allelic balance

简明释义

等位平衡;

英英释义

例句

1.The allelic balance 等位基因平衡 observed in this gene locus is critical for normal cell function.

在这个基因位点观察到的allelic balance 等位基因平衡对正常细胞功能至关重要。

2.Researchers need to assess the allelic balance 等位基因平衡 to understand the genetic diversity in crops.

研究人员需要评估allelic balance 等位基因平衡以了解作物的遗传多样性。

3.Monitoring the allelic balance 等位基因平衡 during breeding can enhance the success of genetic selection.

在育种过程中监测allelic balance 等位基因平衡可以提高遗传选择的成功率。

4.The study showed that the allelic balance 等位基因平衡 in the population was significantly disrupted by environmental factors.

研究表明，环境因素显著扰乱了人群中的allelic balance 等位基因平衡。

5.An imbalance in allelic balance 等位基因平衡 can lead to increased susceptibility to diseases.

在allelic balance 等位基因平衡中出现不平衡可能导致对疾病的易感性增加。

作文

In the field of genetics, understanding the concept of allelic balance is crucial for analyzing genetic variations and their implications on phenotypes. Allelic balance refers to the equal expression of two alleles at a given locus in a diploid organism. This means that both copies of a gene, inherited from each parent, contribute equally to the overall gene expression. When studying genetic traits, researchers often look for instances of allelic balance to determine how genes influence specific characteristics in an organism.The significance of allelic balance can be seen in various biological processes. For example, in the context of heterozygosity, where an individual carries two different alleles for a particular gene, maintaining allelic balance can lead to a more robust phenotype. This balance ensures that the advantageous traits associated with each allele are expressed, potentially enhancing the survival and adaptability of the organism. Conversely, when there is an imbalance, one allele may dominate, leading to a phenotype that does not fully utilize the genetic potential offered by both alleles.Research has shown that allelic balance is particularly important in cancer biology. Tumors often exhibit an altered allelic balance, which can influence their growth and response to treatments. For instance, if a tumor shows a predominance of one allele over another, it may result in the overexpression of oncogenes or the underexpression of tumor suppressor genes. Understanding the allelic balance in tumors can help in developing targeted therapies that aim to restore the natural balance of gene expression, potentially improving treatment outcomes.Moreover, the study of allelic balance extends beyond individual genes to encompass entire pathways and networks. Genetic interactions often rely on the balance between multiple alleles across various genes. Disruptions in this balance can lead to complex diseases, where multiple genetic factors contribute to the overall phenotype. By examining allelic balance within these networks, researchers can gain insights into the underlying mechanisms of diseases and identify potential therapeutic targets.In conclusion, allelic balance is a fundamental concept in genetics that plays a pivotal role in determining the expression of traits and the functioning of biological systems. Its implications are vast, spanning from basic genetic research to clinical applications in cancer therapy and disease management. As our understanding of allelic balance continues to evolve, it will undoubtedly enhance our ability to decipher the complexities of genetics and improve health outcomes for individuals affected by genetic disorders.

在遗传学领域，理解等位基因平衡的概念对于分析遗传变异及其对表型的影响至关重要。等位基因平衡指的是在二倍体生物中，某一特定基因位点上两个等位基因的表达相等。这意味着从每个父母那里遗传的基因副本都对整体基因表达做出同等贡献。在研究遗传特征时，研究人员通常会寻找等位基因平衡的实例，以确定基因如何影响生物体的特定特征。等位基因平衡的重要性可以在多种生物过程中特别明显。例如，在杂合性背景下，个体携带特定基因的两个不同等位基因，维持等位基因平衡可以导致更强健的表型。这种平衡确保了与每个等位基因相关的有利特征得以表达，从而可能增强生物体的生存能力和适应性。相反，当存在不平衡时，一个等位基因可能占主导地位，导致表型无法充分利用两个等位基因所提供的遗传潜力。研究表明，等位基因平衡在癌症生物学中尤其重要。肿瘤通常表现出改变的等位基因平衡，这可能影响其生长和治疗反应。例如，如果一个肿瘤显示出一个等位基因相对于另一个等位基因的优势，可能导致癌基因的过度表达或肿瘤抑制基因的不足表达。理解肿瘤中的等位基因平衡可以帮助开发针对性的治疗方法，旨在恢复基因表达的自然平衡，从而改善治疗效果。此外，等位基因平衡的研究不仅限于单个基因，还扩展到整个通路和网络。遗传相互作用往往依赖于跨多个基因的多个等位基因之间的平衡。这种平衡的破坏可能导致复杂疾病的发生，其中多个遗传因素共同影响整体表型。通过检查这些网络中的等位基因平衡，研究人员可以深入了解疾病的潜在机制，并识别潜在的治疗靶点。总之，等位基因平衡是遗传学中的一个基本概念，在决定特征的表达和生物系统的功能方面发挥着关键作用。它的影响范围广泛，从基础遗传研究到癌症治疗和疾病管理的临床应用。随着我们对等位基因平衡理解的不断深入，它无疑将增强我们解读遗传学复杂性的能力，并改善受遗传疾病影响个体的健康结果。