leukemogenesis

简明释义

英[luːˌkiːməˈdʒenɪsɪs]美[luːkiːməˈdʒenɪsɪs]

n. 白血病生成

英英释义

单词用法

同义词

反义词

例句

1.Objective To investigate the changes of telomerase activity and its related genes expression in leukemia cells and their roles in leukemogenesis.

目的研究端粒酶活性和相关基因表达在白血病患者中的变化及其在白血病发病机制中的意义。

2.Objective To elucidate the expression and regulation of interleukin 18 (IL 18) in human leukemia cell line J6 1, and investigate its possible role in leukemogenesis.

目的阐明白细胞介素18 (IL 18)在人白血病细胞系J 61的表达与调控，探讨IL 18在白血病发生中的意义。

3.Background and objective: the hypothesis of "two hit" model suggests that at least two classes of gene mutations are responsible for the leukemogenesis.

背景与目的：“两次打击”学说认为，白血病的发生常常累及两大类以上基因的突变。

4.The stem cell leukemia(SCL) gene is a new oncogene related with leukemogenesis.

干细胞白血病（SCL）基因是新发现的与白血病发生有关的癌基因。

5.Objective To elucidate the expression and regulation of interleukin 18 (IL 18) in human leukemia cell line J6 1, and investigate its possible role in leukemogenesis.

目的阐明白细胞介素18 (IL 18)在人白血病细胞系J 61的表达与调控，探讨IL 18在白血病发生中的意义。

6.The aim of the study was to evaluate the role of the HCP gene in leukemogenesis.

本研究旨在评价HCP基因突变在急性白血病发病中的作用。

7.The stem cell leukemia (SCL) gene is a new oncogene related with leukemogenesis.

干细胞白血病(CL)因是新发现的与白血病发生有关的癌基因。

8.These alterations in the histone code may alter gene expression pattern to set the stage for leukemogenesis.

组蛋白密码的这些改变可能改变基因表达模式以设定白血病发生状态。

9.The discovery of specific biomarkers has advanced our knowledge of leukemogenesis 白血病发生 in pediatric populations.

特定生物标志物的发现推动了我们对儿童群体中leukemogenesis 白血病发生的认识。

10.Understanding the mechanisms of leukemogenesis 白血病发生 is crucial for improving patient outcomes.

理解leukemogenesis 白血病发生的机制对于改善患者预后至关重要。

11.Clinical trials are underway to test new drugs that target pathways involved in leukemogenesis 白血病发生.

临床试验正在进行中，以测试针对参与leukemogenesis 白血病发生的途径的新药物。

12.Researchers are studying the role of genetic mutations in leukemogenesis 白血病发生 to develop targeted therapies.

研究人员正在研究基因突变在leukemogenesis 白血病发生中的作用，以开发靶向治疗。

13.Environmental factors can influence the process of leukemogenesis 白血病发生, leading to increased risk in certain populations.

环境因素可以影响leukemogenesis 白血病发生的过程，导致某些人群风险增加。

作文

Leukemia is a type of cancer that affects the blood and bone marrow, leading to the overproduction of abnormal white blood cells. Understanding the process of leukemogenesis is crucial for developing effective treatments and therapies for this disease. Leukemogenesis refers to the complex series of events that lead to the transformation of normal hematopoietic stem cells into malignant leukemic cells. This process can be triggered by various genetic mutations, environmental factors, and even certain infections.The initial stage of leukemogenesis often involves the acquisition of genetic mutations that disrupt normal cell signaling pathways. These mutations can arise from exposure to carcinogens, such as radiation or certain chemicals, or they may occur spontaneously during DNA replication. One common mutation associated with leukemogenesis is the Philadelphia chromosome, which results from a translocation between chromosomes 9 and 22. This genetic alteration leads to the production of the BCR-ABL fusion protein, which promotes uncontrolled cell division and inhibits apoptosis, or programmed cell death.As the disease progresses, additional mutations accumulate in the leukemic cells, further driving their proliferation and survival. This clonal evolution of the leukemic population contributes to the heterogeneity observed in leukemia patients, making it challenging to develop one-size-fits-all treatment strategies. For instance, some leukemic cells may become resistant to chemotherapy due to mutations that enable them to evade the effects of drugs designed to kill them.In addition to genetic factors, the microenvironment surrounding the hematopoietic cells plays a significant role in leukemogenesis. The bone marrow niche provides essential signals that support the survival and growth of both normal and malignant cells. Interactions between leukemic cells and their microenvironment can enhance their resistance to therapy and promote disease progression. Understanding these interactions is vital for identifying new therapeutic targets that could improve patient outcomes.Research into leukemogenesis has also highlighted the importance of epigenetic changes in the development of leukemia. Epigenetics refers to modifications in gene expression that do not involve changes to the underlying DNA sequence. These changes can be influenced by environmental factors and lifestyle choices, potentially providing avenues for prevention and intervention. For example, studies have shown that certain dietary components and physical activity levels can impact the epigenetic landscape, thereby influencing the risk of developing leukemia.In conclusion, leukemogenesis is a multifaceted process involving genetic mutations, environmental influences, and interactions with the bone marrow microenvironment. A comprehensive understanding of these mechanisms is essential for advancing our knowledge of leukemia and developing targeted therapies. Continued research in this area will hopefully lead to improved diagnostic tools and treatment options, ultimately benefiting patients affected by this challenging disease.

白血病是一种影响血液和骨髓的癌症，导致异常白细胞的过度产生。理解leukemogenesis的过程对于开发有效的治疗和疗法至关重要。Leukemogenesis指的是将正常造血干细胞转变为恶性白血病细胞的复杂事件系列。这个过程可能由各种基因突变、环境因素，甚至某些感染引发。Leukemogenesis的初始阶段通常涉及获得破坏正常细胞信号通路的基因突变。这些突变可能源于接触致癌物，例如辐射或某些化学物质，或者在DNA复制过程中自发发生。与leukemogenesis相关的一个常见突变是费城染色体，它是染色体9和22之间的易位所致。这种基因改变导致BCR-ABL融合蛋白的产生，从而促进细胞的无控制分裂并抑制凋亡，即程序性细胞死亡。随着疾病的进展，白血病细胞中会积累更多的突变，进一步推动它们的增殖和存活。白血病群体的克隆进化导致患者观察到的异质性，使得开发一刀切的治疗策略变得具有挑战性。例如，由于突变使其能够逃避旨在杀死它们的药物的影响，一些白血病细胞可能对化疗产生耐药性。除了基因因素外，围绕造血细胞的微环境在leukemogenesis中也起着重要作用。骨髓生态位提供了支持正常和恶性细胞生存和生长的基本信号。白血病细胞与其微环境之间的相互作用可以增强其对治疗的耐受性并促进疾病进展。理解这些相互作用对于识别新的治疗靶点至关重要，这可能改善患者的结果。对leukemogenesis的研究还强调了表观遗传变化在白血病发展中的重要性。表观遗传学是指不涉及基础DNA序列变化的基因表达修饰。这些变化可能受到环境因素和生活方式选择的影响，潜在地提供预防和干预的途径。例如，研究表明，某些饮食成分和身体活动水平可以影响表观遗传景观，从而影响白血病的发展风险。总之，leukemogenesis是一个多方面的过程，涉及基因突变、环境影响和与骨髓微环境的相互作用。全面理解这些机制对于推进我们对白血病的认识和开发靶向疗法至关重要。在这一领域的持续研究将希望带来更好的诊断工具和治疗选择，最终使受此挑战性疾病影响的患者受益。