griseofulvin

简明释义

英[ˌɡrɪzɪəʊˈfʊlvɪn]美[ˈɡrɪziəˌfʌlvɪn]

n. [药] 灰黄霉素

英英释义

单词用法

同义词

反义词

例句

1.The solubility of griseofulvin in supercritical CO2 with cosolvent acetone at different temperature, pressure and concentration was measured in this study.

动态法测定了灰黄霉素在不同的操作温度、压力以及共溶剂丙酮浓度下在超临界CO2中的溶解度。

2.Objective To compare the efficacy of terbinafine with itraconazole, fluconazole and griseofulvin in the treatment of dermatophyte onychomycosis.

目的比较特比萘芬与伊曲康唑、氟康唑、灰黄霉素治疗甲癣疗效的差异。

3.Food may enhance the extent of absorption for poorly soluble drugs (eg, griseofulvin), reduce it for drugs degraded in the stomach (eg, penicillin g), or have little or no effect.

食物可增强某些溶解性差的药物(如灰黄霉素)的吸收，减少胃内降解药物(如青霉素g)的吸收，食物以裁缝折吸收或无影响，或影响甚少。

4.Food may enhance the extent of absorption for poorly soluble drugs (eg, griseofulvin), reduce it for drugs degraded in the stomach (eg, penicillin g), or have little or no effect.

食物可增强某些溶解性差的药物(如灰黄霉素)的吸收，减少胃内降解药物(如青霉素g)的吸收，食物以裁缝折吸收或无影响，或影响甚少。

5.More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy.

近来，灰黄霉素成为青霉属分类学中的一个重要的表型标志物。

6.Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans.

灰黄霉素是一种选择性的抗真菌剂用于治疗动物和人类的皮肤感染。

7.There are many reports that griseofulvin is the first choice for kerion, but it can hardly be used in children for its hepatic toxicity.

很多文献报道，灰黄霉素治疗脓癣仍是首选药物，但由于该药的肝脏毒性大，因此目前较少应用于儿童脓癣的治疗。

8.The strongest drug resistance was griseofulvin, which reached up to 86.6%, followed by fluconazole (19.2%) and itraconazole (10.6 %).

耐药性最强的是灰黄霉素，耐药率达86.6%，其次为氟康唑、伊曲康唑，耐药率分别是19.2%、10.6%。

9.My friend used griseofulvin to treat his athlete's foot effectively.

我的朋友有效地使用灰黄霉素治疗了他的脚气。

10.It is important to take griseofulvin with food to enhance absorption.

重要的是要与食物一起服用灰黄霉素以增强吸收。

11.The side effects of griseofulvin can include nausea and dizziness.

服用灰黄霉素的副作用可能包括恶心和头晕。

12.The doctor prescribed griseofulvin for my fungal infection.

医生给我开了灰黄霉素治疗我的真菌感染。

13.After taking griseofulvin, I noticed a significant improvement in my skin condition.

服用灰黄霉素后，我注意到我的皮肤状况有了显著改善。

作文

Griseofulvin is an antifungal medication that has been used for decades to treat various fungal infections, particularly those affecting the skin, hair, and nails. This compound works by inhibiting the growth of fungi, thereby allowing the body's immune system to combat the infection more effectively. The use of griseofulvin has become a cornerstone in dermatological treatments, especially for conditions such as tinea capitis, which is a fungal infection of the scalp commonly seen in children. The history of griseofulvin dates back to its discovery in the 1930s, when it was first isolated from the Penicillium griseofulvum mold. Since then, it has undergone numerous studies and clinical trials to establish its efficacy and safety profile. One of the key advantages of griseofulvin is its ability to target the fungal cell's microtubules, disrupting their function and preventing cell division. This mechanism of action makes it particularly effective against dermatophytes, which are fungi that require keratin for growth. Patients typically take griseofulvin orally for several weeks or months, depending on the severity of the infection. It is essential to follow the prescribed dosage carefully, as improper use can lead to treatment failure or recurrence of the infection. Common side effects include gastrointestinal disturbances, headaches, and allergic reactions, although serious side effects are rare. Moreover, the effectiveness of griseofulvin can be influenced by various factors, including the patient's overall health, the specific type of fungus involved, and whether the patient is taking other medications that might interact with griseofulvin. For instance, some drugs can increase or decrease the metabolism of griseofulvin, altering its concentration in the body and potentially affecting its therapeutic efficacy. In recent years, there has been a growing concern regarding antifungal resistance, similar to what has been observed with antibiotics. While griseofulvin remains effective against many strains of fungi, there are reports of reduced sensitivity in certain cases. This highlights the importance of using antifungal medications judiciously and only when necessary. In conclusion, griseofulvin is a vital tool in the fight against fungal infections, particularly in dermatology. Its discovery and development have significantly improved the quality of life for many patients suffering from persistent and often distressing fungal conditions. As with any medication, understanding how griseofulvin works, its potential side effects, and the importance of proper usage can empower patients to make informed decisions about their treatment options. Continued research into antifungal agents, including griseofulvin, is essential to ensure effective management of fungal infections in the future.

格列美脲是一种抗真菌药物，几十年来一直用于治疗各种真菌感染，特别是影响皮肤、头发和指甲的感染。这种化合物通过抑制真菌的生长，从而使身体的免疫系统能够更有效地对抗感染。griseofulvin的使用已成为皮肤科治疗的基石，特别是对于像头癣这样的情况，这是一种常见于儿童的头皮真菌感染。griseofulvin的历史可以追溯到20世纪30年代，当时它首次从青霉菌（Penicillium griseofulvum）中分离出来。从那时起，它经历了无数研究和临床试验，以确定其疗效和安全性。griseofulvin的一个关键优势是能够靶向真菌细胞的微管，干扰其功能并阻止细胞分裂。这种作用机制使其在对抗需要角蛋白生长的皮肤癣菌方面特别有效。患者通常口服griseofulvin数周或数月，具体取决于感染的严重程度。遵循处方剂量非常重要，因为不当使用可能导致治疗失败或感染复发。常见副作用包括胃肠道不适、头痛和过敏反应，尽管严重副作用很少见。此外，griseofulvin的有效性可能受到多种因素的影响，包括患者的整体健康状况、涉及的特定真菌类型以及患者是否服用可能与griseofulvin相互作用的其他药物。例如，一些药物可以增加或减少griseofulvin的代谢，改变其在体内的浓度，并可能影响其治疗效果。近年来，关于抗真菌耐药性的担忧日益增加，类似于抗生素所观察到的情况。虽然griseofulvin对许多真菌株仍然有效，但有报道称某些情况下敏感性降低。这突显了合理使用抗真菌药物的重要性，仅在必要时使用。总之，griseofulvin是对抗真菌感染的重要工具，特别是在皮肤科。它的发现和发展显著改善了许多患有持久且常常令人苦恼的真菌病患者的生活质量。了解griseofulvin的工作原理、潜在副作用以及正确使用的重要性，可以使患者在选择治疗方案时做出明智的决定。对抗真菌药物的持续研究，包括griseofulvin，对于确保未来有效管理真菌感染至关重要。