sulfonamides

简明释义

英[sʌlˈfɒnəmaɪdz]美[sʌlˈfɑːnəmaɪdz]

n. 磺胺类药；磺酰胺类

英英释义

单词用法

同义词

反义词

例句

1.The 7-bromo group was replaced with various aniline, and then treated with 4- methoxybenzenesulfonyl chloride to afford the 6-azaindole-1-sulfonamides.

将七号位碳上的溴基取代成各种苯胺类衍生 物，再与4-甲氧基-磺基氯苯反应得到6-氮基吲哚-1-磺胺。

2.The research focuses on the sulfonamides and chloramphenicol, which are used frequently as human and animal medicines.

本研究特别针对人和动物治疗疾病较为常用的磺胺类抗生素和氯霉素给予关注。

3.Range and similar antibacterial sulfonamides, in combination with sulfa drugs or in combination with antibiotics, can significantly improve drug efficacy.

抗菌范围和磺胺类相似，与磺胺药联合使用或与抗菌素联合使用，都可大为提高药物疗效。

4.A rapid method of determining 17 sulfonamides residues by using the 13c6-sulfamethazine as an internal standard in the casing was studied by liquid chromatography-tandem mass spectrometry.

建立了一种以13c6 -磺胺二甲基嘧啶为内标快速测定肠衣中17种磺胺类药物残留量的方法。

5.The sulfonamides, streptomycin, chloramphenicol and other sensitive, but easy to resistance, with R factor is the transfer of plasmid obtained.

对磺胺类、链霉素、氯霉素等敏感，但易耐药，是由带有R因子的质粒转移而获得的。

6.The electron impact and field desorption mass spectra of 10 2,4-diamino-6-substituted quinazoline sulfonamides were investigated.

研究了10种2，4-二氨基-6-取代磺酰胺喹唑啉类药物的电子电离及场解吸质谱。

7.A method for determination of eight sulfonamides residue in royal jelly by using solid-phase extraction high performance liquid chromatography with fluorescence detector was established.

建立蜂王浆中八种磺胺类药物残留的固相萃取-高效液相色谱荧光分析方法。

8.The municipal wastewater discharge is the most important source of sulfonamides in these sites.

城市生活污水排放是入海水域磺胺类污染物的主要来源。

9.Sulfonamides (SM) are foremost medicines to control and cure infectious diseases.

磺胺类药物是控制和治疗传染性疾病的重要药物。

10.In some cases, sulfonamides 磺胺类药物 can be used in combination with other antibiotics for better results.

在某些情况下，磺胺类药物可以与其他抗生素联合使用以获得更好的效果。

11.Doctors often prescribe sulfonamides 磺胺类药物 to treat bacterial infections.

医生通常会开处方磺胺类药物来治疗细菌感染。

12.Patients should be informed about possible side effects of sulfonamides 磺胺类药物, including skin rash and nausea.

患者应被告知磺胺类药物可能的副作用，包括皮疹和恶心。

13.The effectiveness of sulfonamides 磺胺类药物 has decreased due to antibiotic resistance.

由于抗生素耐药性，磺胺类药物的有效性已降低。

14.Some patients may experience allergic reactions to sulfonamides 磺胺类药物, so it's important to monitor them closely.

