methyldopa

简明释义

英[ˌmiːθaɪlˈdəʊpə]美[ˌmeθəlˈdoʊpə]

n. （药物）[药] 甲基多巴（降血压药）

英英释义

单词用法

同义词

反义词

例句

1.The preferred agents are methyldopa for prolonged antenatal therapy, and hydralazine, labetalol or nifedipine for peripartum treatment of acute hypertensive episodes.

长期产前治疗首选的药物是甲基多巴，围产期急性高血压发作的治疗可用拉贝·洛尔或心痛定。

2.Methyldopa and hydralazine have been most widely used in pregnant women and their longterm safety for the fetus has been demonstrated. ACE inhibitors should not be continued in pregnancy.

甲基多巴和肼屈嗪已经广泛应用于妊娠妇女，它们对胎儿的长期安全性也被证实，ACE抑制剂在怀孕时不应持续应用。

3.Methyldopa and hydralazine have been most widely used in pregnant women and their longterm safety for the fetus has been demonstrated. ACE inhibitors should not be continued in pregnancy.

甲基多巴和肼屈嗪已经广泛应用于妊娠妇女，它们对胎儿的长期安全性也被证实，ACE抑制剂在怀孕时不应持续应用。

4.The preferred agents are methyldopa for prolonged antenatal therapy , and hydralazine, labetalol or nifedipine for peripartum treatment of acute hypertensive episodes .

长期产前治疗首选的药物是甲基多巴，围产期急性高血压发作的治疗可用拉贝洛尔或心痛定。

5.OBJECTIVE To identify the structure of L-methyldopa.

目的确证L-甲基多巴的结构。

6.The doctor prescribed methyldopa to help manage her high blood pressure.

医生开了甲基多巴来帮助控制她的高血压。

7.She experienced dizziness after starting methyldopa treatment.

在开始治疗甲基多巴后，她感到头晕。

8.During pregnancy, methyldopa is often recommended as a safe antihypertensive.

在怀孕期间，通常推荐使用甲基多巴作为安全的抗高血压药物。

9.The effectiveness of methyldopa can vary from patient to patient.

每位患者对甲基多巴的效果可能有所不同。

10.Patients taking methyldopa should be monitored for any side effects.

服用甲基多巴的患者应该监测任何副作用。

作文

Methyldopa is a medication that has been widely used for the treatment of hypertension, particularly in pregnant women. It belongs to a class of drugs known as centrally acting alpha-2 adrenergic agonists. The mechanism of action of methyldopa involves its conversion in the body to alpha-methyl norepinephrine, which then stimulates alpha-2 adrenergic receptors in the central nervous system. This stimulation results in a decrease in sympathetic outflow from the brain, leading to lower blood pressure. One of the significant advantages of methyldopa is its safety profile during pregnancy. High blood pressure can pose serious risks to both the mother and the fetus, including preeclampsia and low birth weight. Therefore, the use of methyldopa has been recommended due to its effectiveness and minimal side effects compared to other antihypertensive medications. However, like any medication, it is not without potential adverse effects. Common side effects may include drowsiness, dry mouth, and fatigue, while more severe reactions can occur in rare cases.In clinical practice, it is essential for healthcare providers to monitor patients taking methyldopa closely. Regular blood pressure checks and assessments for side effects are necessary to ensure the medication is working effectively and safely. Additionally, patient education plays a crucial role in the management of hypertension with methyldopa. Patients should be informed about how to take the medication correctly, the importance of adherence to prescribed doses, and what side effects to watch for.The history of methyldopa dates back to the 1960s when it was first introduced as an antihypertensive agent. Over the decades, numerous studies have demonstrated its efficacy in controlling blood pressure, especially in populations at risk, such as pregnant women. Its ability to cross the blood-brain barrier and exert effects on the central nervous system distinguishes methyldopa from other antihypertensive drugs that primarily act on the peripheral vasculature.In conclusion, methyldopa remains a cornerstone in the management of hypertension, particularly in special populations like pregnant women. Its unique mechanism of action, combined with a favorable safety profile, makes it an invaluable tool in preventing complications associated with high blood pressure. As with any medication, ongoing research and clinical experience will continue to refine our understanding of methyldopa and its role in hypertension management. Ultimately, the goal is to provide safe and effective treatment options that improve patient outcomes and quality of life.

甲基多巴是一种广泛用于治疗高血压的药物，特别是在孕妇中。它属于一类称为中枢作用的α-2肾上腺素能激动剂的药物。甲基多巴的作用机制涉及其在体内转化为α-甲基去甲肾上腺素，这种物质刺激中枢神经系统中的α-2肾上腺素受体。这种刺激导致来自大脑的交感神经输出减少，从而降低血压。甲基多巴的一个显著优势是其在妊娠期间的安全性。高血压可能对母亲和胎儿造成严重风险，包括子痫前期和低出生体重。因此，由于其有效性和相较于其他抗高血压药物的最小副作用，推荐使用甲基多巴。然而，像任何药物一样，它也并非没有潜在的不良反应。常见的副作用包括嗜睡、口干和疲劳，而在少数情况下可能会出现更严重的反应。在临床实践中，医疗提供者必须密切监测服用甲基多巴的患者。定期检查血压和评估副作用是确保药物有效且安全的重要措施。此外，患者教育在使用甲基多巴管理高血压中起着至关重要的作用。应该告知患者如何正确服用药物、遵守处方剂量的重要性以及需要注意的副作用。甲基多巴的历史可以追溯到20世纪60年代，当时它首次被引入作为抗高血压剂。在几十年的研究中，许多研究证明了其在控制血压方面的有效性，尤其是在高风险人群中，如孕妇。它能够穿过血脑屏障并对中枢神经系统产生作用，使得甲基多巴与主要作用于外周血管的其他抗高血压药物区别开来。总之，甲基多巴仍然是高血压管理中的基石，特别是在孕妇等特殊人群中。其独特的作用机制，加上良好的安全性，使其成为防止高血压相关并发症的宝贵工具。与任何药物一样，持续的研究和临床经验将继续深化我们对甲基多巴及其在高血压管理中角色的理解。最终目标是提供安全有效的治疗方案，以改善患者的预后和生活质量。