preclinical

简明释义

英[priːˈklɪnɪk(ə)l]美[priːˈklɪnɪkl]

adj. 临床前的；现出症状之前的潜伏期的

英英释义

单词用法

同义词

反义词

例句

1.The next likely step will be to open clinical trials for people with MPD as soon as 2009 once formal preclinical toxicology studies are completed.

下一步可能的工作：一旦该药物的正式的临床前毒理学试验完成，最快在2009年，开始针对MPD患者进行临床试验。

2.We have developed and characterized a preclinical model for the evaluation of immune-mediated metastatic breast cancer therapies.

我们开发并描述了一个临床前的模型，用来评估免疫介导转移性乳腺癌疗法。

3.Antisense Morpholino oligos have shown promise in preclinical studies however, they were found to cause a limited viral load reduction.

反义的吗啉寡展示了临诊前期的研究的前景，然而，它们被发现能引起一个有限的病毒载量减少。

4.Adjuvant safety and the use of preclinical models to assess adjuvant safety were due to be discussed at the WHO conference on adjuvants on 4-8 December 2005.

关于佐剂安全性以及利用临床前期模型评估佐剂安全性的问题已按期在2005年12月4 - 8日举行的WHO佐剂研讨会上进行讨论。

5.New candidate drug molecules that are advanced into preclinical testing by the research arm of a drug discovery company or organization.

药物开发公司或团体引入临床前检测的新的待选药物分子。

6.Clinical process divides typical armour hepatitis a phase: is preclinical, prodrome period, is icteric period, convalescence.

典型的甲型肝炎临床过程分四个阶段：潜伏期，前驱症状期，黄疸期，恢复期。

7.Researchers are conducting preclinical 临床前 studies to evaluate the safety of the vaccine.

研究人员正在进行临床前研究，以评估疫苗的安全性。

8.The findings from the preclinical 临床前 trials will guide the next steps in human testing.

来自临床前试验的发现将指导下一步的人体测试。

9.The company announced promising results from its preclinical 临床前 studies on cancer treatment.

该公司宣布其癌症治疗的临床前研究结果令人鼓舞。

10.The new drug is currently in the preclinical 临床前 phase of testing.

这款新药目前处于临床前测试阶段。

11.Before starting human trials, all compounds must go through preclinical 临床前 evaluation.

在开始人体试验之前，所有化合物必须经过临床前评估。

作文

In the field of medical research, the term preclinical refers to the stage of research that occurs before the clinical trials involving human subjects. This phase is critical because it lays the groundwork for understanding how a new drug or treatment might work in humans. During the preclinical phase, researchers conduct various studies using cell cultures and animal models to assess the safety and efficacy of the proposed treatment. These studies help identify potential side effects and determine the appropriate dosages. The preclinical research phase is essential for several reasons. First, it allows scientists to gather preliminary data that can predict how a drug will behave in the human body. This information is crucial for designing clinical trials that are both safe and effective. Without thorough preclinical testing, there is a higher risk of adverse effects during human trials, which can lead to severe consequences for participants and may halt the development of promising therapies.Moreover, the preclinical stage provides an opportunity to explore different formulations and delivery methods for a drug. For instance, researchers might investigate whether a drug is more effective when delivered as a pill, injection, or through another method. This exploration can significantly impact the overall effectiveness of the treatment once it reaches the clinical trial phase.Another important aspect of preclinical research is the assessment of pharmacokinetics and pharmacodynamics. Pharmacokinetics studies how the body absorbs, distributes, metabolizes, and excretes a drug, while pharmacodynamics examines the drug's biological effects on the body. Understanding these factors during the preclinical phase helps researchers predict how the drug will interact with human physiology, which is vital for ensuring its safety and efficacy.Furthermore, ethical considerations are paramount in preclinical research. Researchers must adhere to strict guidelines to ensure the humane treatment of animals used in studies. This includes providing adequate living conditions, minimizing pain and distress, and using alternatives whenever possible. The ethical implications of preclinical research have led to significant advancements in techniques that reduce the number of animals needed for testing, such as in vitro methods and computer modeling.In conclusion, the preclinical phase of medical research is a foundational step that determines the success of future clinical trials. It is a complex process that requires careful planning, ethical considerations, and rigorous scientific methods. By investing time and resources into preclinical studies, researchers can better ensure that the treatments they develop are safe and effective for human use. As we continue to advance in medical science, the importance of preclinical research cannot be overstated, as it ultimately shapes the future of healthcare and patient outcomes.

在医学研究领域，术语preclinical指的是发生在涉及人类受试者的临床试验之前的研究阶段。这个阶段至关重要，因为它为理解新药物或治疗在人体内可能的作用奠定了基础。在preclinical阶段，研究人员使用细胞培养和动物模型进行各种研究，以评估拟议治疗的安全性和有效性。这些研究有助于识别潜在的副作用并确定适当的剂量。preclinical研究阶段对于多个原因至关重要。首先，它允许科学家收集预测药物在人体内行为的初步数据。这些信息对于设计既安全又有效的临床试验至关重要。如果没有彻底的preclinical测试，人类试验中出现不良反应的风险就会增加，这可能导致参与者的严重后果，并可能停止有前景的疗法的发展。此外，preclinical阶段提供了探索药物不同配方和给药方法的机会。例如，研究人员可能会调查药物通过药丸、注射或其他方法给药时是否更有效。这种探索可以显著影响治疗在进入临床试验阶段后的整体效果。preclinical研究的另一个重要方面是药代动力学和药效学的评估。药代动力学研究药物在体内的吸收、分布、代谢和排泄，而药效学则检查药物对身体的生物学效应。在preclinical阶段了解这些因素有助于研究人员预测药物与人体生理的相互作用，这对于确保其安全性和有效性至关重要。此外，伦理考虑在preclinical研究中至关重要。研究人员必须遵循严格的指南，以确保对用于研究的动物进行人道对待。这包括提供适当的生活条件、最小化痛苦和压力，并在可能的情况下使用替代方法。preclinical研究的伦理影响促使了减少测试所需动物数量的技术的重大进展，例如体外方法和计算机建模。总之，医学研究的preclinical阶段是决定未来临床试验成功的基础步骤。这是一个复杂的过程，需要仔细的计划、伦理考虑和严格的科学方法。通过在preclinical研究中投入时间和资源，研究人员可以更好地确保他们开发的治疗方案对人类使用是安全和有效的。随着我们在医学科学中的不断进步，preclinical研究的重要性不容忽视，因为它最终塑造了医疗保健和患者结果的未来。