idiotype

简明释义

英[ˈɪdɪəʊˌtaɪp]美[ˈɪdiəˌtaɪp]

n. [免疫] 个体基因型；个体遗传型；特异基因型

英英释义

单词用法

同义词

反义词

例句

1.In order to reduce the human anti mouse antibody response and obtain optimal antigenicity, anti idiotype single chain which mimicking ovarian cancer antigen has been humanized.

为了降低人抗鼠抗体反应，获得满意的免疫原性，将模拟人卵巢癌抗原的抗独特型单链抗体人源化。

2.Scientists call this claw shape the antibody molecule's idiotype.

科学家称这种爪型为抗体微小颗粒的遗传型。

3.To explore the preparation of specific immune RNA on idiotype and further study immunotherapy of tumors.

为进一步研究肿瘤的免疫治疗，探索一种型特异、体专一的肿瘤免疫核糖核酸的制备方法。

4.In order to reduce the human anti mouse antibody response and obtain optimal antigenicity, anti idiotype single chain which mimicking ovarian cancer antigen has been humanized.

为了降低人抗鼠抗体反应，获得满意的免疫原性，将模拟人卵巢癌抗原的抗独特型单链抗体人源化。

5.Understanding the idiotype 特异性表位 of antibodies can help in designing better therapeutic agents.

理解抗体的idiotype 特异性表位可以帮助设计更好的治疗药物。

6.The immune response is highly specific, often targeting a unique idiotype 特异性表位 of the pathogen.

免疫反应是高度特异性的，通常针对病原体的独特idiotype 特异性表位。

7.In monoclonal antibody production, scientists select for a specific idiotype 特异性表位 to ensure targeted therapy.

在单克隆抗体生产中，科学家选择特定的idiotype 特异性表位以确保靶向治疗。

8.The diversity of idiotype'>特异性表位 in a population can affect overall immunity.

群体中idiotype'>特异性表位的多样性可以影响整体免疫力。

9.Researchers are studying how different idiotypes 特异性表位 can influence vaccine effectiveness.

研究人员正在研究不同的idiotypes 特异性表位 如何影响疫苗的有效性。

作文

In the fascinating world of immunology, the term idiotype refers to the unique set of antigenic determinants that are present on the variable region of an antibody. This concept is crucial for understanding how our immune system recognizes and responds to pathogens. Each antibody produced by a B cell has a distinct idiotype, which allows it to bind specifically to a particular antigen. This specificity is paramount in the immune response, as it ensures that the body can target and eliminate foreign invaders effectively.The idea of idiotype is intricately linked to the broader concept of the immune repertoire. Our immune system generates a diverse array of antibodies, each with its own idiotype, enabling it to recognize a vast range of antigens. This diversity is achieved through a process called somatic recombination, where gene segments are rearranged to create unique antibody genes. Consequently, each B cell that matures will express a different idiotype, contributing to the overall capability of the immune system to combat infections.Moreover, the study of idiotypes extends beyond basic immunology. It plays a significant role in vaccine development and therapeutic interventions. By understanding the idiotype of antibodies generated in response to a specific pathogen, researchers can design vaccines that elicit a strong and targeted immune response. For instance, if a vaccine can induce antibodies with a similar idiotype to those produced during a natural infection, it may provide effective protection against that disease.In addition, idiotype also has implications in the field of autoimmunity. In certain autoimmune diseases, the immune system mistakenly targets the body's own tissues. Understanding the idiotype involved in these responses can help identify potential therapeutic strategies. By developing treatments that modulate the activity of specific idiotype antibodies, it may be possible to reduce the harmful effects of autoimmune reactions.Furthermore, the concept of idiotype is not limited to antibodies alone; it can also apply to T cell receptors (TCRs). Just like antibodies, TCRs have unique idiotypes that determine their specificity for recognizing antigens presented by major histocompatibility complex (MHC) molecules. This highlights the importance of idiotype in both humoral and cellular immunity, showcasing the complexity of our immune defense mechanisms.In conclusion, the term idiotype encapsulates a fundamental aspect of immunology, representing the unique characteristics of antibodies and their role in the immune response. Understanding idiotype is vital for advancements in vaccine development, therapeutic interventions for autoimmune diseases, and comprehending the intricacies of immune system functioning. As research continues to evolve, the significance of idiotype will undoubtedly expand, offering new insights into how we can harness the power of our immune system to fight against diseases effectively.

在免疫学的迷人世界中，术语idiotype指的是存在于抗体可变区域上的独特抗原决定簇。这个概念对于理解我们的免疫系统如何识别和应对病原体至关重要。每个由B细胞产生的抗体都有一个独特的idiotype，这使它能够特异性地结合到特定抗原上。这种特异性在免疫反应中是至关重要的，因为它确保身体能够有效地针对并消灭外来入侵者。idiotype的概念与免疫库的更广泛概念密切相关。我们的免疫系统生成多样化的抗体，每种都有自己的idiotype，使其能够识别各种抗原。这种多样性是通过一种称为体细胞重组的过程实现的，其中基因片段被重新排列以创建独特的抗体基因。因此，每个成熟的B细胞将表达不同的idiotype，从而增强免疫系统对抗感染的整体能力。此外，idiotype的研究超越了基础免疫学。它在疫苗开发和治疗干预中发挥着重要作用。通过理解针对特定病原体生成的抗体的idiotype，研究人员可以设计出能够引发强烈和针对性的免疫反应的疫苗。例如，如果一种疫苗能够诱导产生与自然感染期间产生的抗体具有相似idiotype的抗体，它可能会提供有效的保护。此外，idiotype在自身免疫领域也有重要意义。在某些自身免疫疾病中，免疫系统错误地攻击身体自身的组织。了解涉及这些反应的idiotype可以帮助识别潜在的治疗策略。通过开发调节特定idiotype抗体活性的治疗方法，可能能够减少自身免疫反应的有害影响。此外，idiotype的概念不仅限于抗体；它也适用于T细胞受体（TCR）。就像抗体一样，TCR具有独特的idiotype，决定其对由主要组织相容性复合体（MHC）分子呈递的抗原的特异性。这突显了idiotype在体液免疫和细胞免疫中的重要性，展示了我们免疫防御机制的复杂性。总之，术语idiotype概括了免疫学的一个基本方面，代表了抗体的独特特征及其在免疫反应中的作用。理解idiotype对于疫苗开发、治疗自身免疫疾病的干预以及理解免疫系统功能的复杂性至关重要。随着研究的不断发展，idiotype的重要性无疑会扩大，为我们如何有效利用免疫系统的力量来对抗疾病提供新的见解。