中的作用。

7.Many anesthetics target ionotropic channels to inhibit neuronal activity.

许多麻醉剂靶向离子型通道以抑制神经活动。

8.The drug acts on ionotropic receptors to enhance neurotransmission.

该药物作用于离子型受体以增强神经传递。

9.In the nervous system, ionotropic receptors are crucial for rapid signal transmission.

在神经系统中，离子型受体对快速信号传递至关重要。

作文

The human body is a complex system that relies on various types of signaling mechanisms to maintain homeostasis and facilitate communication between different cells and tissues. One of the most fascinating aspects of this signaling process involves the role of neurotransmitters and their interaction with receptors. Among these receptors, there are two primary types: ionotropic and metabotropic receptors. In this essay, we will focus on the significance of ionotropic receptors and how they contribute to neuronal communication and overall physiological functions.Ionotropic receptors are a class of receptors that can directly open an ion channel upon binding with their respective neurotransmitters. This means that when a neurotransmitter, such as glutamate or gamma-aminobutyric acid (GABA), binds to an ionotropic receptor, it causes a conformational change in the receptor protein that allows ions to flow across the cell membrane. This rapid influx or efflux of ions leads to immediate changes in the electrical potential of the neuron, which can result in excitatory or inhibitory signals being propagated along the neural pathways.The speed at which ionotropic receptors operate is one of their defining characteristics. Unlike metabotropic receptors, which rely on secondary messenger systems and can take longer to elicit a response, ionotropic receptors provide a fast and direct means of communication between neurons. This is particularly important in situations where quick responses are necessary, such as in reflex actions or rapid sensory processing. For example, when you touch a hot surface, the pain signal is transmitted almost instantaneously through ionotropic receptors, allowing you to react quickly and withdraw your hand.Moreover, ionotropic receptors play a crucial role in synaptic plasticity, which is the ability of synapses to strengthen or weaken over time in response to increases or decreases in activity. This is fundamental for learning and memory. The activation of ionotropic receptors can lead to changes in the number of receptors available at the synapse or alter the efficiency of synaptic transmission, thereby influencing the overall strength of the synaptic connection.In addition to their role in normal physiological processes, ionotropic receptors are also implicated in various neurological disorders. Dysregulation of these receptors can lead to conditions such as epilepsy, schizophrenia, and depression. For instance, excessive activation of ionotropic glutamate receptors can result in excitotoxicity, which is the process by which neurons are damaged and killed by excessive stimulation. Understanding the mechanisms behind ionotropic receptor function is therefore essential for developing targeted therapies for these disorders.In conclusion, ionotropic receptors are vital components of the nervous system that facilitate rapid communication between neurons through the direct regulation of ion flow. Their fast-acting nature makes them essential for immediate responses to stimuli, while their involvement in synaptic plasticity underscores their importance in learning and memory. As research continues to advance, a deeper understanding of ionotropic receptors may provide new insights into treating neurological diseases and enhancing cognitive functions. The exploration of these receptors not only sheds light on the fundamental workings of the brain but also opens up avenues for innovative therapeutic strategies that could improve the quality of life for individuals affected by neurological disorders.

人体是一个复杂的系统，依赖各种信号机制来维持稳态并促进不同细胞和组织之间的交流。这个信号过程的一个最迷人的方面是神经递质及其与受体的相互作用。在这些受体中，有两种主要类型：离子型和代谢型受体。在这篇文章中，我们将重点讨论离子型受体的重要性，以及它们如何促进神经元之间的交流和整体生理功能。离子型受体是一类在与各自的神经递质结合时可以直接打开离子通道的受体。这意味着，当神经递质（例如谷氨酸或γ-氨基丁酸（GABA））与离子型受体结合时，会导致受体蛋白的构象变化，从而使离子能够穿过细胞膜。这种离子的快速流入或流出会导致神经元电位的立即变化，从而可能导致兴奋性或抑制性的信号沿神经通路传播。离子型受体运作的速度是其定义特征之一。与依赖二级信使系统、反应时间较长的代谢型受体不同，离子型受体提供了一种快速直接的神经元间通信手段。这在需要快速反应的情况下尤为重要，例如在反射动作或快速感官处理过程中。例如，当你触摸到热表面时，疼痛信号几乎瞬间通过离子型受体传递，使你能够迅速反应并收回手。此外，离子型受体在突触可塑性中也发挥着至关重要的作用，突触可塑性是指突触在活动增加或减少的情况下随时间增强或减弱的能力。这对学习和记忆至关重要。离子型受体的激活可以导致突触处可用受体数量的变化，或改变突触传递的效率，从而影响突触连接的整体强度。除了在正常生理过程中的作用外，离子型受体还与各种神经系统疾病相关。这些受体的失调可能导致癫痫、精神分裂症和抑郁症等情况。例如，离子型谷氨酸受体的过度激活可能导致兴奋毒性，即神经元因过度刺激而受损和死亡的过程。因此，理解离子型受体功能背后的机制对于开发针对这些疾病的靶向治疗至关重要。总之，离子型受体是神经系统的重要组成部分，通过直接调节离子流来促进神经元之间的快速通信。它们的快速作用特性使其在对刺激的即时反应中至关重要，而在突触可塑性中的参与则强调了它们在学习和记忆中的重要性。随着研究的不断深入，对离子型受体的理解可能为治疗神经系统疾病和增强认知功能提供新的见解。对这些受体的探索不仅揭示了大脑的基本运作，还为改善受神经系统疾病影响的个体生活质量的创新治疗策略开辟了新途径。