basement membrane

简明释义

基底膜

英英释义

例句

1.The integrity of the basement membrane is essential for maintaining tissue architecture.

保持组织结构完整性需要基底膜的健康。

2.In kidney function, the basement membrane plays a crucial role in filtering blood.

在肾脏功能中，基底膜在过滤血液中起着至关重要的作用。

3.Cancer cells can invade surrounding tissues by breaking down the basement membrane.

癌细胞可以通过破坏基底膜侵入周围组织。

4.During embryonic development, the formation of the basement membrane is critical for organogenesis.

在胚胎发育过程中，基底膜的形成对器官发生至关重要。

5.The structure of the skin is supported by the basement membrane, which acts as a barrier between the epidermis and dermis.

皮肤的结构由基底膜支持，作为表皮和真皮之间的屏障。

作文

The human body is a complex system made up of various types of cells and tissues that work together to maintain life. One critical component of this system is the basement membrane, which plays a vital role in supporting and anchoring epithelial tissues. The basement membrane is a thin, fibrous layer of extracellular matrix that separates epithelial cells from the underlying connective tissue. It provides structural support and acts as a barrier to regulate the movement of substances between the epithelium and the underlying tissues. Understanding the function of the basement membrane is essential for comprehending various physiological processes, including cell signaling, tissue repair, and immune responses. For instance, during wound healing, the basement membrane serves as a scaffold for new cells to migrate and proliferate, facilitating the restoration of the damaged tissue. Moreover, it plays a crucial role in maintaining the integrity of organs such as the kidneys, where the basement membrane is involved in filtration processes that prevent the loss of essential proteins from the bloodstream.In addition to its structural functions, the basement membrane also influences cellular behavior. It contains various proteins, such as collagen and laminin, that interact with cell surface receptors, triggering signaling pathways that regulate cell growth, differentiation, and survival. Disruptions in the composition or integrity of the basement membrane can lead to a range of diseases, including cancer, where tumor cells may invade surrounding tissues by degrading the basement membrane.Research has shown that the basement membrane is not merely a passive support structure but an active participant in cellular communication. For example, it can influence the migration of immune cells to sites of infection or injury, highlighting its role in the immune response. Furthermore, abnormalities in the basement membrane have been linked to various pathological conditions, including diabetes, where changes in the basement membrane can contribute to complications such as diabetic nephropathy.In conclusion, the basement membrane is a fundamental component of the body's architecture, providing support and regulation to epithelial tissues. Its multifaceted roles in cell signaling, tissue repair, and immune responses underscore its importance in maintaining health. Understanding the basement membrane and its functions can offer insights into the mechanisms of disease and potential therapeutic approaches for various medical conditions. As research continues to uncover the complexities of the basement membrane, it becomes increasingly clear that this seemingly simple structure is integral to the overall functioning of our bodies.

人体是一个复杂的系统，由各种类型的细胞和组织组成，这些细胞和组织共同合作以维持生命。其中一个关键组成部分是基底膜，它在支持和锚定上皮组织方面发挥着重要作用。基底膜是一个薄薄的、纤维状的细胞外基质层，分隔上皮细胞和下方的结缔组织。它提供结构支持，并作为屏障，调节物质在上皮和下层组织之间的移动。理解基底膜的功能对于理解各种生理过程至关重要，包括细胞信号传导、组织修复和免疫反应。例如，在创伤愈合过程中，基底膜作为新细胞迁移和增殖的支架，促进受损组织的恢复。此外，它在维持器官的完整性方面也起着至关重要的作用，例如在肾脏中，基底膜参与过滤过程，防止血液中重要蛋白质的流失。除了其结构功能外，基底膜还影响细胞行为。它包含多种蛋白质，如胶原蛋白和层粘连蛋白，这些蛋白质与细胞表面受体相互作用，触发调节细胞生长、分化和存活的信号通路。基底膜的组成或完整性的破坏可能导致一系列疾病，包括癌症，在癌细胞通过降解基底膜侵入周围组织时。研究表明，基底膜不仅仅是一个被动的支撑结构，而是细胞通信的积极参与者。例如，它可以影响免疫细胞向感染或损伤部位的迁移，突显其在免疫反应中的作用。此外，基底膜的异常已与各种病理状况相关联，包括糖尿病，其中基底膜的变化可能导致糖尿病肾病等并发症。总之，基底膜是身体结构的基本组成部分，为上皮组织提供支持和调节。它在细胞信号传导、组织修复和免疫反应中的多方面作用突显了其在维持健康中的重要性。理解基底膜及其功能可以为各种医学条件的疾病机制和潜在治疗方法提供见解。随着研究继续揭示基底膜的复杂性，越来越清楚的是，这个看似简单的结构对我们身体的整体功能至关重要。