ribozyme

简明释义

英[ˈraɪbəʊˌzaɪm]美[ˈraɪbəˌzaɪm]

n. 酶性核酸；核糖酶

英英释义

单词用法

同义词

反义词

例句

1.Conclusion Ribozyme targeting cyclin Dl may effectively inhibit cyclin D1 expression and activation in the HSC T6 cell line.

结论载体表达的特异性核酶能有效地抑制HSC的细胞周期蛋白d1的表达和激活。

2.To design HDV ribozyme for human telomerase RNA (hTR) component, and observe its inhibition for telomerase activity. Pseudoknotted g.

设计针对端粒酶的HDV核酶，观察其对端粒酶活性抑制。

3.A self cleaving ribozyme was comprised of a hammerhead ribozyme and its target sequence located the downstream of the hammerhead ribozyme.

在锤头型核酶下游增加一段核酶作用的靶序列，使之成为自切割的核酶。

4.To design HDV ribozyme for human telomerase RNA( hTR) component, and observe its inhibition for telomerase activity. Pseudoknotted g.

设计针对端粒酶的HDV核酶，观察其对端粒酶活性抑制。

5.Objective to detect the cleavage activity of Giardia Canis virus (GCV) transfer vector-mediated hammerhead ribozyme for KRR1 in vitro transcript.

目的检测犬贾第虫病毒介导的锤头状核酶对犬贾第虫滋养体核仁功能性蛋白krr1基因体外转录体切割效率。

6.AIM: To investigate the effects of transfected JWA ribozyme gene on phenotype and migration of human pulmonary artery smooth muscle cells (PASMCs).

目的：探讨JWA核酶基因转染对肺动脉平滑肌细胞表型及迁移的影响。

7.The CCR5 ribozyme molecule stops the patient's white blood cells producing CCR5, a protein that HIV USES to get into host cells.

这种CCR5核酶分子能中止了病人的白血细胞产生CCR5，后者是艾滋病毒用于进入宿主细胞的一种蛋白质。

8.Ribozyme is a kind of catalytic nucleic acid molecules.

核酶是一类具有催化功能的核酸分子。

9.The ideal ribozyme should satisfy with requires of highly catalytic efficiency, well specificity and stabilization.

理想的核酶应满足高效、特异、稳定的要求。

10.AIM: To investigate the effects of transfected JWA ribozyme gene on phenotype and migration of human pulmonary artery smooth muscle cells (PASMCs).

目的：探讨JWA核酶基因转染对肺动脉平滑肌细胞表型及迁移的影响。

11.Researchers are exploring how ribozymes can be used to develop new therapeutic strategies.

研究人员正在探索如何利用核酶开发新的治疗策略。

12.The discovery of ribozymes has revolutionized our understanding of RNA's role in biological processes.

对核酶的发现彻底改变了我们对RNA在生物过程中的作用的理解。

13.Some viruses utilize ribozymes to facilitate their replication process.

一些病毒利用核酶来促进它们的复制过程。

14.The role of ribozymes in gene regulation is a fascinating area of study.

在基因调控中，核酶的作用是一个引人入胜的研究领域。

15.In the lab, scientists successfully engineered a ribozyme that can catalyze specific chemical reactions.

