proband

简明释义

英[ˈprəʊbænd]美[ˈproʊbænd]

n. （遗传疾病研究中家系的）渊源者

英英释义

单词用法

同义词

反义词

例句

1.Haplotype analysis indicated that the proband and her daughter Shared the same causative haplotype. Conclusion This is the first report of the phenotype and genotype of AD-EDMD in Chinese.

单倍型分析显示先证者及女儿具有相同的致病单倍型。结论报道了中国人常染色体显性遗传ed MD患者的表现型及基因型。

2.No antibody was found in both of these two proband 'sera.

两位先证者血清中均无抗体。

3.Carrier testing for at-risk family members may be available once the CBS mutations have been identified in the proband.

如果先证者的CBS突变被鉴定，也可能提供有风险的家族成员进行携带者检测。

4.The higher the extent of the relation to the proband is, the higher the prevalence is.

其亲属发病率高低与血缘关系近远相关，与先证者血缘关系越近的亲属患病率越高；

5.If the mother of the proband is a carrier, the chance of transmitting the disease-causing mutation in each pregnancy is 50%.

如果先证者的母亲是携带者，则每次怀孕传递致病突变的几率是50%。

6.Results a homozygous mutation at exon 13 of the proband was found by parallel TGGE. Homozygous and heterozygous mutations were also found in the family by parallel TGGE.

结果平行tgge发现，两患儿第13外显子存在一纯合突变，其父母此外显子存在杂合突变。

7.In contrast, direct DNA sequencing requires only a single sample from the proband.

相比之下，直接测序只需要被检测者的血样。

8.Methods: Thyroid hormone was detected in total 13 persons including the proband and his 12 relatives.

方法：调查包括先证者3代家系成员共计13人，检测血清甲状腺激素。

9.The risk to the sibs of a male proband depends upon the carrier status of the mother.

男性先证者的同胞的患病风险取决于其母亲的携带者状态。

10.The proband's blood samples were analyzed to identify any genetic mutations.

对proband 的血样进行了分析，以识别任何遗传突变。

11.In genetic studies, a proband is the individual being investigated for a particular trait or disorder.

在遗传研究中，proband 是被调查特定特征或疾病的个体。

12.In this case study, the proband exhibited symptoms that were consistent with the genetic disorder.

在这个案例研究中，proband 表现出的症状与遗传疾病相符。

13.The family history of the proband can provide valuable insights into hereditary conditions.

该proband 的家族史可以为遗传病提供宝贵的见解。

14.Researchers often collect data from the proband to understand the genetic basis of diseases.

研究人员通常从proband 收集数据，以了解疾病的遗传基础。

作文

In the field of genetics and epidemiology, the term proband is used to refer to an individual being studied or evaluated, particularly in relation to a specific genetic trait or condition. The importance of identifying a proband lies in its ability to provide insights into hereditary patterns and the potential risk factors associated with certain diseases. Understanding the role of a proband can also help researchers and healthcare professionals develop more effective strategies for diagnosis and treatment.When conducting family studies, researchers often begin by identifying a proband. This individual may be affected by a genetic disorder, and their family members are then assessed to determine whether the condition is inherited. For example, if a child is diagnosed with a rare genetic disease, that child becomes the proband in the study, and the parents and siblings will be evaluated to see if they carry the same genetic markers. This approach helps in understanding the inheritance patterns of the disease and can lead to better management plans for affected families.The concept of a proband is crucial not only for genetic research but also for public health initiatives. By studying probands and their families, scientists can identify potential environmental or lifestyle factors that might contribute to the development of certain conditions. For instance, if a proband has a history of heart disease, researchers might investigate dietary habits, exercise routines, and other lifestyle choices within the family to determine what influences the onset of the disease.Moreover, the identification of a proband can aid in genetic counseling. Genetic counselors use information obtained from probands to educate families about their risks for inherited conditions. They can provide guidance on screening options and preventive measures, which can be crucial for early intervention. For example, if a proband is found to have a mutation linked to breast cancer, family members can be tested for the same mutation, allowing those who are at risk to take proactive steps.In addition, the role of a proband goes beyond individual cases; it can also impact population-level studies. Epidemiologists may analyze data collected from multiple probands to identify trends and correlations across different demographics. This information can lead to improved public health policies and targeted interventions aimed at reducing the incidence of certain diseases.In conclusion, the term proband is integral to the fields of genetics and public health. By focusing on individuals who exhibit specific traits or conditions, researchers can unravel the complexities of heredity and disease. The insights gained from studying probands not only enhance our understanding of genetic disorders but also contribute to the development of personalized medicine and effective public health strategies. As science continues to evolve, the importance of probands in research and clinical practice will undoubtedly grow, paving the way for advancements in healthcare that benefit future generations.

在遗传学和流行病学领域，术语proband用于指代正在研究或评估的个体，特别是与特定遗传特征或疾病相关的个体。识别proband的重要性在于它能够提供有关遗传模式和某些疾病潜在风险因素的见解。理解proband的角色也可以帮助研究人员和医疗专业人员制定更有效的诊断和治疗策略。在进行家族研究时，研究人员通常首先识别一个proband。这个个体可能受到遗传疾病的影响，然后评估其家庭成员，以确定该病是否遗传。例如，如果一个孩子被诊断为罕见的遗传病，那么这个孩子就成为研究中的proband，父母和兄弟姐妹将被评估以查看他们是否携带相同的遗传标记。这种方法有助于理解疾病的遗传模式，并可以为受影响家庭制定更好的管理计划。proband的概念不仅对遗传研究至关重要，对公共卫生倡议也是如此。通过研究proband及其家庭，科学家可以识别可能促成某些疾病发展的环境或生活方式因素。例如，如果一个proband有心脏病史，研究人员可能会调查家庭中的饮食习惯、锻炼方式和其他生活选择，以确定促成疾病发作的因素。此外，识别proband可以帮助进行遗传咨询。遗传顾问利用从proband获得的信息来教育家庭关于遗传疾病的风险。他们可以提供筛查选项和预防措施的指导，这对于早期干预至关重要。例如，如果发现一个proband有与乳腺癌相关的突变，家庭成员可以接受相同突变的检测，从而使那些处于风险中的人采取积极措施。此外，proband的角色不仅限于个案研究；它还可以影响人口层面的研究。流行病学家可以分析来自多个proband的数据，以识别不同人群之间的趋势和关联。这些信息可以导致改善公共卫生政策和针对性的干预措施，旨在减少某些疾病的发生率。总之，术语proband在遗传学和公共卫生领域中至关重要。通过关注表现出特定特征或疾病的个体，研究人员可以揭示遗传和疾病的复杂性。从研究proband中获得的见解不仅增强了我们对遗传疾病的理解，还促进了个性化医学和有效公共卫生策略的发展。随着科学的不断发展，proband在研究和临床实践中的重要性无疑会增加，为未来几代人的医疗进步铺平道路。