methylate

简明释义

英[ˈmeθɪˌleɪt]美[ˈmeθəˌlet]

v. 在……中加入甲醛（或甲基化酒精）；（使）甲基化

n. 甲醇盐

第 三 人 称 单 数 m e t h y l a t e s

现 在 分 词 m e t h y l a t i n g

过 去 式 m e t h y l a t e d

过 去 分 词 m e t h y l a t e d

英英释义

单词用法

同义词

反义词

例句

1.In the 2-4 hour, the increasing speed of methylate shoot up and exceeded the level of demethylation. In the 4-16 hour, the level of methylation went to stable and kept on the higher level.

而在2 -4小时期间，甲基化水平迅速上升，并超过去甲基化水平，在4 - 16小时期间甲基化水平趋于稳定，并且始终高于去甲基化水平。

2.Conclusion Carboprost methylate suppositories with oxytocin on prevention of postpartum hemorrhage has reliable effect and good security, which is worthy of clinical application.

结论应用卡前列甲酯栓联合催产素预防产后出血疗效可靠，具有良好的安全性，建议临床推广应用。

3.Specific methylase enzymes were isolated from M. mycoides and used to methylate the M. mycoides genome isolated from yeast.

丝状支原体中分离出特异性的甲基酶，进而用该酶甲基化酵母中提取出的丝状支原体基因组。

4.In the 2-4 hour, the increasing speed of methylate shoot up and exceeded the level of demethylation. In the 4-16 hour, the level of methylation went to stable and kept on the higher level.

而在2 -4小时期间，甲基化水平迅速上升，并超过去甲基化水平，在4 - 16小时期间甲基化水平趋于稳定，并且始终高于去甲基化水平。

5.AIM: To observe the efficacy of carboprost methylate suppository after the failure of induced term labor by oxytocin.

目的：观察足月妊娠用缩宫素引产失败后再用卡前列甲酯栓的疗效。

6.Scientists often use enzymes to methylate DNA, which can affect gene expression.

科学家们常常使用酶来甲基化DNA，这会影响基因表达。

7.Researchers are looking into how environmental factors can methylate genes and influence health.

研究人员正在研究环境因素如何甲基化基因并影响健康。

8.In cancer research, understanding how tumors methylate genes can lead to new treatment strategies.

在癌症研究中，了解肿瘤如何甲基化基因可以引导新的治疗策略。

9.The process of methylating histones is crucial for regulating chromatin structure.

对组蛋白进行甲基化的过程对调节染色质结构至关重要。

10.Certain drugs are designed to methylate specific targets in the body to enhance their effects.

某些药物旨在甲基化体内特定靶点以增强其效果。

作文

Methylation is a crucial biochemical process that involves the addition of a methyl group to a molecule, often DNA. This process can significantly influence gene expression and cellular function. One specific term associated with this process is methylate, which refers to the action of attaching a methyl group to a substrate. Understanding how to methylate certain compounds is essential for various fields, including genetics, pharmacology, and biochemistry.In genetics, the methylation of DNA plays a vital role in regulating gene expression. When genes are methylated, they can be silenced, meaning that the corresponding proteins are not produced. This regulation is crucial during development, as it allows cells to differentiate and specialize. For instance, in embryonic development, certain genes need to be methylated to ensure that stem cells develop into specific cell types like muscle or nerve cells.The process of methylating DNA is carried out by enzymes known as DNA methyltransferases. These enzymes transfer a methyl group from a donor molecule, usually S-adenosyl methionine (SAM), to cytosine bases in the DNA sequence. The addition of this methyl group can alter the structure of the DNA, making it less accessible for transcription factors and other proteins that are necessary for gene expression. As a result, the methylation status of a gene can determine whether it is active or inactive.Beyond genetics, the ability to methylate compounds also has significant implications in pharmacology. Many drugs are designed to interact with specific biological pathways, and understanding how to methylate certain drugs can enhance their efficacy or reduce side effects. For example, some medications may require methylation to activate their therapeutic properties. Conversely, unwanted methylation can lead to drug resistance or toxicity.Furthermore, environmental factors such as diet and exposure to toxins can influence the methylation patterns in our bodies. For instance, nutrients like folate, vitamin B12, and choline are essential for providing the necessary components for methylation. A deficiency in these nutrients can lead to altered methylation patterns, which may increase the risk of various diseases, including cancer.In summary, the ability to methylate molecules is a fundamental aspect of biological processes that affects gene regulation, drug metabolism, and overall health. As research continues to uncover the complexities of methylation, it becomes increasingly clear that this process is not just a biochemical curiosity but a pivotal mechanism that underlies many aspects of life. Understanding how to manipulate and study methylation could lead to advances in medical treatments and a better understanding of genetic diseases. Therefore, the study of methylation and the ability to methylate compounds will remain a critical area of research in the years to come.

甲基化是一个重要的生化过程，涉及到将甲基团添加到分子上，通常是DNA。这个过程可以显著影响基因表达和细胞功能。与这一过程相关的一个特定术语是methylate，它指的是将甲基团附加到底物上的动作。了解如何methylate某些化合物对遗传学、药理学和生物化学等多个领域至关重要。在遗传学中，DNA的甲基化在调节基因表达中起着至关重要的作用。当基因被甲基化时，它们可能会被沉默，这意味着相应的蛋白质不会产生。这种调节在发育过程中至关重要，因为它使细胞能够分化和专业化。例如，在胚胎发育过程中，某些基因需要被甲基化以确保干细胞发育成特定的细胞类型，如肌肉或神经细胞。DNA的甲基化过程由被称为DNA甲基转移酶的酶来执行。这些酶将甲基团从供体分子（通常是S-腺苷甲硫氨酸，SAM）转移到DNA序列中的胞嘧啶碱基上。这个甲基团的添加可以改变DNA的结构，使其对转录因子和其他必要的蛋白质的可及性降低。因此，基因的甲基化状态可以决定其是否活跃。除了遗传学，能够甲基化化合物在药理学中也具有重要意义。许多药物旨在与特定的生物途径相互作用，了解如何甲基化某些药物可以增强其疗效或减少副作用。例如，一些药物可能需要经过甲基化才能激活其治疗特性。相反，不必要的甲基化可能导致药物耐药性或毒性。此外，饮食和接触毒素等环境因素可以影响我们身体中的甲基化模式。例如，营养素如叶酸、维生素B12和胆碱是提供进行甲基化所需成分的重要物质。这些营养素的缺乏可能导致甲基化模式的改变，从而增加各种疾病的风险，包括癌症。总之，能够甲基化分子是生物过程的基本方面，影响基因调控、药物代谢和整体健康。随着研究不断揭示甲基化的复杂性，越来越清楚这一过程不仅仅是生化好奇，而是潜在机制，支撑着生活的许多方面。理解如何操纵和研究甲基化可能会导致医疗治疗的进步和对遗传疾病的更好理解。因此，对甲基化的研究以及能够甲基化化合物将继续成为未来几年内的重要研究领域。