binding fraction

简明释义

敛集率;

英英释义

例句

1.The drug's efficacy is determined by its binding fraction, which indicates how much of the drug is bound to its target site.

药物的有效性取决于其结合分数，这表明药物有多少是与目标位点结合的。

2.To optimize the formulation, we need to measure the binding fraction of the active ingredient in the solution.

为了优化配方，我们需要测量溶液中活性成分的结合分数。

3.A higher binding fraction usually correlates with increased biological activity.

较高的结合分数通常与增加的生物活性相关。

4.The binding fraction of a substrate to an enzyme can significantly affect the reaction rate.

底物与酶的结合分数可以显著影响反应速率。

5.In protein studies, the binding fraction helps researchers understand the interaction between proteins and ligands.

在蛋白质研究中，结合分数帮助研究人员理解蛋白质与配体之间的相互作用。

作文

The concept of binding fraction is widely used in various scientific fields, particularly in biochemistry and pharmacology. It refers to the proportion of a substance that is bound to a target, such as a receptor or an enzyme, compared to the total amount of that substance present in a system. Understanding the binding fraction is crucial for determining the efficacy of drugs and their potential interactions within biological systems.In pharmacology, for instance, when a drug enters the bloodstream, it does not exist in isolation. Instead, it interacts with proteins and other molecules. The binding fraction tells researchers how much of the drug is actually available to exert its therapeutic effects. A high binding fraction indicates that most of the drug is bound to proteins, which may limit its availability to target cells. Conversely, a low binding fraction suggests that a significant portion of the drug is free and potentially active.To illustrate this further, consider a scenario where a new medication is being tested. Scientists measure the binding fraction of the drug to serum albumin, a major protein in blood. If the results show that 90% of the drug is bound to albumin, only 10% remains free to act on its intended target, such as a specific receptor on a cell. This information can significantly influence dosage recommendations and treatment plans.Moreover, the binding fraction can vary based on several factors, including the concentration of the drug, the presence of other substances, and the characteristics of the target. For example, some drugs may have a high binding fraction at lower concentrations but may exhibit different binding behavior at higher concentrations due to saturation effects. This variability emphasizes the importance of conducting thorough studies to understand how the binding fraction changes under different conditions.In addition to its implications in drug development, the binding fraction also plays a role in understanding disease mechanisms. In certain diseases, the binding properties of biomolecules can change, leading to altered binding fractions. For example, in cancer, changes in protein expression can affect how drugs bind to their targets, which may result in decreased efficacy or increased toxicity. By studying these changes, researchers can develop better-targeted therapies that take into account the altered binding fractions observed in diseased states.In summary, the binding fraction is a vital parameter in the fields of biochemistry and pharmacology. It provides insights into how substances interact within biological systems and helps guide the development of effective therapeutic strategies. As our understanding of the binding fraction deepens, we can expect advancements in drug design and personalized medicine, ultimately leading to better health outcomes for patients. Understanding the nuances of binding fraction not only enhances our knowledge of molecular interactions but also paves the way for innovative solutions in tackling complex health challenges.

“结合分数”这一概念广泛应用于多个科学领域，特别是生物化学和药理学。它指的是与目标（如受体或酶）结合的物质比例，与系统中存在的该物质总量相比。理解“结合分数”对于确定药物的有效性及其在生物系统内的潜在相互作用至关重要。例如，在药理学中，当药物进入血液时，它并不是孤立存在的。相反，它与蛋白质和其他分子相互作用。“结合分数”告诉研究人员有多少药物实际上可用于发挥其治疗效果。高“结合分数”表明大部分药物与蛋白质结合，这可能限制其对靶细胞的可用性。相反，低“结合分数”则表明相当大一部分药物是游离的，可能具有活性。为了进一步说明这一点，考虑一个新药物正在进行测试的场景。科学家测量药物与血清白蛋白（一种主要的血液蛋白）的“结合分数”。如果结果显示90%的药物与白蛋白结合，则只有10%保持游离状态，可以作用于其预期的靶标，例如细胞上的特定受体。这一信息可以显著影响剂量建议和治疗方案。此外，“结合分数”还可能根据多种因素而变化，包括药物浓度、其他物质的存在以及靶标的特征。例如，一些药物在较低浓度下可能具有高“结合分数”，但在较高浓度时由于饱和效应可能表现出不同的结合行为。这种变异性强调了进行全面研究以了解“结合分数”在不同条件下如何变化的重要性。除了在药物开发中的意义外，“结合分数”在理解疾病机制方面也起着重要作用。在某些疾病中，生物分子的结合特性可能会发生变化，从而导致“结合分数”的改变。例如，在癌症中，蛋白质表达的变化可能会影响药物与其靶标的结合，可能导致有效性降低或毒性增加。通过研究这些变化，研究人员可以开发更具针对性的疗法，考虑到在病态状态中观察到的改变的“结合分数”。总之，“结合分数”是生物化学和药理学领域的重要参数。它提供了关于物质在生物系统内如何相互作用的见解，并帮助指导有效治疗策略的开发。随着我们对“结合分数”的理解加深，我们可以期待药物设计和个性化医学的进步，最终为患者带来更好的健康结果。理解“结合分数”的细微差别不仅增强了我们对分子相互作用的认识，也为应对复杂健康挑战开辟了创新解决方案的道路。