hyperalgesia

简明释义

英[ˌhaɪpərælˈdʒiːzɪə]美[ˌhaɪpərælˈdʒiːzɪə]

n. [医] 痛觉过敏

英英释义

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例句

1.BACKGROUND: Chronic pain, including hyperalgesia and algesthesia paresthesia, is pathological phenomenons making the patients felt unendurable and lacking of clinical treatments.

背景：慢性痛包括痛觉过敏和痛觉感觉异常，是患者感到难以忍受和临床缺乏治疗手段的一种病理现象。

2.Results Sprout number of DRG in experimental group rats decreased obviously and the symptom of hyperalgesia was improved as compared to control rats.

结果实验组大鼠drg内交感芽生明显减少，热痛过敏症状被抑制。

3.RESULTS: Thermal hyperalgesia developed between Days 12 and 18 after cancer cell inoculation.

结果：热痛觉过敏在肿瘤细胞植入后的12- 18天发生进展。

4.Pain and hyperalgesia was caused by injury of tissue and peripheral nerves.

组织损伤及外周神经损伤后可导致痛及痛过敏。

5.Many studies in recent years indicated that the activation and translocation of protein kinase C (PKC) of neurons in the dorsal horn of spinal cord was related with hyperalgesia.

但其详细机制并未完全阐明。近年来研究表明，脊髓后角神经元内蛋白激酶C（PKC）的激活和位移与痛感觉及痛过敏的形成有关。

6.NGF levels are increased in inflammatory processes and administration of exogenous NGF leads to hyperalgesia, hypersensitivity to thermal stimulation and muscular pain.

神经生长因子水平炎症过程中的神经生长因子增加外源性和管理导致痛觉过敏，过敏热刺激和肌肉痛。

7.Conclusion Intrathecal FC can reduce the mechanical and heat hyperalgesia in mice with bone cancer pain, and the astrocytes may play a role in the nociceptive transmission at the spinal level.

结论鞘内注射氟代柠檬酸能明显减轻骨癌痛小鼠机械痛敏和热痛敏，提示星形胶质细胞在脊髓水平参与疼痛信息传递。

8.Patients with chronic pain may experience hyperalgesia, which means they are more sensitive to pain than normal.

慢性疼痛患者可能会经历超敏痛，这意味着他们对疼痛的敏感度高于正常水平。

9.Understanding hyperalgesia is crucial for effective pain management.

理解超敏痛对于有效的疼痛管理至关重要。

10.The doctor explained that hyperalgesia can occur as a result of nerve damage.

医生解释说，超敏痛可能是神经损伤的结果。

11.After the surgery, she developed hyperalgesia, making even light touches feel painful.

手术后，她出现了超敏痛，甚至轻微的触碰也会感到疼痛。

12.In some cases, hyperalgesia can be a side effect of certain medications.

在某些情况下，超敏痛可能是某些药物的副作用。

作文

Pain is a complex and subjective experience that can significantly affect an individual's quality of life. One of the more intriguing phenomena related to pain is known as hyperalgesia, which refers to an increased sensitivity to painful stimuli. This condition can occur in various contexts, including after injury, surgery, or even in chronic pain conditions such as fibromyalgia. Understanding hyperalgesia is essential for both medical professionals and patients, as it can influence treatment strategies and pain management techniques.The mechanisms behind hyperalgesia are multifaceted. When tissue is damaged, the body responds by releasing inflammatory mediators that sensitize nociceptors, the sensory receptors responsible for detecting pain. This sensitization can lead to a state where normal stimuli, which would not typically cause pain, become painful. For instance, a light touch on a bruised area may elicit significant discomfort due to hyperalgesia. There are two primary types of hyperalgesia: primary and secondary. Primary hyperalgesia occurs at the site of injury, where the nociceptors become sensitized. Secondary hyperalgesia, on the other hand, involves changes in the central nervous system, leading to increased pain sensitivity in areas surrounding the injury. This phenomenon illustrates how pain perception is not solely a localized response but involves complex interactions within the nervous system.The implications of hyperalgesia extend beyond the individual experience of pain. In clinical settings, recognizing and addressing hyperalgesia can be vital for effective pain management. For example, patients recovering from surgery may experience hyperalgesia in the postoperative area, complicating their recovery process. Pain management strategies may need to be adjusted to account for this heightened sensitivity, potentially involving the use of analgesics, physical therapy, and psychological support.Moreover, understanding hyperalgesia can help in the development of new therapeutic approaches. Research into the underlying mechanisms of hyperalgesia has led to the exploration of novel medications that target specific pathways involved in pain processing. By addressing the root causes of hyperalgesia, healthcare providers can offer more effective treatments that can improve patient outcomes.In conclusion, hyperalgesia represents a significant aspect of pain perception that merits attention from both healthcare professionals and patients alike. Recognizing the increased sensitivity to pain associated with hyperalgesia can lead to better pain management strategies and improved quality of life for those affected. As research continues to advance our understanding of pain mechanisms, it is crucial to incorporate this knowledge into clinical practice to enhance patient care and treatment efficacy.

疼痛是一种复杂且主观的体验，可能会显著影响个体的生活质量。与疼痛相关的一个更有趣的现象被称为超敏痛，指的是对痛觉刺激的敏感性增加。这种情况可以在多种情况下发生，包括受伤、手术后，甚至在慢性疼痛状况如纤维肌痛中。理解超敏痛对医学专业人士和患者而言至关重要，因为它会影响治疗策略和疼痛管理技术。超敏痛背后的机制是多方面的。当组织受损时，身体会通过释放炎症介质来响应，这些介质使痛觉感受器变得敏感。这种敏感化可能导致一种状态，在这种状态下，正常刺激（通常不会引起疼痛）变得疼痛。例如，轻触淤伤区域可能会因为超敏痛而引发显著的不适。超敏痛有两种主要类型：原发性和继发性。原发性超敏痛发生在受伤部位，那里痛觉感受器变得敏感。而继发性超敏痛则涉及中枢神经系统的变化，导致受伤周围区域的疼痛敏感性增加。这一现象说明了疼痛感知不仅仅是局部反应，而是涉及神经系统内复杂的相互作用。超敏痛的影响超出了个体疼痛体验。在临床环境中，识别和处理超敏痛对于有效的疼痛管理至关重要。例如，手术恢复的患者可能会在术后区域经历超敏痛，这会使他们的恢复过程变得复杂。疼痛管理策略可能需要调整，以考虑这种高度敏感性，可能涉及使用镇痛药、物理治疗和心理支持。此外，理解超敏痛有助于新疗法的发展。对超敏痛潜在机制的研究促使探索针对疼痛处理特定途径的新药物。通过解决超敏痛的根本原因，医疗服务提供者可以提供更有效的治疗，从而改善患者的结果。总之，超敏痛代表了疼痛感知的重要方面，值得医疗专业人士和患者的关注。认识到与超敏痛相关的疼痛敏感性增加，可以导致更好的疼痛管理策略和提高受影响者的生活质量。随着研究不断推进我们对疼痛机制的理解，将这些知识纳入临床实践以增强患者护理和治疗效果至关重要。