heteroduplex

简明释义

英[/ˌhɛtəˈrʊplɛks/]美[/ˌhɛtəˈrʊplɛks/]

n. 异源双链核酸分子

adj. 异源双链核酸分子的

英英释义

单词用法

同义词

反义词

例句

1.Methods We used heteroduplex mobility analysis (HMA) and sequencing to detect mixed infection.

方法使用异双体动态分析法和测序检测混合感染。

2.Objective:To assess the roles of single stranded conformation polymorphism(SSCP)and heteroduplex polymorphism(HET)in screening gene mutation.

目的：评价异源双链分析（HET）和单链构象多态性分析（SSCP）在基因突变检测中的作用。

3.Objective:To assess the roles of single stranded conformation polymorphism(SSCP)and heteroduplex polymorphism(HET)in screening gene mutation.

目的：评价异源双链分析（HET）和单链构象多态性分析（SSCP）在基因突变检测中的作用。

4.In genetic research, scientists often analyze heteroduplex 异源双链 formations to study mutations.

在遗传研究中，科学家们经常分析异源双链的形成以研究突变。

5.The presence of heteroduplex 异源双链 DNA can indicate the occurrence of recombination events.

存在异源双链DNA可能表明重组事件的发生。

6.The heteroduplex 异源双链 method is crucial for understanding genetic diversity.

使用异源双链方法对于理解遗传多样性至关重要。

7.By creating heteroduplex 异源双链 molecules, scientists can explore gene interactions.

通过创建异源双链分子，科学家可以探索基因之间的相互作用。

8.Researchers used heteroduplex 异源双链 analysis to identify variations in the gene sequence.

研究人员使用异源双链分析来识别基因序列中的变异。

作文

In the field of molecular biology, the term heteroduplex refers to a double-stranded nucleic acid molecule that contains strands from different sources. This phenomenon occurs when two single-stranded DNA or RNA molecules, which may have some degree of sequence similarity but are not identical, hybridize to form a stable double helix. The study of heteroduplex formation is crucial for understanding genetic recombination, mutation, and various biological processes. To elaborate, heteroduplex molecules can arise during the process of genetic recombination, where segments of DNA from homologous chromosomes exchange genetic material. This exchange can lead to genetic diversity, which is essential for evolution and adaptation in living organisms. Moreover, the presence of mismatched base pairs within a heteroduplex can indicate areas of genetic variation, which researchers often analyze to understand population genetics and evolutionary relationships.One of the significant applications of studying heteroduplex molecules is in the field of genetic engineering and biotechnology. For instance, scientists can create heteroduplex DNA to introduce specific mutations into a gene of interest. By doing so, they can study the effects of those mutations on gene function and protein expression. This approach has been instrumental in developing gene therapies and understanding genetic disorders, as it allows researchers to pinpoint the exact locations and nature of genetic defects.Additionally, heteroduplex analysis is utilized in techniques such as heteroduplex mobility assay (HMA) and temperature gradient gel electrophoresis (TGGE). These methods enable scientists to detect mutations and polymorphisms in DNA samples. For example, in clinical diagnostics, the identification of mutations associated with diseases can lead to better-targeted treatments and personalized medicine strategies.Furthermore, the concept of heteroduplex extends beyond just nucleic acids. In a broader context, it can also refer to the interaction between different proteins or other macromolecules that form complexes with varying functions. Understanding these interactions is vital for deciphering cellular processes and developing pharmaceuticals that target specific pathways.In conclusion, the term heteroduplex encompasses a fundamental aspect of molecular biology, emphasizing the importance of genetic variability and interaction. As research advances, the implications of heteroduplex studies will continue to play a pivotal role in genetics, biotechnology, and medicine. Mastery of this concept not only enhances our comprehension of genetic mechanisms but also opens doors to innovative solutions for health-related challenges. Thus, the exploration of heteroduplex structures and their functions remains an exciting frontier in biological research, promising new insights and advancements in science and technology.

在分子生物学领域，术语heteroduplex指的是一种由不同来源的链组成的双链核酸分子。这种现象发生在两个单链DNA或RNA分子之间，它们可能具有一定程度的序列相似性但并不完全相同，当它们杂交形成稳定的双螺旋时，就会产生heteroduplex。研究heteroduplex的形成对于理解基因重组、突变及各种生物过程至关重要。进一步说，heteroduplex分子可以在基因重组过程中产生，其中同源染色体的DNA片段交换遗传物质。这种交换会导致遗传多样性，这对生物体的进化和适应至关重要。此外，heteroduplex中存在的不匹配碱基对可以指示遗传变异的区域，研究人员通常分析这些区域以了解种群遗传学和进化关系。研究heteroduplex分子的一个重要应用是在基因工程和生物技术领域。例如，科学家可以创建heteroduplex DNA，以将特定突变引入感兴趣的基因。通过这种方式，他们可以研究这些突变对基因功能和蛋白质表达的影响。这种方法在开发基因治疗和理解遗传疾病方面发挥了重要作用，因为它允许研究人员精确定位和了解遗传缺陷的性质。此外，heteroduplex分析还用于诸如异链移动性分析（HMA）和温度梯度凝胶电泳（TGGE）等技术。这些方法使科学家能够检测DNA样本中的突变和多态性。例如，在临床诊断中，识别与疾病相关的突变可以导致更有针对性的治疗和个性化医学策略。此外，heteroduplex的概念不仅限于核酸。在更广泛的上下文中，它还可以指不同蛋白质或其他大分子之间的相互作用，这些相互作用形成具有不同功能的复合物。理解这些相互作用对于解读细胞过程和开发针对特定途径的药物至关重要。总之，术语heteroduplex涵盖了分子生物学的基本方面，强调了遗传变异和相互作用的重要性。随着研究的进展，heteroduplex研究的意义将继续在遗传学、生物技术和医学中发挥关键作用。掌握这一概念不仅增强了我们对遗传机制的理解，还为健康相关挑战提供了创新解决方案。因此，探索heteroduplex结构及其功能仍然是生物研究中一个令人兴奋的前沿，承诺为科学和技术带来新的见解和进展。