idiotypic

简明释义

英[ɪdɪəˈtɪpɪk]美[ɪdɪoʊˈtɪpɪk]

个体基因型的

英英释义

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例句

1.Wang J. Li GC Expression, purification and identification of the human anti-idiotypic single chain antibodies against nasopharyngeal carcinoma in E. coli.

汪静。李官成。童永清鼻咽癌人源抗独特型基因工程抗体的原核表达及鉴定。

2.It has been demonstrated that anti-idiotypic antibody vaccines against melanoma can mimic tumor-associated antigens and activate anti-tumor immune responses in many animal models and clinical trials.

黑色素瘤抗独特型抗体疫苗能模拟肿瘤相关抗原，激发机体的抗肿瘤免疫应答，已在许多动物实验和临床试验中得到证实。

3.Objective:To investigate the induction effect of anti-idiotypic antibodies on mice specific low immune reactive state.

目的：探讨抗独特型抗体对小鼠特异性低免疫反应状态的诱导作用。

4.The experiments also demonstrated that 15 of 24 other monoclonal anti-DNA antibodies represented idiotypic cross-reactivity with H241 in different degrees.

实验还证明，24个抗DNA单抗中有15个与H241不同程度地存在独特型交叉反应。

5.AIM: To produce monoclonal anti-idiotypic antibody against uterine cervical cancer and identify its antigenic mimicry properties.

目的：制备宫颈癌抗独特型单克隆抗体并鉴定其抗原模拟特性。

6.Anti-idiotypic antibody NP30 was confirmed with protective immunity of both anti-infection and anti-pathology and may act as a vaccine candidate for schistosomiasis japonica.

以上研究证明日本血吸虫单克隆抗独特型抗体np30具有较好的抗感染免疫和抗病免疫功效，可作为日本血吸虫病疫苗候选分子。

7.The concept of idiotypic 特异性 diversity is crucial for understanding autoimmune diseases.

理解自身免疫病时，特异性特异性多样性的概念至关重要。

8.Researchers are investigating how idiotypic 特异性 variations affect immune responses.

研究人员正在调查特异性特异性变异如何影响免疫反应。

9.Therapeutic antibodies are often designed to target idiotypic 特异性 determinants on cancer cells.

治疗性抗体通常被设计用于靶向癌细胞上的特异性特异性决定因子。

10.In immunology, understanding idiotypic 特异性 networks can help in vaccine development.

在免疫学中，理解特异性特异性网络有助于疫苗开发。

11.The research focused on the idiotypic 特异性 responses of B cells to various antigens.

研究集中在B细胞对各种抗原的特异性特异性反应上。

作文

In the realm of immunology, the concept of idiotypic interactions plays a crucial role in understanding how our immune system recognizes and responds to pathogens. The term idiotypic refers to the unique set of antigenic determinants found on the variable region of an antibody. These determinants are specific to the individual antibody and can vary greatly from one person to another. This variability is essential for the immune system's ability to recognize a vast array of potential threats, such as bacteria and viruses.The significance of idiotypic diversity becomes apparent when we consider the challenges posed by evolving pathogens. For instance, when a virus mutates, it may alter its surface proteins, which are recognized by antibodies. The immune system must then rely on idiotypic variations to produce new antibodies that can effectively bind and neutralize the mutated virus. This adaptability is a hallmark of the immune response, allowing organisms to survive in a constantly changing environment.Moreover, idiotypic networks have been proposed as a mechanism for regulating immune responses. In this model, antibodies can interact with each other based on their idiotypic characteristics. For example, an antibody that binds to a particular antigen might also influence the production of other antibodies with similar or complementary idiotypic profiles. This self-regulating network helps maintain balance within the immune system, preventing overreactions that could lead to autoimmune diseases.Research into idiotypic responses has significant implications for vaccine development. Vaccines aim to elicit a robust immune response by introducing antigens that mimic those of pathogens. Understanding the idiotypic nature of these responses can help scientists design vaccines that produce a diverse array of antibodies, enhancing protection against various strains of a pathogen. For instance, a vaccine that generates a broad idiotypic response may be more effective against influenza, which frequently changes its surface proteins.In addition to its applications in vaccine design, the study of idiotypic interactions can also inform therapeutic strategies for treating diseases like cancer. Tumor cells often express unique antigens that can be targeted by the immune system. By harnessing idiotypic responses, researchers can develop personalized therapies that enhance the body’s ability to recognize and destroy cancer cells. Such approaches hold promise for improving treatment outcomes and reducing side effects compared to traditional therapies.In conclusion, the term idiotypic encapsulates a fundamental aspect of immunology that underscores the importance of diversity and adaptability in our immune responses. From recognizing pathogens to regulating immune activity and informing vaccine and therapy development, idiotypic interactions are vital for maintaining health. As research continues to unravel the complexities of the immune system, the exploration of idiotypic mechanisms will undoubtedly contribute to advancements in medicine and our understanding of human biology.

在免疫学领域，idiotypic相互作用的概念在理解我们的免疫系统如何识别和应对病原体方面发挥着至关重要的作用。术语idiotypic指的是存在于抗体可变区域上的独特抗原决定簇。这些决定簇是特定于个体抗体的，并且可能在不同的人之间有很大差异。这种变异性对于免疫系统识别各种潜在威胁（如细菌和病毒）至关重要。当我们考虑到进化中的病原体所带来的挑战时，idiotypic多样性的意义变得显而易见。例如，当病毒发生突变时，它可能会改变其表面蛋白，这些蛋白会被抗体识别。此时，免疫系统必须依赖于idiotypic变异来产生新的抗体，以有效结合和中和突变后的病毒。这种适应性是免疫反应的一个标志，使生物体能够在不断变化的环境中生存。此外，idiotypic网络被提出作为调节免疫反应的一种机制。在这一模型中，抗体可以基于其idiotypic特征相互作用。例如，一个结合特定抗原的抗体可能也会影响其他具有相似或互补idiotypic特征的抗体的产生。这种自我调节网络有助于维持免疫系统的平衡，防止可能导致自身免疫疾病的过度反应。对idiotypic反应的研究对疫苗开发具有重要意义。疫苗旨在通过引入模拟病原体抗原的物质来引发强烈的免疫反应。理解这些反应的idiotypic特性可以帮助科学家设计出产生多样抗体的疫苗，从而增强对各种病原体株的保护。例如，产生广泛idiotypic反应的疫苗可能对流感更有效，因为流感病毒经常改变其表面蛋白。除了在疫苗设计中的应用之外，研究idiotypic相互作用还可以为治疗癌症等疾病的策略提供信息。肿瘤细胞通常会表达独特的抗原，可以被免疫系统靶向。通过利用idiotypic反应，研究人员可以开发个性化疗法，增强身体识别和摧毁癌细胞的能力。这种方法有望改善治疗效果并减少与传统疗法相比的副作用。总之，术语idiotypic概括了免疫学的一个基本方面，强调了多样性和适应性在我们免疫反应中的重要性。从识别病原体到调节免疫活动，再到指导疫苗和治疗开发，idiotypic相互作用对保持健康至关重要。随着研究不断揭示免疫系统的复杂性，探索idiotypic机制无疑将有助于医学进步以及我们对人类生物学的理解。