proteoglycans

简明释义

英[ˌprəʊtəʊˈɡlaɪkənz]美[ˌproʊtəˈɡlaɪkænz]

n. [生化]蛋白聚糖（proteoglycan 的复数）

英英释义

单词用法

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例句

1.Conclusion Finding a way to degrade chondroitin sulphate proteoglycans may promote regeneration of axons after spinal cord injury.

结论研究能有效抑制硫酸软骨素蛋白多糖的方法可能促进损伤后脊髓的再生。

2.Objective:To investigate the effects of chondroitinase ABC on chondroitin sulfate proteoglycans(CSPGs) and growth associated protein-43(GAP-43)after spinal cord injury in rats.

目的：探讨硫酸软骨素酶ABC对严重的大鼠脊髓损伤蛋白多糖及生长相关蛋白43（GAP-43）基因表达的影响。

3.Objective to introduce the research advances of chondroitin sulphate proteoglycans inhibitory role on injured spinal cord of rats.

目的综述硫酸软骨素蛋白多糖在脊髓损伤后修复中抑制作用的研究现状。

4.The ECM is a multifunctional complex of proteins and proteoglycans assembled in a highly organized manner that contributes to the structural integrity of cells and tissue within an organ system.

ECM是一种以高度组织有序的方式构建而成的蛋白和蛋白多糖的多功能复合体，有助于保持器官系统内细胞和组织结构的完整性。

5.These changes indicated the decrease of the proteoglycans and increase of collagen in the herniated discs which may be the potential causes for disc herniation.

提示退变椎间盘中蛋白多糖含量降低，组成改变及胶原蛋白的增加可能是诱发椎间盘突出症的物质基础。

6.The ECM is a multifunctional complex of proteins and proteoglycans assembled in a highly organized manner that contributes to the structural integrity of cells and tissue within an organ system.

ECM是一种以高度组织有序的方式构建而成的蛋白和蛋白多糖的多功能复合体，有助于保持器官系统内细胞和组织结构的完整性。

7.Their principle function is production of type III collagen, elastin, and proteoglycans of the extracellular matrix of the alveolar septa.

其主要的功能是产生II I型胶原，弹性蛋白和肺泡隔细胞外基质中的蛋白多糖。

8.As one of the members of heparan sulfate proteoglycans, Glypican-3 (GPC3) participates in the process of cell proliferation, differentiation, adhesion and migration.

磷脂酰肌醇蛋白聚糖3是硫酸乙酰肝素糖蛋白家族中的一员，它参与调控细胞增殖、分化、黏附和迁移等过程。

9.The extracellular matrix is rich in proteoglycans, which provide structural support to tissues.

细胞外基质富含蛋白聚糖，为组织提供结构支持。

10.Therapeutic strategies targeting proteoglycans may improve tissue repair.

针对蛋白聚糖的治疗策略可能改善组织修复。

11.Research shows that proteoglycans play a crucial role in cell signaling.

研究表明，蛋白聚糖在细胞信号传导中发挥着关键作用。

12.In cartilage, proteoglycans help retain water and maintain its elasticity.

在软骨中，蛋白聚糖有助于保持水分并维持其弹性。

13.The degradation of proteoglycans in the joint can lead to osteoarthritis.

