chemokine
简明释义
n. 趋化因子
英英释义
单词用法
化学趋化因子受体 | |
化学趋化因子信号传导 | |
促炎性化学趋化因子 | |
化学趋化因子梯度 |
同义词
反义词
例句
1.It has been proved that chemokine receptor antagonists have ideal curative effects on the diseases related to chemokines, and some drugs have entered the clinical tests.
许多研究表明：趋化因子受体拮抗剂对各种与趋化因子相关的疾病具有较好的疗效，有些药物已经进入临床试验中。
2.In inflammation responses, differentiation of t helper cells and gene expression of cytokine and chemokine are all regulated by epigenetics.
炎症反应中t辅助细胞的分化，细胞因子、趋化因子等基因的表达都受到表观遗传的调控。
3.Chemokine CCL21 is a ligand of chemokine receptor (CCR) 7.
趋化因子CCL21是趋化因子受体(CCR)7的一个配体。
4.Bronchoalveolar lavage fluid was assessed for total and differential cell counts, and cytokine and chemokine levels.
收集支气管肺泡灌洗液，评价总细胞和不同细胞计数、细胞因子和趋化因子水平。
5.The expression of chemokine receptors, the chemotactic capacities, and adhesion molecule expression was modulated by withdrawal of IL 2 and IL 4 from the culture medium.
在体外培养基中，趋化因子受体的表达即趋化运动的能力和粘附分子的表达受IL2和IL4的调节。
6.The research progress of HIV-1 and chemokine receptor was introduced in the …
本文就HIV-1与趋化因子受体的研究进展情况作一综述。
7.Chemokine receptors may become the hopeful targets in tumor therapy and have merits of prognosis because of their critical roles in tumor metastasis to specific organs.
由于其在肿瘤细胞器官选择性转移中的重要作用，趋化因子受体有希望成为肿瘤治疗的靶标并具有预后价值。
8.None of the cloned cells were keratin negative. The double time and IL-6 as well as chemokine production varies among different clones.
检测了细胞倍增时间和IL - 6、趋化因子等细胞因子，从倍增时间和因子产生能力看，各克隆差异很大。
9.Certain diseases can alter the production of chemokine in the body.
某些疾病可以改变体内化学趋化因子的产生。
10.Researchers are studying how different chemokine levels affect inflammation.
研究人员正在研究不同的化学趋化因子水平如何影响炎症。
11.The release of chemokine can attract immune cells to the site of infection.
释放的化学趋化因子可以吸引免疫细胞到感染部位。
12.The interaction between chemokine and its receptor is crucial for immune response.
化学趋化因子与其受体之间的相互作用对免疫反应至关重要。
13.Therapeutics targeting chemokine pathways may offer new treatment options.
针对化学趋化因子通路的治疗方法可能提供新的治疗选择。
作文
Chemokines are a fascinating class of signaling proteins that play a crucial role in the immune response. They are small cytokines, or proteins secreted by cells, that direct the movement of immune cells towards sites of inflammation, infection, or injury. The term 'chemokine' is derived from the words 'chemo' meaning chemical and 'kine' meaning movement. This highlights their primary function: to guide the migration of leukocytes, which are white blood cells essential for the body’s defense mechanisms. When an infection occurs, the body’s immune system is activated, and various immune cells are recruited to the site of infection. This recruitment is orchestrated by chemokines (化学趋化因子), which are produced by various types of cells, including macrophages, endothelial cells, and fibroblasts. The release of chemokines (化学趋化因子) creates a chemical gradient that immune cells can detect. As these cells move toward higher concentrations of chemokines (化学趋化因子), they effectively home in on the area where their action is needed most.There are several families of