pharmacokinetic

简明释义

英[ˌfɑː.mə.kəʊ.kɪˈnɛt.ɪk]美[ˌfɑr.mə.kəˈnɛt.ɪk]

adj. 药代动力学的；药物代谢动力学的（pharmacokinetics 的形容词形式）

英英释义

单词用法

同义词

反义词

例句

1.The main pharmacokinetic parameters showed no difference in genders.

药物动力学参数在性别间没有明显差异。

2.OBJECTIVE: To determine the blood concentration of domestic and foreign lacidipine tablets, and compare their pharmacokinetic parameters.

目的：测定国产与进口拉西地平片剂的血药浓度，进行药动学参数比较。

3.Of course, the pharmacokinetic and pharmacodynamic characteristics differ between drugs.

当然，药物之间药代动力学和药效动力学特点不同。

4.Conclusion The method appeared to be simple, accurate and precise. It is suitable for clinical pharmacokinetic study.

结论本方法简便、准确、精密度好，可用于临床药动学研究。

5.OBJECTIVE To study the pharmacokinetic profiles of isosorbide dinitrate (ISDN) injection in Chinese healthy volunteers.

目的研究硝酸异山梨酯(ISDN)注射剂在中国志愿者中的药动学。

6.Other pharmacokinetic data e. g., results of population studies performed within clinical trial s.

其他药代动力学数据(例如，临床试验进行的人口研究结果)。

7.Researchers are investigating the pharmacokinetic 药代动力学 interactions between these two medications.

研究人员正在调查这两种药物之间的药代动力学相互作用。

8.The pharmacokinetic 药代动力学 data suggested that the drug was rapidly absorbed into the bloodstream.

该药代动力学数据表明，该药物被迅速吸收到血液中。

9.Understanding the pharmacokinetic 药代动力学 profile can help optimize dosing regimens.

理解药代动力学特征可以帮助优化给药方案。

10.The study focused on the pharmacokinetic 药代动力学 properties of the new drug in healthy volunteers.

这项研究集中在新药在健康志愿者中的药代动力学特性上。

11.Clinical trials often evaluate the pharmacokinetic 药代动力学 parameters to ensure safety and efficacy.

临床试验通常评估药代动力学参数以确保安全性和有效性。

作文

Understanding the concept of pharmacokinetic is crucial for anyone studying the field of medicine or pharmacology. Pharmacokinetic refers to the branch of pharmacology concerned with the movement of drugs within the body. This includes how the body absorbs, distributes, metabolizes, and excretes medications. The study of pharmacokinetic properties helps healthcare professionals determine the appropriate dosages and administration routes for various drugs, ensuring their effectiveness while minimizing potential side effects.To break it down further, there are four key processes involved in pharmacokinetic: absorption, distribution, metabolism, and excretion, commonly referred to as ADME. Absorption is the process by which a drug enters the bloodstream after administration. This can vary significantly depending on the route of administration—oral, intravenous, intramuscular, and so forth. For example, a drug administered intravenously will enter the bloodstream immediately, whereas an orally administered drug must first pass through the gastrointestinal tract, which may delay its effects.Next, we have distribution, which describes how the drug disperses throughout the body’s tissues and fluids. Factors such as blood flow, tissue permeability, and the drug's affinity for different tissues can influence distribution. Understanding these factors is essential for predicting how effectively a drug will reach its target site.Metabolism, the third component of pharmacokinetic, involves the chemical alteration of the drug by the body. This usually occurs in the liver, where enzymes convert the drug into metabolites. Some metabolites are active and contribute to the drug's therapeutic effects, while others may be inactive or even toxic. Knowledge of a drug's metabolic pathways can help clinicians anticipate interactions with other medications and adjust dosages accordingly.Finally, excretion is the process by which the body eliminates the drug, primarily through urine or feces. Understanding the excretion route is vital because it can affect the drug's duration of action and the frequency of dosing. For instance, if a drug is primarily excreted by the kidneys, patients with renal impairment may require dosage adjustments to avoid toxicity.The importance of pharmacokinetic studies cannot be overstated in drug development and clinical practice. Through these studies, researchers can identify how different populations—such as children, the elderly, or individuals with pre-existing health conditions—may respond differently to medications. This information is crucial for personalizing treatment plans and improving patient outcomes.In conclusion, the study of pharmacokinetic principles provides invaluable insights into how drugs behave within the body. By understanding absorption, distribution, metabolism, and excretion, healthcare professionals can make informed decisions about medication management. This knowledge ultimately leads to safer and more effective therapeutic interventions, highlighting the significance of pharmacokinetic research in modern medicine. As we continue to advance our understanding of these processes, we can look forward to innovations that will enhance patient care and treatment efficacy.

理解药物动力学的概念对于任何学习医学或药理学领域的人来说都是至关重要的。药物动力学指的是药理学的一个分支，关注药物在体内的运动。这包括身体如何吸收、分配、代谢和排泄药物。研究药物动力学特性有助于医疗专业人员确定各种药物的适当剂量和给药途径，确保其有效性，同时最大限度地减少潜在的副作用。进一步分析，有四个关键过程涉及药物动力学：吸收、分配、代谢和排泄，通常称为ADME。吸收是指药物在给药后进入血液循环的过程。这可能因给药途径的不同而显著变化——口服、静脉注射、肌肉注射等。例如，通过静脉注射给药的药物会立即进入血液，而口服给药的药物必须首先通过胃肠道，这可能会延迟其效果。接下来是分配，它描述了药物如何在身体的组织和液体中分散。血流、组织通透性和药物对不同组织的亲和力等因素都会影响分配。理解这些因素对于预测药物如何有效到达其靶点至关重要。代谢是药物动力学的第三个组成部分，涉及药物在体内的化学改变。这通常发生在肝脏，酶将药物转化为代谢产物。一些代谢产物是活性的，对药物的治疗效果有贡献，而其他一些可能是无效的甚至是有毒的。了解药物的代谢途径可以帮助临床医生预见与其他药物的相互作用，并相应调整剂量。最后，排泄是指身体通过尿液或粪便消除药物的过程。理解排泄途径至关重要，因为这会影响药物的作用持续时间和给药频率。例如，如果一种药物主要通过肾脏排泄，肾功能不全的患者可能需要调整剂量以避免毒性。药物动力学研究的重要性在药物开发和临床实践中不可低估。通过这些研究，研究人员可以识别不同人群（如儿童、老年人或有既往健康状况的个体）对药物的不同反应。这些信息对于个性化治疗计划和改善患者结果至关重要。总之，研究药物动力学原理提供了关于药物在体内行为的宝贵见解。通过理解吸收、分配、代谢和排泄，医疗专业人员可以做出明智的药物管理决策。这种知识最终导致更安全和更有效的治疗干预，突显了药物动力学研究在现代医学中的重要性。随着我们继续推进对这些过程的理解，我们可以期待增强患者护理和治疗效果的创新。