在实验室中，科学家们成功地设计出一种可以催化特定化学反应的核酶。

作文

In the field of molecular biology, the discovery of ribozyme has revolutionized our understanding of the role of RNA in cellular processes. A ribozyme is a type of RNA molecule that can catalyze biochemical reactions, similar to the way enzymes, which are typically proteins, function. This remarkable property of ribozymes was first discovered in the early 1980s by Thomas Cech and Sidney Altman, who later received the Nobel Prize in Chemistry for their groundbreaking work. The significance of ribozymes lies not only in their ability to catalyze reactions but also in their implications for the origins of life on Earth.The concept of a ribozyme challenges the traditional view that only proteins can serve as enzymes. It suggests that RNA, which is often considered merely a messenger that conveys genetic information from DNA to proteins, can also perform catalytic functions. This dual role of RNA supports the 'RNA world hypothesis,' which posits that early life forms may have relied solely on RNA for both genetic information storage and catalysis before the evolution of DNA and proteins.One of the most studied examples of a ribozyme is the self-splicing intron found in certain genes. These ribozymes can catalyze their own excision from a precursor RNA molecule, demonstrating their ability to facilitate complex biochemical processes without the need for protein enzymes. This self-catalytic property raises intriguing questions about the evolution of life and the potential for RNA-based life forms.Furthermore, ribozymes have practical applications in biotechnology and medicine. Scientists have engineered synthetic ribozymes that can target specific RNA sequences, leading to innovative approaches for gene therapy. By designing ribozymes that can cleave or modify harmful RNA molecules, researchers aim to develop treatments for various diseases, including viral infections and genetic disorders.In addition to therapeutic applications, ribozymes are also valuable tools in molecular biology research. They can be used in the study of gene expression, RNA processing, and other fundamental biological processes. By utilizing ribozymes, scientists can gain insights into the mechanisms of RNA function and regulation, further enhancing our understanding of cellular biology.Despite their many advantages, the study of ribozymes is still a relatively young field, and there is much more to learn. Ongoing research aims to uncover new ribozyme types and their functions, as well as to explore their potential in synthetic biology. As we continue to unravel the mysteries of these fascinating molecules, it is clear that ribozymes hold great promise for advancing our knowledge of life at the molecular level.In conclusion, the discovery of ribozymes has opened up new avenues of research and has challenged our understanding of the molecular basis of life. Their ability to act as catalysts and their potential applications in medicine and biotechnology underscore the importance of these unique RNA molecules. As we delve deeper into the world of ribozymes, we may uncover even more profound insights into the nature of life itself and the intricate web of biochemical interactions that sustain it.

在分子生物学领域，ribozyme的发现彻底改变了我们对RNA在细胞过程中的作用的理解。ribozyme是一种能够催化生化反应的RNA分子，类似于酶（通常是蛋白质）的功能。ribozyme这一显著特性首次于20世纪80年代初由托马斯·切赫和西德尼·阿尔特曼发现，他们因开创性的工作而获得了诺贝尔化学奖。ribozyme的重要性不仅在于其催化反应的能力，还在于其对地球生命起源的启示。ribozyme的概念挑战了传统观点，即只有蛋白质可以作为酶。这表明RNA不仅仅是一个传递遗传信息的信使，它还可以执行催化功能。这种RNA的双重角色支持了“RNA世界假说”，该假说认为早期生命形式可能完全依赖RNA进行遗传信息存储和催化，而不需要DNA和蛋白质的进化。最常研究的ribozyme之一是某些基因中发现的自剪接内含子。这些ribozyme可以催化它们自己从前体RNA分子中切除，展示了它们在没有蛋白质酶的情况下促进复杂生化过程的能力。这种自催化特性引发了关于生命演化的有趣问题，以及RNA基础生命形式的潜力。此外，ribozyme在生物技术和医学中具有实际应用。科学家们已经设计出合成的ribozyme，可以靶向特定的RNA序列，从而为基因治疗提供创新的方法。通过设计可以切割或修改有害RNA分子的ribozyme，研究人员旨在开发针对各种疾病的治疗，包括病毒感染和遗传疾病。除了治疗应用，ribozyme在分子生物学研究中也是宝贵的工具。它们可以用于研究基因表达、RNA加工和其他基本生物过程。通过利用ribozyme，科学家们可以深入了解RNA功能和调控机制，进一步增强我们对细胞生物学的理解。尽管有许多优点，但ribozyme的研究仍然是一个相对年轻的领域，还有很多需要学习的内容。正在进行的研究旨在揭示新的ribozyme类型及其功能，并探索它们在合成生物学中的潜力。随着我们继续揭开这些迷人分子的神秘面纱，显然ribozyme在推动我们对生命分子层面知识的进步方面具有巨大潜力。总之，ribozyme的发现为研究开辟了新的途径，并挑战了我们对生命分子基础的理解。它们作为催化剂的能力以及在医学和生物技术中的潜在应用突显了这些独特RNA分子的意义。随着我们更深入地探索ribozyme的世界，我们可能会发现对生命本质及其维持的复杂生化相互作用的更深刻见解。