phenformin

简明释义

英[ˈfenfɔːmɪn]美[ˈfenfəmɪn]

n. 苯乙双胍；降糖灵（降血糖的药）

英英释义

单词用法

同义词

反义词

例句

1.Objective to develop a specific method for the identification of phenformin and glyburide illegally added into traditional Chinese medicine antidiabetic preparations and test some formulations.

目的建立检测中药降糖制剂中非法掺入的苯乙双胍和格列本脲专属性方法，并对若干市售药品进行检测。

2.Objective to develop a specific method for the identification of phenformin and glyburide illegally added into traditional Chinese medicine antidiabetic preparations and test some formulations.

目的建立检测中药降糖制剂中非法掺入的苯乙双胍和格列本脲专属性方法，并对若干市售药品进行检测。

3.Research has shown that phenformin can be effective in reducing blood sugar levels.

研究表明，苯福明在降低血糖水平方面可能有效。

4.The study focused on the long-term effects of phenformin on cardiovascular health.

该研究集中于苯福明对心血管健康的长期影响。

5.The doctor prescribed phenformin to help manage the patient's type 2 diabetes.

医生开了苯福明来帮助控制患者的2型糖尿病。

6.Due to its potential risks, phenformin is not commonly prescribed today.

由于其潜在风险，苯福明如今不常被开处方。

7.Patients taking phenformin should be monitored for any side effects.

服用苯福明的患者应监测任何副作用。

作文

The study of pharmaceuticals has always been a fascinating field, particularly when it comes to understanding the mechanisms and effects of various drugs. One such drug that has garnered attention in recent years is phenformin, a medication that was historically used to treat type 2 diabetes. Although it has been largely replaced by other medications due to safety concerns, its history and the science behind it provide valuable insights into diabetes management and drug development. Phenformin is an oral hypoglycemic agent that belongs to the biguanide class of drugs. It works primarily by decreasing hepatic glucose production and improving insulin sensitivity. This mechanism makes it effective in lowering blood sugar levels in diabetic patients. However, despite its effectiveness, phenformin was withdrawn from the market in many countries due to its association with lactic acidosis, a rare but serious side effect that can occur when lactic acid builds up in the bloodstream. The withdrawal of phenformin highlights the importance of balancing efficacy with safety in drug development. While it was beneficial for many patients, the risks associated with its use prompted researchers and healthcare providers to seek safer alternatives. As a result, metformin, another biguanide, became the preferred choice for managing type 2 diabetes. Metformin shares some similarities with phenformin in terms of its mechanism of action but has a much better safety profile. This transition from phenformin to metformin serves as a crucial lesson in the pharmaceutical industry. It underscores the need for rigorous clinical trials and post-marketing surveillance to ensure that medications are not only effective but also safe for long-term use. Furthermore, the story of phenformin illustrates the dynamic nature of medical research. As our understanding of diseases and drug interactions evolves, so too does the landscape of available treatments. Newer therapies are constantly being developed and tested, which may one day lead to the re-evaluation of older drugs like phenformin. In recent years, there has been renewed interest in the potential benefits of biguanides, spurring research into their mechanisms and possible applications beyond diabetes treatment. Researchers are investigating whether phenformin or similar compounds could have roles in cancer treatment or metabolic disorders, given their effects on cellular metabolism. This ongoing exploration reflects the broader trend in medicine of repurposing existing drugs for new therapeutic uses. In conclusion, while phenformin may no longer be a staple in diabetes management, its legacy continues to influence the field of pharmacology. The lessons learned from its use and subsequent withdrawal emphasize the importance of patient safety and the need for continuous research in drug development. As we advance our understanding of diabetes and related conditions, phenformin serves as a reminder of both the potential and the pitfalls of pharmaceutical innovation. The future may hold new discoveries that could reintegrate phenformin or its derivatives into clinical practice, demonstrating that even drugs once considered obsolete can find new life in the ever-evolving world of medicine.

药物学的研究一直是一个引人入胜的领域，尤其是在理解各种药物的机制和效果方面。近年来，一种引起关注的药物是苯乙胺，这是一种历史上用于治疗2型糖尿病的药物。尽管由于安全性问题，它在许多国家已被其他药物所取代，但它的历史和背后的科学为糖尿病管理和药物开发提供了宝贵的见解。苯乙胺是一种口服降糖药，属于双胍类药物。它主要通过减少肝脏葡萄糖产生和改善胰岛素敏感性来发挥作用。这种机制使其在降低糖尿病患者的血糖水平方面有效。然而，尽管其有效性，苯乙胺因与乳酸中毒相关而在许多国家被撤回，这是一种罕见但严重的副作用，可能发生在乳酸在血液中积聚时。苯乙胺的撤回突显了在药物开发中平衡疗效与安全性的重要性。虽然它对许多患者有益，但其使用相关的风险促使研究人员和医疗提供者寻求更安全的替代方案。因此，二甲双胍，另一种双胍类药物，成为管理2型糖尿病的首选。二甲双胍在作用机制上与苯乙胺有一些相似之处，但具有更好的安全性。这种从苯乙胺到二甲双胍的过渡为制药行业提供了一个重要的教训。它强调了进行严格的临床试验和上市后监测的必要性，以确保药物不仅有效，而且在长期使用中也安全。此外，苯乙胺的故事说明了医学研究的动态性质。随着我们对疾病和药物相互作用的理解不断发展，可用治疗方法的格局也在不断变化。新的治疗方法不断被开发和测试，这可能会导致对像苯乙胺这样的旧药物进行重新评估。近年来，人们对双胍类药物潜在益处的兴趣重新燃起，促使研究人员探讨它们的机制和可能在糖尿病治疗之外的应用。研究人员正在调查苯乙胺或类似化合物在癌症治疗或代谢紊乱中的作用，因为它们对细胞代谢的影响。这种持续的探索反映了医学中将现有药物重新利用于新治疗用途的更广泛趋势。总之，虽然苯乙胺可能不再是糖尿病管理的主流，但它的遗产继续影响药理学领域。从其使用和随后的撤回中获得的教训强调了患者安全的重要性以及药物开发中持续研究的必要性。随着我们对糖尿病及相关疾病的理解不断加深，苯乙胺提醒我们药物创新的潜力与陷阱。未来可能会出现新的发现，使苯乙胺或其衍生物重新融入临床实践，证明即便是曾被视为过时的药物也能在医学日益发展的世界中焕发新生。