lysosomal

简明释义

英[ˌlaɪsəˈsoʊməl]美[ˌlaɪsəˈsoʊməl]

溶酶体的

英英释义

单词用法

同义词

反义词

例句

1.It suggests that ACP (with other lysosomal enzymes) may play an important role in the retinal damage after acute ocular hypertension.

提示ACP(及其他溶酶体酶)可能在急性高眼压后的视网膜损伤过程中起重要作用。

2.Objective: to isolate copper binding protein from rat liver lysosomal fraction, and to analyze its amino acid sequences.

目的：分离大鼠肝脏溶酶体中铜结合蛋白质，并分析其氨基酸序列。

3.Some extracellular proenzymes may be activated by secreted lysosomal proteinases.

有些细胞外酶原能被分泌的溶酶体蛋白酶所激活。

4.Vesicles cannot be formed in the absence of newly-synthesized lysosomal proteins.

如果没有新合成的溶酶体蛋白质，就没有溶酶体囊泡形成。

5.Aim to explore the effect of oxidized low density lipoprotein (ox LDL) on cholesterol accumulation in mouse peritoneal macrophages and its relationship with activity of lysosomal cathepsin.

研究氧化型低密度脂蛋白对小鼠腹腔巨噬细胞胆固醇蓄积的影响，并探讨其与组织蛋白酶活性之间的关系。

6.One of the mechanisms of anti-inflammatory actions of musk is through inhibition of lysosomal enzyme release.

抑制溶酶体酶释放可能是麝香抗炎作用机制之一。

7.Non-lysosomal acid phosphatase was observed between the spore coat and spore membrane.

在孢子细胞外被与质膜间也观察到非溶酶体酸性磷酸酶。

8.In vitro experiments showed that anisodamine had no direct stabilizing effect on isolated hepatic lysosomal granules from shocked rats, which effect is different from that of steroid.

在体外实验中，山茛菪碱对分离出的休克大鼠肝溶酶体无直接作用，提示654 - 2在整体实验中显示出的保护肝脏溶酶体作用的机理与地塞米松不同。

9.Estimation of lymphocyte acid phosphatase (ACP) activity was adopted as the marker of the change of lysosomal membrane permeability.

用外周血淋巴细胞ACP活力检测作为淋巴细胞溶酶体膜通透性改变的标志。

10.Certain drugs can enhance lysosomal activity to improve cellular health.

某些药物可以增强溶酶体活性，以改善细胞健康。

11.The lysosomal enzyme plays a crucial role in breaking down waste materials within the cell.

这个溶酶体的酶在细胞内分解废物材料中扮演着重要角色。

12.The accumulation of undigested material in the lysosomal system can be harmful to cells.

未消化物质在溶酶体系统中的积累对细胞是有害的。

13.Researchers are studying lysosomal storage diseases to develop better treatments.

研究人员正在研究溶酶体储存疾病，以开发更好的治疗方法。

14.Defects in lysosomal function can lead to various genetic disorders.

