desmosomes

简明释义

英[ˈdɛzməˌsoʊmz]美[ˈdɛzməˌsoʊmz]

n. 细胞桥粒（desmosome 的复数形式）

英英释义

单词用法

同义词

反义词

例句

1.The cells are pink and polygonal in shape with intercellular Bridges (seen as desmosomes or "tight junctions" by electron microscopy).

细胞呈粉红色、多边形，并可见细胞间桥(通过电镜看到的桥粒或紧密连接)。

2.The tonofilaments condense into bundles and become attached to desmosomes.

张力细丝集中成束，并附着于桥粒上。

3.The dentin side between the odontoblasts was connected by junctional complex and the other area was connected by the desmosomes.

相邻成牙本质细胞间的牙本质侧有连接复合体相连，其他区域则为桥粒。

4.The cells are pink and polygonal in shape with intercellular Bridges (seen as desmosomes or "tight junctions" by electron microscopy).

细胞呈粉红色、多边形，并可见细胞间桥(通过电镜看到的桥粒或紧密连接)。

5.In cardiac muscle, desmosomes (细胞间桥) help maintain tissue integrity during contractions.

在心脏肌肉中，desmosomes（细胞间桥）有助于在收缩期间维持组织的完整性。

6.The adhesion between epithelial cells is largely due to desmosomes (细胞间桥).

上皮细胞之间的粘附主要归功于desmosomes（细胞间桥）。

7.The structure of the skin is supported by strong connections called desmosomes (细胞间桥).

皮肤的结构由称为desmosomes（细胞间桥）的强连接支持。

8.Research indicates that mutations in genes responsible for desmosomes (细胞间桥) can lead to skin disorders.

研究表明，负责desmosomes（细胞间桥）的基因突变可能导致皮肤疾病。

9.During embryonic development, desmosomes (细胞间桥) play a crucial role in cell differentiation.

在胚胎发育过程中，desmosomes（细胞间桥）在细胞分化中发挥着关键作用。

作文

In the intricate world of cellular biology, understanding the components that make up our cells is crucial for grasping how organisms function. One such component, which plays a vital role in maintaining the structural integrity of tissues, is known as desmosomes. These specialized structures are essential for the adhesion between cells, especially in tissues that experience significant mechanical stress, such as the skin and cardiac muscle. Desmosomes are often described as 'spot welds' between adjacent cells, providing strength and stability to the tissue. The formation of desmosomes involves a complex interplay of proteins that link the cytoskeleton of one cell to that of another. Central to this structure are cadherins, which are transmembrane proteins that facilitate cell-cell adhesion. When these cadherins bind to each other across the intercellular space, they initiate a cascade of intracellular signaling that reinforces the connection between the two cells. This is particularly important in tissues that undergo frequent stretching or contracting, as it helps prevent the cells from pulling apart.Moreover, desmosomes are not only crucial for mechanical stability but also play a role in cellular communication. The connections formed by desmosomes can influence the behavior of neighboring cells, impacting processes such as cell growth and differentiation. For instance, in the heart, the integrity of desmosomes is vital for maintaining proper electrical conduction between cardiac cells, thereby ensuring coordinated contractions necessary for effective pumping of blood.However, when the function of desmosomes is compromised, it can lead to various diseases. Mutations in the genes encoding desmosomal proteins have been linked to skin disorders such as pemphigus vulgaris, where the immune system mistakenly attacks these structures, leading to blistering and loss of tissue integrity. Similarly, in the heart, defects in desmosomes can contribute to arrhythmogenic right ventricular cardiomyopathy (ARVC), a condition characterized by the replacement of heart muscle with fatty or fibrous tissue, increasing the risk of arrhythmias.Research into desmosomes continues to uncover their multifaceted roles in both normal physiology and disease states. Understanding how desmosomes function at a molecular level could pave the way for new therapeutic strategies aimed at restoring their function in various disorders. For example, targeting the signaling pathways associated with desmosomes might offer new avenues for treating conditions where cell adhesion is compromised.In conclusion, desmosomes are more than just simple adhesive structures; they are integral components of cellular architecture that ensure tissue integrity and function. By studying desmosomes, we gain insights not only into the basic principles of cell biology but also into the complexities of human health and disease. As we continue to unravel the mysteries of these remarkable structures, we move closer to understanding the fundamental processes that sustain life itself.

在细胞生物学的复杂世界中，理解构成我们细胞的成分对于掌握生物体的功能至关重要。其中一个组成部分，即在维持组织结构完整性方面发挥着重要作用的，被称为细胞间桥。这些特殊结构对细胞之间的粘附至关重要，尤其是在经历显著机械压力的组织中，如皮肤和心脏肌肉。细胞间桥通常被描述为相邻细胞之间的“点焊”，为组织提供了强度和稳定性。细胞间桥的形成涉及细胞骨架之间连接的复杂蛋白质相互作用。该结构的核心是钙黏附蛋白，这是一种跨膜蛋白，促进细胞-细胞粘附。当这些钙黏附蛋白在细胞间隙中相互结合时，它们会启动一系列细胞内信号传导，增强两个细胞之间的连接。这在经常拉伸或收缩的组织中尤为重要，因为它有助于防止细胞分开。此外，细胞间桥不仅对机械稳定性至关重要，还在细胞通信中发挥作用。由细胞间桥形成的连接可以影响邻近细胞的行为，影响细胞生长和分化等过程。例如，在心脏中，细胞间桥的完整性对于维持心肌细胞之间的电传导至关重要，从而确保有效的血液泵送所需的协调收缩。然而，当细胞间桥的功能受到损害时，可能会导致各种疾病。编码细胞间桥蛋白的基因突变已与皮肤病如天疱疮相关联，其中免疫系统错误地攻击这些结构，导致水泡和组织完整性的丧失。同样，在心脏中，细胞间桥的缺陷可能会导致右心室心肌病（ARVC），这种情况以心肌被脂肪或纤维组织替代为特征，增加了心律失常的风险。对细胞间桥的研究继续揭示其在正常生理和疾病状态中的多面角色。理解细胞间桥在分子水平上的功能可能为恢复其在各种疾病中的功能提供新的治疗策略。例如，靶向与细胞间桥相关的信号通路可能为治疗细胞粘附受损的疾病提供新的途径。总之，细胞间桥不仅仅是简单的粘附结构；它们是细胞结构的基本组成部分，确保组织的完整性和功能。通过研究细胞间桥，我们不仅获得了细胞生物学基本原理的见解，还深入了解了人类健康和疾病的复杂性。随着我们继续揭开这些非凡结构的神秘面纱，我们将更接近理解维持生命本身的基本过程。