关节中蛋白聚糖的降解可能导致骨关节炎。

作文

Proteoglycans are essential macromolecules found in various tissues throughout the body. They play a critical role in the extracellular matrix (ECM), which is a complex network that provides structural and biochemical support to surrounding cells. One of the most significant features of proteoglycans (蛋白聚糖) is their ability to bind water, which helps maintain hydration and turgor in tissues. This property is especially important in cartilage, where proteoglycans (蛋白聚糖) contribute to its resilience and ability to withstand compressive forces. In connective tissues, proteoglycans (蛋白聚糖) interact with collagen fibers, aiding in the organization and stability of the ECM. They consist of a core protein with one or more glycosaminoglycan (GAG) chains attached. These GAGs are long, unbranched polysaccharides that can attract and hold water molecules, which is vital for the mechanical properties of tissues. For instance, in articular cartilage, the major proteoglycan (蛋白聚糖) is aggrecan, which aggregates with hyaluronic acid to form large complexes that provide the cartilage with its unique ability to resist deformation under stress.Moreover, proteoglycans (蛋白聚糖) are involved in cell signaling and regulation. They can bind to growth factors and cytokines, modulating their availability and activity. For example, the interaction between proteoglycans (蛋白聚糖) and fibroblast growth factor (FGF) is crucial for cellular proliferation and differentiation. This highlights the multifunctional nature of proteoglycans (蛋白聚糖) beyond their structural roles.In addition to their presence in healthy tissues, proteoglycans (蛋白聚糖) also play a significant role in pathological conditions. Changes in the composition and structure of proteoglycans (蛋白聚糖) can lead to diseases such as osteoarthritis, where the degradation of aggrecan results in loss of cartilage integrity. Furthermore, certain cancers have been associated with altered proteoglycan (蛋白聚糖) expression, which can facilitate tumor progression and metastasis by influencing cell adhesion and migration.Research into proteoglycans (蛋白聚糖) has expanded our understanding of various biological processes and disease mechanisms. Scientists are exploring therapeutic strategies that target proteoglycans (蛋白聚糖) to treat conditions like arthritis and cancer. By manipulating the interactions between proteoglycans (蛋白聚糖) and other molecular players in the ECM, it may be possible to restore normal tissue function or inhibit disease progression.In conclusion, proteoglycans (蛋白聚糖) are vital components of the extracellular matrix that serve multiple roles in maintaining tissue structure, facilitating cell signaling, and contributing to disease mechanisms. Their unique properties and functions make them a significant focus of biomedical research, with potential implications for developing new therapies for a range of conditions. Understanding the intricate biology of proteoglycans (蛋白聚糖) will continue to be an important area of study in the fields of cell biology, biochemistry, and medicine.

蛋白聚糖是存在于全身各种组织中的重要大分子。它们在细胞外基质（ECM）中发挥着关键作用，ECM是一个复杂的网络，为周围细胞提供结构和生化支持。蛋白聚糖（proteoglycans）最显著的特点之一是其结合水的能力，这有助于维持组织的水合和膨胀。这一特性在软骨中特别重要，蛋白聚糖（proteoglycans）有助于其弹性和承受压缩力的能力。在结缔组织中，蛋白聚糖（proteoglycans）与胶原纤维相互作用，帮助组织ECM的结构和稳定性。它们由一个核心蛋白和一个或多个糖胺聚糖（GAG）链组成。这些GAG是长而无分支的多糖，可以吸引和保持水分子，这对组织的机械特性至关重要。例如，在关节软骨中，主要的蛋白聚糖（proteoglycans）是聚集素（aggrecan），它与透明质酸聚合形成大型复合物，使软骨具有独特的抵抗变形的能力。此外，蛋白聚糖（proteoglycans）还参与细胞信号传导和调节。它们可以结合生长因子和细胞因子，调节其可用性和活性。例如，蛋白聚糖（proteoglycans）与成纤维生长因子（FGF）之间的相互作用对细胞增殖和分化至关重要。这突显了蛋白聚糖（proteoglycans）超越其结构角色的多功能性。除了在健康组织中的存在，蛋白聚糖（proteoglycans）在病理条件中也发挥着重要作用。蛋白聚糖（proteoglycans）的组成和结构变化可能导致如骨关节炎等疾病，其中聚集素的降解导致软骨完整性的丧失。此外，某些癌症与蛋白聚糖（proteoglycans）表达的改变有关，这可能通过影响细胞粘附和迁移来促进肿瘤进展和转移。对蛋白聚糖（proteoglycans）的研究扩展了我们对各种生物过程和疾病机制的理解。科学家们正在探索针对蛋白聚糖（proteoglycans）的治疗策略，以治疗关节炎和癌症等疾病。通过操控蛋白聚糖（proteoglycans）与ECM中其他分子之间的相互作用，可能有可能恢复正常的组织功能或抑制疾病进展。总之，蛋白聚糖（proteoglycans）是细胞外基质的重要成分，具有多种维持组织结构、促进细胞信号传导和参与疾病机制的作用。它们独特的特性和功能使其成为生物医学研究的重要焦点，对开发一系列疾病的新疗法具有潜在意义。理解蛋白聚糖（proteoglycans）的复杂生物学将继续成为细胞生物学、生物化学和医学领域的重要研究方向。