chemokines (化学趋化因子), categorized based on their structure and the receptors they bind to. The two main classes are CC-chemokines (化学趋化因子) and CXC-chemokines (化学趋化因子), which differ in the arrangement of cysteine residues in their protein structure. Each chemokine (化学趋化因子) has specific receptors on the surface of target cells, allowing for precise communication and response during immune reactions. For example, the chemokine (化学趋化因子) IL-8 primarily attracts neutrophils, while other chemokines (化学趋化因子) may attract different types of leukocytes like T cells or monocytes.The role of chemokines (化学趋化因子) extends beyond just directing immune cells. They are also involved in various physiological processes, such as tissue repair and development. Understanding how chemokines (化学趋化因子) function can provide insights into not only normal immune responses but also pathological conditions. For instance, chronic inflammation and autoimmune diseases often involve dysregulation of chemokines (化学趋化因子), leading to an inappropriate accumulation of immune cells in certain tissues.Moreover, chemokines (化学趋化因子) have been implicated in tumor biology. Tumors can exploit chemokines (化学趋化因子) to create an environment conducive to their growth and spread. By understanding these mechanisms, researchers are exploring therapeutic strategies that target chemokines (化学趋化因子) or their receptors to improve cancer treatment outcomes.In conclusion, chemokines (化学趋化因子) are vital components of the immune system, mediating the movement and function of immune cells. Their ability to guide cell migration makes them essential for effective immune responses against infections and injuries. Additionally, their involvement in disease processes highlights the importance of studying chemokines (化学趋化因子) for developing new therapeutic approaches. As research continues to uncover the complexities of chemokines (化学趋化因子) and their roles in health and disease, they remain a key focus in immunology and therapeutic development.
化学趋化因子是一类引人入胜的信号蛋白，在免疫反应中发挥着至关重要的作用。它们是小型细胞因子，或由细胞分泌的蛋白质，能够引导免疫细胞向炎症、感染或损伤的部位移动。“化学趋化因子”一词源自“化学”（chemo）和“运动”（kine）两个词。这突出了它们的主要功能：指导白血球（免疫细胞）迁移，白血球是身体防御机制所必需的。当发生感染时，身体的免疫系统被激活，各种免疫细胞被招募到感染部位。这种招募是由化学趋化因子（chemokines）调控的，后者由多种类型的细胞产生，包括巨噬细胞、内皮细胞和成纤维细胞。化学趋化因子（chemokines）的释放会产生一个化学梯度，免疫细胞可以检测到。随着这些细胞朝着化学趋化因子（chemokines）浓度较高的地方移动，它们有效地定位到其作用最需要的区域。化学趋化因子（chemokines）有几个家族，依据其结构和结合的受体进行分类。两个主要类别是CC-化学趋化因子（chemokines）和CXC-化学趋化因子（chemokines），它们在蛋白质结构中的半胱氨酸残基排列上有所不同。每种化学趋化因子（chemokines）在目标细胞表面都有特定的受体，从而实现免疫反应期间的精确通信和反应。例如，化学趋化因子（chemokines）IL-8主要吸引中性粒细胞，而其他化学趋化因子（chemokines）可能吸引不同类型的白血球，如T细胞或单核细胞。化学趋化因子（chemokines）的作用不仅限于指引免疫细胞。它们还参与各种生理过程，如组织修复和发育。理解化学趋化因子（chemokines）的功能可以提供对正常免疫反应以及病理状态的深入见解。例如，慢性炎症和自身免疫疾病通常涉及化学趋化因子（chemokines）的失调，导致某些组织中免疫细胞的不适当积聚。此外，化学趋化因子（chemokines）与肿瘤生物学也有关联。肿瘤可以利用化学趋化因子（chemokines）创造有利于其生长和扩散的环境。通过理解这些机制，研究人员正在探索针对化学趋化因子（chemokines）或其受体的治疗策略，以改善癌症治疗的结果。总之，化学趋化因子（chemokines）是免疫系统的重要组成部分，介导免疫细胞的运动和功能。它们引导细胞迁移的能力使其对有效的免疫反应至关重要，尤其是在对抗感染和损伤时。此外，它们在疾病过程中的作用突显了研究化学趋化因子（chemokines）以开发新治疗方法的重要性。随着研究不断揭示化学趋化因子（chemokines）及其在健康和疾病中的复杂角色，它们仍然是免疫学和治疗开发的关键焦点。
