replicase

简明释义

英[ˈreplɪˌkeɪs]美[ˈreplɪˌkeɪs]

n. [生化] 复制酶

英英释义

单词用法

同义词

反义词

例句

1.It was a kind of promising method to use viral replicase gene in anti-virus plant genetic engineering.

在抗病毒植物基因工程中，利用病毒的复制酶基因是一种很有前途的方法。

2.It was a kind of promising method to use viral replicase gene in anti-virus plant genetic engineering.

在抗病毒植物基因工程中，利用病毒的复制酶基因是一种很有前途的方法。

3.The enzyme known as replicase is crucial for the replication of RNA viruses.

被称为复制酶的酶对于RNA病毒的复制至关重要。

4.Understanding the mechanism of replicase can lead to new vaccine developments.

理解复制酶的机制可以促进新疫苗的开发。

5.In the laboratory, scientists isolated the replicase from a sample of the virus.

在实验室中，科学家从病毒样本中分离出了复制酶。

6.The activity of replicase can be inhibited by certain antiviral compounds.

某些抗病毒化合物可以抑制复制酶的活性。

7.Researchers are studying how replicase functions to improve antiviral therapies.

研究人员正在研究复制酶的功能，以改善抗病毒疗法。

作文

In the world of molecular biology, enzymes play crucial roles in various biological processes. One such enzyme is replicase, which is essential for the replication of RNA viruses. Understanding the function and importance of replicase can provide insights into viral replication mechanisms and potential therapeutic targets for antiviral drugs.Replicase is a type of RNA-dependent RNA polymerase that synthesizes RNA from an RNA template. This process is vital for the life cycle of RNA viruses, as it allows them to replicate their genetic material within host cells. Unlike DNA viruses, which utilize host cell machinery to replicate their DNA, RNA viruses rely on replicase to produce new RNA strands that can be translated into viral proteins or packaged into new virions.The mechanism by which replicase operates involves several steps. First, the enzyme binds to the viral RNA genome, which serves as a template. Once bound, replicase unwinds the RNA structure and begins synthesizing a complementary RNA strand by adding nucleotides that are complementary to the template. This process continues until a full-length RNA molecule is synthesized, which can then serve either as a messenger RNA (mRNA) for protein synthesis or as a new genomic RNA for packaging into new virus particles.The study of replicase has significant implications for understanding viral pathogenesis and developing antiviral strategies. For instance, researchers have identified that inhibiting replicase activity can effectively reduce viral replication, making it a promising target for drug development. Several antiviral agents are designed to specifically inhibit replicase, thereby preventing the virus from proliferating within the host.Moreover, the evolution of replicase among different RNA viruses highlights the adaptability of these pathogens. Variations in the replicase enzyme can lead to differences in replication efficiency, mutation rates, and ultimately, the virulence of the virus. This adaptability poses challenges for vaccine development, as changes in replicase can result in the emergence of resistant viral strains.In conclusion, replicase is a vital enzyme in the life cycle of RNA viruses, facilitating the replication of their genetic material within host cells. Understanding its function not only sheds light on viral biology but also opens pathways for the development of targeted antiviral therapies. As research continues to unveil the complexities of replicase and its role in viral replication, we move closer to finding effective solutions to combat RNA virus infections, which remain a significant global health challenge.

在分子生物学的世界中，酶在各种生物过程中发挥着至关重要的作用。其中一种酶是replicase，它对RNA病毒的复制至关重要。理解replicase的功能和重要性可以为我们提供对病毒复制机制和潜在抗病毒药物治疗靶点的深入了解。Replicase是一种RNA依赖的RNA聚合酶，它从RNA模板合成RNA。这一过程对于RNA病毒的生命周期至关重要，因为它使得病毒能够在宿主细胞内复制其遗传物质。与利用宿主细胞机制复制其DNA的DNA病毒不同，RNA病毒依赖于replicase来产生新的RNA链，这些链可以翻译成病毒蛋白或包装成新的病毒颗粒。Replicase的操作机制涉及几个步骤。首先，酶与病毒RNA基因组结合，后者作为模板。一旦结合，replicase就会解开RNA结构，并开始通过添加与模板互补的核苷酸来合成互补的RNA链。这个过程将持续，直到合成出完整的RNA分子，该分子可以作为信使RNA（mRNA）用于蛋白质合成，或者作为新的基因组RNA用于包装成新的病毒颗粒。对replicase的研究具有重要的意义，因为它有助于理解病毒致病机制以及开发抗病毒策略。例如，研究人员发现抑制replicase活性可以有效减少病毒复制，使其成为药物开发的一个有前景的靶点。几种抗病毒剂被设计为专门抑制replicase，从而阻止病毒在宿主内增殖。此外，replicase在不同RNA病毒之间的进化突显了这些病原体的适应性。Replicase酶的变异可能导致复制效率、突变率以及最终病毒毒力的差异。这种适应性给疫苗开发带来了挑战，因为replicase中的变化可能导致耐药病毒株的出现。总之，replicase是RNA病毒生命周期中的一种重要酶，促进其遗传物质在宿主细胞内的复制。理解其功能不仅揭示了病毒生物学，还为开发针对性的抗病毒疗法开辟了道路。随着研究不断揭示replicase及其在病毒复制中角色的复杂性，我们离找到有效解决方案以对抗RNA病毒感染的目标又近了一步，而RNA病毒感染仍然是全球健康面临的重要挑战。