allostery

简明释义

英[/əˈlɑːstəri/]美[/əˈlɑːstəri/]

n. 变构状态；变构效应

英英释义

单词用法

同义词

反义词

例句

1.Dynamic allostery governs cyclophilin A-HIV capsid interplay.

动态异构控制a - hiv衣壳相互亲。

2.Dynamic allostery governs cyclophilin A-HIV capsid interplay.

动态异构控制a - hiv衣壳相互亲。

3.Researchers found that allostery can enhance the binding affinity of proteins to their substrates.

研究人员发现，变构调节可以增强蛋白质与其底物的结合亲和力。

4.The concept of allostery is crucial in understanding how enzymes regulate biochemical pathways.

理解酶如何调节生化途径的关键在于变构调节的概念。

5.Understanding allostery is key for drug design, as it can lead to more effective therapeutics.

理解变构调节对于药物设计至关重要，因为它可以导致更有效的治疗方法。

6.The study of allostery has revealed new targets for cancer treatment.

对变构调节的研究揭示了癌症治疗的新靶点。

7.The mechanism of allostery allows a single molecule to influence the activity of an entire protein complex.

通过变构调节机制，单个分子可以影响整个蛋白质复合体的活性。

作文

Allostery is a fascinating concept in biochemistry that describes how the function of a protein can be regulated by the binding of a molecule at a site other than its active site. This phenomenon is crucial for understanding how enzymes and receptors work, as it allows for a more nuanced control of biological processes. The term 'allostery' comes from the Greek words 'allo,' meaning 'other,' and 'stereos,' meaning 'solid' or 'shape.' Essentially, allostery refers to the change in the shape of a protein that occurs when a regulatory molecule binds to it, leading to an increase or decrease in its activity.One of the most well-known examples of allostery (变构调节) is the regulation of hemoglobin, the protein responsible for transporting oxygen in the blood. Hemoglobin has multiple binding sites for oxygen, and its ability to pick up and release oxygen is influenced by the presence of other molecules, such as carbon dioxide and protons. When carbon dioxide levels rise in the blood, it triggers a conformational change in hemoglobin that reduces its affinity for oxygen. This allows hemoglobin to release oxygen more readily in tissues where it is needed most, demonstrating the importance of allostery (变构调节) in physiological processes.In addition to hemoglobin, many enzymes exhibit allostery (变构调节), which is vital for metabolic pathways. For instance, an enzyme might have an active site where substrate molecules bind, but it may also have allosteric sites where other molecules can bind. These allosteric effectors can either enhance or inhibit the enzyme's activity, allowing cells to respond rapidly to changes in their environment. This regulation is essential for maintaining homeostasis and ensuring that metabolic processes occur efficiently.The study of allostery (变构调节) has significant implications for drug development as well. Many pharmaceutical compounds are designed to target allosteric sites on proteins, rather than the active sites. This approach can lead to drugs that have fewer side effects and more specific actions, as they can modulate protein function without completely inhibiting it. For example, allosteric modulators are being explored for their potential in treating conditions like cancer, diabetes, and neurological disorders.Moreover, understanding allostery (变构调节) can help researchers design better therapeutic strategies. By knowing how various molecules interact with proteins, scientists can predict how changes in these interactions might affect cellular functions. This knowledge is particularly important in the context of personalized medicine, where treatments can be tailored to individual patients based on their unique biochemical profiles.In conclusion, allostery (变构调节) is a key concept that underpins many aspects of biochemistry and molecular biology. It highlights the intricate ways in which proteins can be regulated and the importance of this regulation in maintaining life. As research continues to uncover the complexities of allosteric interactions, we can expect to see advancements in both our understanding of biology and the development of novel therapeutic approaches.