adenylate cyclase

简明释义

腺苷酸环化酶

英英释义

例句

1.Research shows that certain drugs target adenylate cyclase to modulate heart function.

研究表明，某些药物针对腺苷酸环化酶以调节心脏功能。

2.The enzyme adenylate cyclase plays a crucial role in the signaling pathways of many hormones.

酶腺苷酸环化酶在许多激素的信号传导通路中起着至关重要的作用。

3.The activation of adenylate cyclase is a key step in the process of neurotransmission.

激活腺苷酸环化酶是神经传递过程中的关键步骤。

4.Mutations in genes coding for adenylate cyclase can result in various diseases.

编码腺苷酸环化酶的基因突变可能导致各种疾病。

5.Inhibition of adenylate cyclase can lead to decreased levels of cyclic AMP.

抑制腺苷酸环化酶会导致环磷酸腺苷水平下降。

作文

Adenylate cyclase is an important enzyme that plays a crucial role in cellular signaling. It catalyzes the conversion of ATP (adenosine triphosphate) to cAMP (cyclic adenosine monophosphate), which serves as a secondary messenger in various biological processes. Understanding the function of adenylate cyclase (腺苷酸酰化酶) is essential for comprehending how cells communicate and respond to external stimuli.In the realm of biochemistry, adenylate cyclase (腺苷酸酰化酶) is activated by various receptors on the cell surface, including G protein-coupled receptors (GPCRs). When a ligand binds to these receptors, it triggers a conformational change that activates the associated G proteins. The activated G proteins then stimulate adenylate cyclase (腺苷酸酰化酶), leading to an increase in the production of cAMP.cAMP is a vital molecule that regulates numerous physiological processes, including metabolism, gene expression, and cell division. For instance, in response to hormones like adrenaline, cAMP levels rise, which in turn activates protein kinase A (PKA). This activation leads to a cascade of events that ultimately result in increased heart rate and energy mobilization. Thus, adenylate cyclase (腺苷酸酰化酶) serves as a key player in the signaling pathways that govern such responses.Moreover, the activity of adenylate cyclase (腺苷酸酰化酶) can be modulated by various factors, including calcium ions and other signaling molecules. Certain drugs and toxins can also influence its activity, highlighting the enzyme's significance in pharmacology and therapeutics. For example, cholera toxin permanently activates adenylate cyclase (腺苷酸酰化酶), leading to an overproduction of cAMP and resulting in severe dehydration due to its effects on electrolyte transport in intestinal cells.Research into adenylate cyclase (腺苷酸酰化酶) has expanded our understanding of various diseases. Dysregulation of cAMP signaling is implicated in conditions such as heart failure, depression, and cancer. By targeting adenylate cyclase (腺苷酸酰化酶) or the pathways it influences, new therapeutic strategies are being developed to treat these ailments. In conclusion, adenylate cyclase (腺苷酸酰化酶) is a pivotal enzyme in the realm of cellular communication and signaling. Its ability to convert ATP to cAMP allows it to play a central role in many physiological processes. As research continues to uncover the complexities of this enzyme, it becomes increasingly clear that understanding adenylate cyclase (腺苷酸酰化酶) is fundamental to advancing our knowledge of biology and medicine.

腺苷酸酰化酶是一种重要的酶，在细胞信号传导中发挥着关键作用。它催化ATP（腺苷三磷酸）转化为cAMP（环腺苷单磷酸），后者作为多种生物过程中的次级信使。理解腺苷酸酰化酶（adenylate cyclase）的功能对于理解细胞如何与外部刺激进行沟通和反应至关重要。在生物化学领域，腺苷酸酰化酶（adenylate cyclase）通过细胞表面的各种受体被激活，包括G蛋白偶联受体（GPCR）。当配体与这些受体结合时，会触发构象变化，从而激活相关的G蛋白。激活的G蛋白随后刺激腺苷酸酰化酶（adenylate cyclase），导致cAMP的生成增加。cAMP是一个重要的分子，调节着许多生理过程，包括代谢、基因表达和细胞分裂。例如，在肾上腺素等激素的作用下，cAMP水平上升，这进一步激活蛋白激酶A（PKA）。这种激活导致一系列事件的级联反应，最终导致心率增加和能量动员。因此，腺苷酸酰化酶（adenylate cyclase）在调控此类反应的信号传导途径中扮演着关键角色。此外，腺苷酸酰化酶（adenylate cyclase）的活性可以受到多种因素的调节，包括钙离子和其他信号分子。某些药物和毒素也可以影响其活性，突显了该酶在药理学和治疗学中的重要性。例如，霍乱毒素永久激活腺苷酸酰化酶（adenylate cyclase），导致cAMP的过量产生，并因其对肠道细胞电解质转运的影响而导致严重脱水。对腺苷酸酰化酶（adenylate cyclase）的研究拓展了我们对多种疾病的理解。cAMP信号传导的失调与心力衰竭、抑郁症和癌症等疾病有关。通过针对腺苷酸酰化酶（adenylate cyclase）或其影响的途径，新的治疗策略正在开发，以治疗这些疾病。总之，腺苷酸酰化酶（adenylate cyclase）是细胞沟通和信号传导领域的关键酶。它将ATP转化为cAMP的能力使其在许多生理过程中发挥核心作用。随着研究不断揭示这一酶的复杂性，越来越清楚的是，理解腺苷酸酰化酶（adenylate cyclase）对于推动我们对生物学和医学的知识进步至关重要。