一些患者可能对磺胺类药物产生过敏反应，因此重要的是要密切观察他们。

作文

Sulfonamides, often referred to as sulfa drugs, represent a significant class of antimicrobial agents that have played a pivotal role in the history of medicine. These compounds were among the first antibiotics discovered and have been used extensively to treat various bacterial infections. The discovery of sulfonamides (磺胺药) in the 1930s marked a turning point in the treatment of infectious diseases, providing an alternative to the then-common practice of using arsenic compounds and other less effective remedies.The mechanism of action of sulfonamides (磺胺药) is quite fascinating. They work by inhibiting the bacterial synthesis of folate, a vital nutrient necessary for the production of DNA and RNA. By blocking the enzyme dihydropteroate synthase, which is involved in the folate synthesis pathway, sulfonamides (磺胺药) effectively starve bacteria of the materials they need to reproduce. This makes them bacteriostatic, meaning they halt bacterial growth rather than kill bacteria outright.One of the most notable aspects of sulfonamides (磺胺药) is their broad-spectrum activity. They are effective against a wide range of gram-positive and some gram-negative bacteria. This versatility made them particularly valuable during World War II, where they were used to treat soldiers suffering from infections that could otherwise lead to severe complications or death. Their ability to prevent infections during surgeries also contributed to advancements in medical practices.However, the use of sulfonamides (磺胺药) has not been without challenges. Over time, many bacteria have developed resistance to these drugs, limiting their efficacy. The emergence of resistant strains has prompted the medical community to seek alternative treatments and develop newer antibiotics. Despite this, sulfonamides (磺胺药) continue to be used in certain situations, particularly in treating urinary tract infections and some types of pneumonia.In addition to their antimicrobial properties, sulfonamides (磺胺药) have also been utilized in the treatment of other medical conditions. For instance, they are sometimes prescribed to manage inflammatory diseases such as ulcerative colitis and rheumatoid arthritis due to their anti-inflammatory effects. This highlights the versatility of sulfonamides (磺胺药) beyond their original purpose as antibiotics.As we look toward the future, the role of sulfonamides (磺胺药) in medicine will likely continue to evolve. Ongoing research aims to understand better how to combat bacterial resistance and improve the effectiveness of existing drugs. Moreover, the development of combination therapies, where sulfonamides (磺胺药) are used alongside other antibiotics, may provide new avenues for treatment.In conclusion, sulfonamides (磺胺药) have made significant contributions to the field of medicine since their discovery. Their ability to treat bacterial infections and their applications in other medical conditions underscore their importance. While challenges such as antibiotic resistance persist, the ongoing research and potential for new therapeutic strategies ensure that sulfonamides (磺胺药) will remain a relevant topic in medical discussions for years to come.

磺胺药，通常被称为磺胺类药物，代表了一类重要的抗微生物药物，在医学历史上发挥了重要作用。这些化合物是发现的第一批抗生素之一，并广泛用于治疗各种细菌感染。sulfonamides（磺胺药）在20世纪30年代的发现标志着传染病治疗的一个转折点，为当时常用的砷化合物和其他效果较差的疗法提供了替代方案。sulfonamides（磺胺药）的作用机制非常有趣。它们通过抑制细菌合成叶酸的过程来发挥作用，叶酸是DNA和RNA合成所需的重要营养物质。通过阻断参与叶酸合成途径的二氢蝶呤酸合成酶，这些药物有效地使细菌缺乏繁殖所需的材料。这使得sulfonamides（磺胺药）具有抑菌作用，即阻止细菌生长而不是直接杀死细菌。sulfonamides（磺胺药）最引人注目的方面之一是它们的广谱活性。它们对多种革兰阳性和某些革兰阴性细菌有效。这种多样性使得它们在第二次世界大战期间尤为珍贵，当时它们被用来治疗士兵因感染而可能导致严重并发症或死亡的情况。它们在手术期间预防感染的能力也促进了医学实践的发展。然而，sulfonamides（磺胺药）的使用并非没有挑战。随着时间的推移，许多细菌对这些药物产生了抗药性，限制了它们的效力。耐药菌株的出现促使医学界寻找替代治疗方法并开发更新的抗生素。尽管如此，sulfonamides（磺胺药）仍然在某些情况下继续使用，特别是在治疗尿路感染和某些类型的肺炎方面。除了抗微生物特性外，sulfonamides（磺胺药）还被用于治疗其他医疗条件。例如，由于其抗炎作用，它们有时被开用于管理溃疡性结肠炎和类风湿性关节炎等炎症性疾病。这突显了sulfonamides（磺胺药）在其原始用途之外的多样性。展望未来，sulfonamides（磺胺药）在医学中的作用可能会继续演变。持续的研究旨在更好地理解如何应对细菌抗药性并提高现有药物的有效性。此外，结合疗法的发展，即将sulfonamides（磺胺药）与其他抗生素一起使用，可能为治疗提供新的途径。总之，sulfonamides（磺胺药）自发现以来对医学领域作出了重大贡献。它们治疗细菌感染的能力及其在其他医疗条件中的应用突显了它们的重要性。尽管抗生素耐药性等挑战依然存在，但持续的研究和新治疗策略的潜力确保了sulfonamides（磺胺药）在未来几年仍将是医学讨论的相关话题。