在溶酶体功能上的缺陷可能导致各种遗传疾病。

作文

The human body is a complex system, composed of various types of cells that perform specific functions essential for life. One of the critical components of these cells is the organelle known as the lysosome. The term lysosomal refers to anything related to these organelles, which play a vital role in cellular digestion and waste management. Lysosomes are often termed the 'recycling centers' of the cell because they contain enzymes that break down macromolecules, old cell parts, and microorganisms. Understanding the function of lysosomal systems is crucial in the study of cellular biology and medicine.Lysosomes are membrane-bound organelles that contain hydrolytic enzymes capable of breaking down different types of biomolecules, including proteins, lipids, carbohydrates, and nucleic acids. The enzymes within lysosomes are active at an acidic pH, which is maintained by proton pumps in the lysosomal membrane. This unique environment allows for the efficient degradation of materials that the cell no longer needs or that could be harmful if left unchecked. The lysosomal pathway is essential for cellular homeostasis and plays a significant role in autophagy, a process where cells degrade and recycle their own components.In recent years, research has increasingly focused on the implications of lysosomal function in various diseases. For instance, lysosomal storage disorders are a group of inherited metabolic conditions that arise from the dysfunction of lysosomal enzymes. These disorders can lead to the accumulation of undigested substrates within the lysosomes, causing cellular dysfunction and a range of symptoms. Examples include Tay-Sachs disease and Gaucher's disease, both of which are linked to specific enzyme deficiencies within the lysosomal system.Moreover, the role of lysosomes extends beyond mere waste disposal. They are involved in signaling pathways that regulate cell metabolism, immune responses, and even apoptosis, or programmed cell death. The interaction between lysosomes and other organelles, such as mitochondria, highlights their importance in maintaining cellular health. Dysregulation of lysosomal function has been implicated in various conditions, including neurodegenerative diseases like Alzheimer's and Parkinson's, where the clearance of damaged proteins becomes impaired.Research into lysosomal biology is also paving the way for novel therapeutic strategies. Enzyme replacement therapy is one approach being explored for treating lysosomal storage disorders, where patients receive the missing or deficient enzyme to help restore normal function. Additionally, drugs that enhance lysosomal function are being investigated for their potential to treat neurodegenerative diseases by improving the clearance of toxic aggregates.In conclusion, the lysosomal system is fundamental to the health and functioning of cells. Its role in digestion, recycling, and cellular signaling underscores its importance in both normal physiology and disease states. As our understanding of lysosomal biology continues to grow, it opens new avenues for research and potential treatments for a variety of conditions. The future of medicine may very well hinge on our ability to manipulate these tiny yet powerful organelles to promote health and combat disease.

人体是一个复杂的系统，由多种类型的细胞组成，这些细胞执行对生命至关重要的特定功能。其中一个关键组成部分是被称为溶酶体的细胞器。术语lysosomal指的是与这些细胞器相关的任何事物，它们在细胞消化和废物管理中发挥着重要作用。溶酶体通常被称为细胞的“回收中心”，因为它们含有分解大分子、旧细胞部分和微生物的酶。理解lysosomal系统的功能对于细胞生物学和医学的研究至关重要。溶酶体是膜结合的细胞器，含有水解酶，能够分解不同类型的生物分子，包括蛋白质、脂质、碳水化合物和核酸。溶酶体内的酶在酸性pH值下活跃，这种环境是通过溶酶体膜中的质子泵维持的。这种独特的环境使得细胞不再需要或可能有害的物质能够有效降解。lysosomal途径对于细胞稳态至关重要，并在自噬过程中发挥重要作用，自噬是细胞降解和回收自身成分的过程。近年来，研究越来越关注lysosomal功能在各种疾病中的影响。例如，溶酶体贮积病是一组遗传代谢疾病，源于溶酶体酶的功能障碍。这些疾病可能导致未消化底物在溶酶体内的积累，导致细胞功能障碍和一系列症状。例子包括泰-萨克斯病和高雪伯病，这两者都与lysosomal系统内特定酶缺陷有关。此外，溶酶体的作用不仅限于废物处理。它们参与调节细胞代谢、免疫反应甚至凋亡（或程序性细胞死亡）的信号通路。溶酶体与其他细胞器（如线粒体）之间的相互作用突显了它们在维持细胞健康方面的重要性。lysosomal功能的失调与各种疾病有关，包括阿尔茨海默病和帕金森病等神经退行性疾病，其中损伤蛋白的清除受到阻碍。对lysosomal生物学的研究也为新型治疗策略铺平了道路。酶替代疗法是一种正在探索的方法，用于治疗溶酶体贮积病，患者接受缺失或缺乏的酶，以帮助恢复正常功能。此外，增强溶酶体功能的药物也在研究中，作为改善神经退行性疾病中毒性聚集物清除的潜力。总之，lysosomal系统是细胞健康和功能的基础。它在消化、回收和细胞信号传导中的作用突显了它在正常生理和疾病状态中的重要性。随着我们对lysosomal生物学理解的不断深入，它为各种疾病的研究和潜在治疗开辟了新的途径。未来医学的发展很可能依赖于我们操控这些微小而强大的细胞器以促进健康和抗击疾病的能力。